Search Results - "Sobotka, A"

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study by Krum, Henry, Prof, Schlaich, Markus, MD, Whitbourn, Rob, MBBS, Sobotka, Paul A, MD, Sadowski, Jerzy, Prof, Bartus, Krzysztof, MD, Kapelak, Boguslaw, MD, Walton, Anthony, MBBS, Sievert, Horst, Prof, Thambar, Suku, MBBS, Abraham, William T, Prof, Esler, Murray, Prof

“…Summary Background Renal sympathetic hyperactivity is associated with hypertension and its progression, chronic kidney disease, and heart failure. We did a…”
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Predictors of blood pressure response in the SYMPLICITY HTN-3 trial by Kandzari, David E, Bhatt, Deepak L, Brar, Sandeep, Devireddy, Chandan M, Esler, Murray, Fahy, Martin, Flack, John M, Katzen, Barry T, Lea, Janice, Lee, David P, Leon, Martin B, Ma, Adrian, Massaro, Joseph, Mauri, Laura, Oparil, Suzanne, O'Neill, William W, Patel, Manesh R, Rocha-Singh, Krishna, Sobotka, Paul A, Svetkey, Laura, Townsend, Raymond R, Bakris, George L

“…The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed the safety of renal denervation (RDN), but did not meet its primary efficacy…”
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Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension by Sobotka, Paul A, Lambert, Elisabeth, Krum, Henry, Schlaich, Markus P, Esler, Murray D

“…To the Editor: The renal sympathetic nerves have been identified as a major contributor to the complex pathophysiology of hypertension in both experimental…”
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Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study by Krum, Henry, Prof, Schlaich, Markus P, Prof, Sobotka, Paul A, Prof, Böhm, Michael, MD, Mahfoud, Felix, MD, Rocha-Singh, Krishna, MD, Katholi, Richard, MD, Esler, Murray D, Prof

“…Summary Background Renal denervation (RDN) with radiofrequency ablation substantially reduces blood pressure in patients with treatment-resistant hypertension…”
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The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension by McBryde, Fiona D., Abdala, Ana P., Hendy, Emma B., Pijacka, Wioletta, Marvar, Paul, Moraes, Davi J. A., Sobotka, Paul A., Paton, Julian F. R.

“…In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and…”
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First-in-man safety evaluation of renal denervation for chronic systolic heart failure: Primary outcome from REACH-Pilot study by Davies, Justin E, Manisty, Charlotte H, Petraco, Ricardo, Barron, Anthony J, Unsworth, Beth, Mayet, Jamil, Hamady, Mohamad, Hughes, Alun D, Sever, Peter S, Sobotka, Paul A, Francis, Darrel P

“…Abstract Background Sympathetic overactivation, is reduced by renal denervation in drug-resistant hypertension. A similar role for renal denervation in heart…”
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Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat by Abdala, Ana P., McBryde, Fiona D., Marina, Nephtali, Hendy, Emma B., Engelman, Zoar J., Fudim, Marat, Sobotka, Paul A., Gourine, Alexander V., Paton, Julian F. R.

“…Key points Peripheral chemoreflex sensitivity is enhanced in hypertension yet the role of these receptors in the development and maintenance of high blood…”
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Carotid body resection for sympathetic modulation in systolic heart failure: results from first‐in‐man study by Niewinski, Piotr, Janczak, Dariusz, Rucinski, Artur, Tubek, Stanislaw, Engelman, Zoar J., Piesiak, Pawel, Jazwiec, Przemyslaw, Banasiak, Waldemar, Fudim, Marat, Sobotka, Paul A., Javaheri, Shahrokh, Hart, Emma C.J., Paton, Julian F.R., Ponikowski, Piotr

“…Aims Augmented reflex responses from peripheral chemoreceptors, which are mainly localized in the carotid bodies (CBs), characterize patients with systolic…”
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THE DISSIMILAR CHEMICAL COMPOSITION OF THE PLANET-HOSTING STARS OF THE XO-2 BINARY SYSTEM by Ramírez, I., Khanal, S., Aleo, P., Sobotka, A., Liu, F., Casagrande, L., Meléndez, J., Yong, D., Lambert, D. L., Asplund, M.

“…ABSTRACT Using high-quality spectra of the twin stars in the XO-2 binary system, we have detected significant differences in the chemical composition of their…”
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The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases by Paton, Julian F.R, Sobotka, Paul A, Fudim, Marat, Engleman, Zoar J, Hart, Emma C.J, McBryde, Fiona D, Abdala, Ana P, Marina, Nepthali, Gourine, Alexander V, Lobo, Mel, Patel, Nik, Burchell, Amy, Ratcliffe, Laura, Nightingale, Angus

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PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral Dynamics by Sobotka, Asher A, Tempera, Italo

“…The principal understanding of the Poly(ADP-ribose) polymerase (PARP) regulation of genomes has been focused on its role in DNA repair; however, in the past…”
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Blood Pressure Variability in Clinical Practice: Past, Present and the Future by Sheikh, Abu Baker, Sobotka, Paul A, Garg, Ishan, Dunn, Jessilyn P, Minhas, Abdul Mannan Khan, Shandhi, Md Mobashir Hasan, Molinger, Jeroen, McDonnell, Barry J, Fudim, Marat

“…Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart…”
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Catheter‐Based Renal Denervation for Resistant Hypertension: Rationale and Design of the SYMPLICITY HTN‐3 Trial by Kandzari, David E., Bhatt, Deepak L., Sobotka, Paul A., O'Neill, William W., Esler, Murray, Flack, John M., Katzen, Barry T., Leon, Martin B., Massaro, Joseph M., Negoita, Manuela, Oparil, Suzanne, Rocha‐Singh, Krishna, Straley, Craig, Townsend, Raymond R., Bakris, George

“…Hypertension represents a significant global public health concern, contributing to vascular and renal morbidity, cardiovascular mortality, and economic…”
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Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial by Lobo, Melvin D, Dr, Sobotka, Paul A, Prof, Stanton, Alice, Prof, Cockcroft, John R, Prof, Sulke, Neil, MD, Dolan, Eamon, FRCPI, van der Giet, Markus, Prof, Hoyer, Joachim, Prof, Furniss, Stephen S, FRCP, Foran, John P, MD, Witkowski, Adam, MD, Januszewicz, Andrzej, Prof, Schoors, Danny, Prof, Tsioufis, Konstantinos, Prof, Rensing, Benno J, MD, Scott, Benjamin, MD, Ng, G André, Prof, Ott, Christian, MD, Schmieder, Roland E, Prof

“…Summary Background Hypertension contributes to cardiovascular morbidity and mortality. We assessed the safety and efficacy of a central iliac arteriovenous…”
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Selective vs. Global Renal Denervation: a Case for Less Is More by Fudim, Marat, Sobotka, Asher A., Yin, Yue-Hui, Wang, Joanne W., Levin, Howard, Esler, Murray, Wang, Jie, Sobotka, Paul A.

“…Purpose of Review Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some…”
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Renal sympathetic denervation for treatment of electrical storm: first-in-man experience by Ukena, Christian, Bauer, Axel, Mahfoud, Felix, Schreieck, Jürgen, Neuberger, Hans-Ruprecht, Eick, Christian, Sobotka, Paul A., Gawaz, Meinrad, Böhm, Michael

“…Introduction Sympathetic activity plays an important role in the pathogenesis of ventricular tachyarrhythmia. Catheter-based renal sympathetic denervation…”
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Renal denervation: a potential new treatment modality for polycystic ovary syndrome? by Schlaich, Markus P, Straznicky, Nora, Grima, Mariee, Ika-Sari, Carolina, Dawood, Tye, Mahfoud, Felix, Lambert, Elisabeth, Chopra, Reena, Socratous, Flora, Hennebry, Sarah, Eikelis, Nina, Böhm, Michael, Krum, Henry, Lambert, Gavin, Esler, Murray D, Sobotka, Paul A

“…OBJECTIVEPolycystic ovary syndrome (PCOS) is associated with sympathetic nervous system activation, insulin resistance, and blood pressure elevation. Renal…”
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Insurance status impacts treatment for hepatocellular carcinoma by Sobotka, Lindsay A, Hinton, Alice, Conteh, Lanla F

“…AbstractIntroduction and aimPrevious studies have identified treatment disparities in the treatment of hepatocellular carcinoma (HCC) based on insurance status…”
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Diagnosis of autism in a rare case of tyrosine hydroxylase deficiency: a case report by Reyes, Zoe Maria Dominique, Lynch, Emma, Henry, Julia, De Simone, Lenika Marina, Sobotka, Sarah A

“…Tyrosine hydroxylase deficiency (THD) is a rare movement disorder with broad phenotypic expression caused by bi-allelic mutations in the TH gene, which encode…”
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Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure by Costanzo, Maria Rosa, MD, FACC, Guglin, Maya E., MD, FACC, Saltzberg, Mitchell T., MD, FACC, Jessup, Mariell L., MD, FACC, Bart, Bradley A., MD, FACC, Teerlink, John R., MD, FACC, Jaski, Brian E., MD, FACC, Fang, James C., MD, FACC, Feller, Erika D., MD, FACC, Haas, Garrie J., MD, FACC, Anderson, Allen S., MD, FACC, Schollmeyer, Michael P., DVM, Sobotka, Paul A., MD, FACC

“…Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure Maria Rosa Costanzo, Maya E. Guglin, Mitchell T…”
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