The Occurrence of Antibodies Against Gluten in Children with Autism Spectrum Disorders Does Not Correlate with Serological Markers of Impaired Intestinal Permeability

The Occurrence of Antibodies Against Gluten in Children with Autism Spectrum Disorders Does Not Correlate with Serological Markers of Impaired Intestinal Permeability

There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which is supposed to be the effect of intestinal barrier abnormalities. The aim of study was to evaluate the relation of antibody induced by gluten to zonulin and intestinal f...

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Bibliographic Details
Published in:Journal of medicinal food Vol. 21; no. 2; p. 181
Main Authors: Józefczuk, Jan, Konopka, Ewa, Bierła, Joanna Beata, Trojanowska, Ilona, Sowińska, Agnieszka, Czarnecki, Rafał, Sobol, Lucjan, Józefczuk, Paweł, Surdy, Weronika, Cukrowska, Bożena
Format: Journal Article
Language:English
Published: United States 01-02-2018
Subjects:
Adolescent
Antibodies - blood
Autism Spectrum Disorder - blood
Autism Spectrum Disorder - immunology
Autism Spectrum Disorder - metabolism
Biomarkers - blood
Child
Child, Preschool
Cholera Toxin - immunology
Fatty Acid-Binding Proteins - immunology
Female
Glutens - immunology
Humans
Intestines - metabolism
Male
Permeability
celiac disease
celiac-specific antibodies
anti-gliadin antibodies
autistic spectrum disorders
non-celiac gluten sensitivity
anti-transglutaminase 6 antibodies
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Summary:There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which is supposed to be the effect of intestinal barrier abnormalities. The aim of study was to evaluate the relation of antibody induced by gluten to zonulin and intestinal fatty acid binding proteins (I-FABP), that is, serological markers of an impaired gut barrier. The study included 77 patients with ASDs. Zonulin, I-FABP, celiac-specific antibodies, anti-gliadin antibodies (AGA), and antibodies against neural transglutaminase 6 (TG6) of immunoglobulin (Ig) A and IgG classes were detected in sera. Celiac-specific antibodies were negative in all ASD children, four children (5.2%) had positive anti-TG6 antibodies, and increased AGA-IgG production was found in 21 patients (27.3%). Mean levels of zonulin and I-FABP in ASD patients were similar to those found in healthy controls and revealed a negative correlation with age, whereas regression analysis revealed a significant positive relationship between antibody production and the age. Serum concentrations of zonulin and I-FABP showed no statistically significant association with antibody positivity. An increased production of antibodies related to gliadin and neural TG6 in ASD children is not related to serological markers of an impaired intestinal barrier.
ISSN:1557-7600
DOI:10.1089/jmf.2017.0069