Search Results - "Sobti, Meghna"

The six steps of the complete F1-ATPase rotary catalytic cycle by Sobti, Meghna, Ueno, Hiroshi, Noji, Hiroyuki, Stewart, Alastair G.

“…F 1 F o ATP synthase interchanges phosphate transfer energy and proton motive force via a rotary catalysis mechanism. Isolated F 1 -ATPase catalytic cores can…”
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Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch by Sobti, Meghna, Walshe, James L., Wu, Di, Ishmukhametov, Robert, Zeng, Yi C., Robinson, Carol V., Berry, Richard M., Stewart, Alastair G.

“…F 1 F o ATP synthase functions as a biological rotary generator that makes a major contribution to cellular energy production. It comprises two molecular…”
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Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states by Sobti, Meghna, Smits, Callum, Wong, Andrew Sw, Ishmukhametov, Robert, Stock, Daniela, Sandin, Sara, Stewart, Alastair G

“…A molecular model that provides a framework for interpreting the wealth of functional information obtained on the F-ATP synthase has been generated using…”
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Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP by Sobti, Meghna, Ishmukhametov, Robert, Bouwer, James C, Ayer, Anita, Suarna, Cacang, Smith, Nicola J, Christie, Mary, Stocker, Roland, Duncan, Thomas M, Stewart, Alastair G

“…ATP synthase produces the majority of cellular energy in most cells. We have previously reported cryo-EM maps of autoinhibited ATP synthase imaged without…”
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ATP Synthase: Expression, Purification, and Function by Sobti, Meghna, Ishmukhametov, Robert, Stewart, Alastair G

“…ATP synthase is an essential enzyme found in all known forms of life, generating the majority of cellular energy via a rotary catalytic mechanism. Here, we…”
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies by Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

“…Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant…”
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Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP by Sobti, Meghna, Zeng, Yi C., Walshe, James L., Brown, Simon H. J., Ishmukhametov, Robert, Stewart, Alastair G.

“…F 1 F o ATP synthase functions as a biological generator and makes a major contribution to cellular energy production. Proton flow generates rotation in the F…”
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Molecular basis for GIGYF-TNRC6 complex assembly by Sobti, Meghna, Mead, Benjamin J, Stewart, Alastair G, Igreja, Cátia, Christie, Mary

“…The GIGYF proteins interact with 4EHP and RNA-associated proteins to elicit transcript-specific translational repression. However, the mechanism by which the…”
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Rotary ATPases—dynamic molecular machines by Stewart, Alastair G, Laming, Elise M, Sobti, Meghna, Stock, Daniela

“…•Visualization of rotary ATPases on nanometre scale by cryo-electron microscopy.•In situ visualization of mitochondrial ATP synthase by electron…”
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Glutamate transporters have a chloride channel with two hydrophobic gates by Chen, Ichia, Pant, Shashank, Wu, Qianyi, Cater, Rosemary J., Sobti, Meghna, Vandenberg, Robert J., Stewart, Alastair G., Tajkhorshid, Emad, Font, Josep, Ryan, Renae M.

“…Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function…”
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The molecular structure of an axle-less F1-ATPase by Furlong, Emily J., Reininger-Chatzigiannakis, Ian-Blaine P., Zeng, Yi C., Brown, Simon H.J., Sobti, Meghna, Stewart, Alastair G.

“…F1Fo ATP synthase is a molecular rotary motor that can generate ATP using a transmembrane proton motive force. Isolated F1-ATPase catalytic cores can hydrolyse…”
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A Novel Chloride Conducting Conformation in Human Glutamate Transporters by Pant, Shashank, Chen, Ichia, Wu, Qianyi, Cater, Rosemary, Sobti, Meghna, Vandenberg, Robert J., Stewart, Alastair G., Font, Josep, Ryan, Renae M., Tajkhorshid, Emad

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Glutamate Transporters (EAATS) Contain a Conserved Chloride Channel with Two Hydrophobic Gates by Chen, Ichia, Pant, Shashank, Wu, Qianyi, Cater, Rosemary J., Sobti, Meghna, Vandenberg, Robert J., Stewart, Alastair, Font, Josep, Tajkhorshid, Emad, Ryan, Renae M.

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The molecular structure of an axle-less F 1 -ATPase by Furlong, Emily J, Reininger-Chatzigiannakis, Ian-Blaine P, Zeng, Yi C, Brown, Simon H J, Sobti, Meghna, Stewart, Alastair G

“…F F ATP synthase is a molecular rotary motor that can generate ATP using a transmembrane proton motive force. Isolated F -ATPase catalytic cores can hydrolyse…”
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Structural analysis of the Sulfolobus solfataricus TF55β chaperonin by cryo‐electron microscopy by Zeng, Yi Cheng, Sobti, Meghna, Stewart, Alastair G.

“…Chaperonins are biomolecular complexes that assist in protein folding. Thermophilic factor 55 (TF55) is a group II chaperonin found in the archaeal genus…”
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Changes within the central stalk of E. coli F 1 F o ATP synthase observed after addition of ATP by Sobti, Meghna, Zeng, Yi C, Walshe, James L, Brown, Simon H J, Ishmukhametov, Robert, Stewart, Alastair G

“…F F ATP synthase functions as a biological generator and makes a major contribution to cellular energy production. Proton flow generates rotation in the F…”
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Rotary ATPases: models, machine elements and technical specifications by Stewart, Alastair G, Sobti, Meghna, Harvey, Richard P, Stock, Daniela

“…Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy…”
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Cryo-EM structures provide insight into how E. coli F 1 F o ATP synthase accommodates symmetry mismatch by Sobti, Meghna, Walshe, James L, Wu, Di, Ishmukhametov, Robert, Zeng, Yi C, Robinson, Carol V, Berry, Richard M, Stewart, Alastair G

“…F F ATP synthase functions as a biological rotary generator that makes a major contribution to cellular energy production. It comprises two molecular motors…”
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