Search Results - "Sobotka, J."

Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval by Eichler, H‐G, Oye, K, Baird, L G, Abadie, E, Brown, J, Drum, C L, Ferguson, J, Garner, S, Honig, P, Hukkelhoven, M, Lim, J C W, Lim, R, Lumpkin, M M, Neil, G, O'Rourke, B, Pezalla, E, Shoda, D, Seyfert‐Margolis, V, Sigal, E V, Sobotka, J, Tan, D, Unger, T F, Hirsch, G

“…Traditional drug licensing approaches are based on binary decisions. At the moment of licensing, an experimental therapy is presumptively transformed into a…”
Get full text

Normal and shear behaviours of the auxetic metamaterials: homogenisation and experimental approaches by Henyš, P., Vomáčko, V., Ackermann, M., Sobotka, J., Solfronk, P., Šafka, J., Čapek, L.

“…The auxetic metamaterials exhibit attractive mechanical properties, including negative Poisson’s ratio and compressional resistance. Although auxetic…”
Get full text

Validation of breast implant finite element model by Kovar, M., Flynn, C., Sobotka, J., Capek, L.

Get full text

Effects of steady ductile crack growth on cleavage fracture from three-dimensional, small-scale yielding simulations by Sobotka, J.C., Dodds, R.H.

“…•3D steady growth in plastically deforming material under SSY conditions.•Weibull stress describes increased probability of cleavage fracture.•Plane-sided and…”
Get full text

T-stress effects on steady crack growth in a thin, ductile plate under small-scale yielding conditions: Three-dimensional modeling by Sobotka, J.C., Dodds, R.H.

“…The non-singular T-stress provides a first-order estimate of geometry and loading mode, e.g. tension vs. bending, effects on elastic–plastic, crack-front…”
Get full text

Side-groove effects in three-dimensional small-scale yielding: A load and thickness-scaling model by Sobotka, J.C., Dodds, R.H.

“…► Employs extraordinarily refined 3D models to compute high-fidelity deformations in the crack-front region. ► Reveals an improved, quantitative understanding…”
Get full text

Steady crack growth in a thin, ductile plate under small-scale yielding conditions: Three-dimensional modeling by Sobotka, J.C., Dodds, R.H.

“…This work employs high resolution, finite element computations to investigate key features of the elastic–plastic fields near a steadily advancing crack at…”
Get full text

Dynamic and static characterization of compact crack arrest tests of navy and nuclear steels by Joyce, James A., Link, R.E., Roe, C., Sobotka, J.C.

“…Recent experimental and computational work by Link and associates has demonstrated that relatively small ( W = 150 mm) single edge notched tension specimens…”
Get full text

Effects of hydrogen on steady, ductile crack growth: Computational studies by Sobotka, J.C., Dodds, R.H., Sofronis, P.

“…This paper describes studies of the near tip fields and the effects on void growth rates for a steadily advancing crack through a ductile metal in the presence…”
Get full text

Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide by Wiesenfeld, Paddy L., Garthoff, Larry H., Sobotka, Thomas J., Suagee, Jessica K., Barton, Curtis N.

“…The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg−1 body weight) of colchicine (COL) was determined in young, mature male and female…”
Get full text

Neurobehavioral dysfunctions associated with dietary iron overload by Sobotka, T.J., Whittaker, P., Sobotka, J.M., Brodie, R.E., Wander, D.Y., Robl, M., Bryant, M., Barton, C.N.

“…Excessive dietary Fe is known to be toxic, but the extent of neurobiological involvement is not clear. In the present study male weanling rats were fed diets…”
Get full text

Transcending Tinkering: Building Understanding of Content and the Nature of the STEM Disciplines by Sobotka, Alex J., Clough, Michael P.

“…Design activities can serve as a concrete experience to address the similarities and differences between science and engineering, and also demarcate…”
Get full text

Plotting Success: A Communication Activity for Promoting Graph Literacy by Sobotka, Alex J., Janney, Benjamin A., Kidd, Aaron E.

“…Graphical representations appear everywhere in modern society. Their ubiquity has, in part, justified graph literacy as a core competency in education. Graph…”
Get full text

A Comparison of Metabolic Rates in Off‐Channel Habitats of the Middle Mississippi River by Sobotka, M. J., Phelps, Q. E.

“…Autochthonous material has been found to be an important base in large river food webs. However, a spatial understanding of primary production in large rivers…”
Get full text

A Comparison of Main and Side Channel Physical and Water Quality Metrics and Habitat Complexity in the Middle Mississippi River by Sobotka, M. J., Phelps, Q. E.

“…Worldwide large rivers have been severely modified by human intervention. Many modifications result in disconnection of the river from floodplain and…”
Get full text

Persistent Neonatal Borna Disease Virus (BDV) Infection of the Brain Causes Chronic Emotional Abnormalities in Adult Rats by Pletnikov, Mikhail V, Rubin, Steven A, Schwartz, Gary J, Moran, Timothy H, Sobotka, Thomas J, Carbone, Kathryn M

“…Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature,…”
Get full text

Identification and interpretation of developmental neurotoxicity effects by Tyl, Rochelle W, Crofton, Kevin, Moretto, Angelo, Moser, Virginia, Sheets, Larry P, Sobotka, Thomas J

“…Abstract The reliable detection, measurement, and interpretation of treatment-related developmental neurotoxicity (DNT) effects depend on appropriate study…”
Get full text

Decontextualizing Velocity and Acceleration in a Concrete (and Sweet) Eating Activity by Janney, Benjamin A., Sobotka, Alex J., Kidd, Aaron E.

“…Despite holding wide-ranging experiences with constant velocity and non-zero acceleration, students wrestling with physical science concepts struggle to…”
Get full text

Stress-intensity factors solutions for straight through cracks in C-sections by Sobotka, J.C., McClung, R.C.

“…This work details a new stress-intensity factor (SIF) solution for a through-thickness edge crack in a structural member with a cross-section idealized as a…”
Get full text

Fish Associations among Un-notched, Notched and L-head Dikes in the Middle Mississippi River by Braun, Andrew P., Sobotka, Molly J., Phelps, Quinton E.

“…Wing dikes and other anthropogenic modifications have heavily altered riverine ecosystems. Recent efforts to reach a compromise between the needs of the river…”
Get full text