Search Results - "Sobota, Malgorzata"
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The expression of virulence genes increases membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium
Published in PLoS biology (07-04-2022)“…Virulence gene expression can represent a substantial fitness cost to pathogenic bacteria. In the model entero-pathogen Salmonella Typhimurium (S.Tm), such…”
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Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium
Published in mBio (13-03-2024)“…Understanding the evolutionary dynamics of foodborne pathogens throughout our food production chain is of utmost importance. In this study, we reveal that…”
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Journal Article -
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Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex
Published in Molecular cell (02-04-2015)“…Small RNA-guided protein complexes play an essential role in CRISPR-mediated immunity in prokaryotes. While these complexes initiate interference by flagging…”
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Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells
Published in Genome research (01-10-2022)“…The CRISPR-Cas9 system is widely used to permanently delete genomic regions via dual guide RNAs. Genomic rearrangements induced by CRISPR-Cas9 can occur, but…”
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Journal Article