Antilung cancer activities of selenium

Selenium is considered an essential trace element in most animal and plant species, although still reported in many texts as a highly toxic material. Epidemiological investigations have reported an inverse relationship between selenium and lung cancer. Explanations of reported observations have resu...

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Bibliographic Details
Published in:	Medical hypotheses Vol. 23; no. 4; p. 443
Main Authors:	Lange, J H, Talbott, E O, Baffone, K M, Weyel, D A, Soboslay, E G, Koros, A M, Sykora, J L
Format:	Journal Article
Language:	English
Published:	United States 01-08-1987
Subjects:	Humans Lung Neoplasms - prevention & control Selenium - administration & dosage Selenium - physiology United States Water Supply United States
Online Access:	Get more information
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Summary:	Selenium is considered an essential trace element in most animal and plant species, although still reported in many texts as a highly toxic material. Epidemiological investigations have reported an inverse relationship between selenium and lung cancer. Explanations of reported observations have resulted in numerous mechanistic theories. Only recently have selenium metabolites involved in excretion been considered potential agents for antilung cancer activity. Anticancer properties have been shown in occupationally exposed copper smelter workers, dietary investigations and experimental studies. Supplementation with selenium of public water supplies, as is currently done with fluoride, is a potential method for increasing the blood concentration. This may permit development of a population prevention strategy against lung cancer and other diseases.
ISSN:	0306-9877
DOI:	10.1016/0306-9877(87)90066-1