Search Results - "Sobhy, Mohamed A"

Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA by Lancey, Claudia, Tehseen, Muhammad, Bakshi, Souvika, Percival, Matthew, Takahashi, Masateru, Sobhy, Mohamed A., Raducanu, Vlad S., Blair, Kerry, Muskett, Frederick W., Ragan, Timothy J., Crehuet, Ramon, Hamdan, Samir M., De Biasio, Alfredo

“…Y-family DNA polymerase κ (Pol κ) can replicate damaged DNA templates to rescue stalled replication forks. Access of Pol κ to DNA damage sites is facilitated…”
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Manta ray foraging optimization algorithm‐based load frequency control for hybrid modern power systems by Sobhy, Mohamed A., Hasanien, Hany M., Abdelaziz, Almoataz Y., Ezzat, Mohamed

“…The regulation of the frequency and line power flow in interconnected power networks is considered to be a key aspect of load frequency control (LFC). This…”
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Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase by Sobhy, Mohamed A, Zhao, Lingyun, Anjum, Dalaver, Behzad, Ali, Takahashi, Masateru, Tehseen, Muhammad, Biasio, Alfredo De, Sougrat, Rachid, Hamdan, Samir

“…Thermostable enzymes have the potential for use in a wide variety of biotechnological applications. Cryo-electron microscopy (cryo-EM) enables the imaging of…”
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Replisome speed determines the efficiency of the Tus−Ter replication termination barrier by Elshenawy, Mohamed M., Jergic, Slobodan, Xu, Zhi-Qiang, Sobhy, Mohamed A., Takahashi, Masateru, Oakley, Aaron J., Dixon, Nicholas E., Hamdan, Samir M.

“…The Tus– Ter termination site of Escherichia coli is not completely efficient in stopping DNA replication, with about half of replisomes bypassing this…”
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Structure of Aquifex aeolicus lumazine synthase by cryo-electron microscopy to 1.42 Å resolution by Savva, Christos G, Sobhy, Mohamed A, De Biasio, Alfredo, Hamdan, Samir M

“…Single-particle cryo-electron microscopy (cryo-EM) has become an essential structural determination technique with recent hardware developments making it…”
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Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level by Sobhy, Mohamed A, Bralić, Amer, Raducanu, Vlad-Stefan, Takahashi, Masateru, Tehseen, Muhammad, Rashid, Fahad, Zaher, Manal S, Hamdan, Samir M

“…Abstract Human GEN1 is a cytosolic homologous recombination protein that resolves persisting four-way Holliday junctions (HJ) after the dissolution of the…”
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Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep‐sea brines of the Red Sea by Takahashi, Masateru, Takahashi, Etsuko, Joudeh, Luay I., Marini, Monica, Das, Gobind, Elshenawy, Mohamed M., Akal, Anastassja, Sakashita, Kosuke, Alam, Intikhab, Tehseen, Muhammad, Sobhy, Mohamed A., Stingl, Ulrich, Merzaban, Jasmeen S., Di Fabrizio, Enzo, Hamdan, Samir M.

“…ABSTRACT The deep‐sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated…”
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Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level by Sobhy, Mohamed A., Tehseen, Muhammad, Takahashi, Masateru, Bralić, Amer, De Biasio, Alfredo, Hamdan, Samir M.

“…[Display omitted] Flap endonuclease 1 (FEN1) is an important component of the intricate molecular machinery for DNA replication and repair. FEN1 is a…”
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Marine Predator Algorithm-Based Optimal PI Controllers for LVRT Capability Enhancement of Grid-Connected PV Systems by Ellithy, Hazem Hassan, Hasanien, Hany M, Alharbi, Mohammed, Sobhy, Mohamed A, Taha, Adel M, Attia, Mahmoud A

“…Photovoltaic (PV) systems are becoming essential to our energy landscape as renewable energy sources become more widely integrated into power networks…”
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Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1 by Rashid, Fahad, Harris, Paul D, Zaher, Manal S, Sobhy, Mohamed A, Joudeh, Luay I, Yan, Chunli, Piwonski, Hubert, Tsutakawa, Susan E, Ivanov, Ivaylo, Tainer, John A, Habuchi, Satoshi, Hamdan, Samir M

“…Human flap endonuclease 1 (FEN1) and related structure-specific 5'nucleases precisely identify and incise aberrant DNA structures during replication, repair…”
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The atrial FibriLlatiOn real World management registry in the Middle East and Africa: design and rationale by Sobhy, Mohamed A., Khoury, Maurice, Almahmeed, Wael A., Sah, Janvi, Di Fusco, Manuela, Mardekian, Jack, Kherraf, Sid Ahmed, Lopes, Renato D., Hersi, Ahmad

“…BACKGROUNDAtrial fibrillation is the most common cardiac arrhythmia, affecting 33.5 million patients globally. It is associated with increased morbidity,…”
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Distal radial approach between theory and clinical practice.. Time to go distal by Sanhoury, Mohamed I., Sobhy, Mohamed A., Saddaka, Mohamed A., Nassar, Mohamed A., Elwany, Mostafa N.

“…Background Transradial access (TRA), which has a minimal risk of problems such as radial artery occlusion (RAO), hemorrhage, spasm, and so on, is now…”
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Sequential and Multistep Substrate Interrogation Provides the Scaffold for Specificity in Human Flap Endonuclease 1 by Sobhy, Mohamed A., Joudeh, Luay I., Huang, Xiaojuan, Takahashi, Masateru, Hamdan, Samir M.

“…Human flap endonuclease 1 (FEN1), one of the structure-specific 5′ nucleases, is integral in replication, repair, and recombination of cellular DNA. The 5′…”
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Quick and Easy Assembly of a One-Step qRT-PCR Kit for COVID-19 Diagnostics Using In-House Enzymes by Takahashi, Masateru, Tehseen, Muhammad, Salunke, Rahul, Takahashi, Etsuko, Mfarrej, Sara, Sobhy, Mohamed A, Alhamlan, Fatimah S, Hala, Sharif, Ramos-Mandujano, Gerardo, Al-Qahtani, Ahmed A, Alofi, Fadwa S, Alsomali, Afrah, Hashem, Anwar M, Khogeer, Asim, Almontashiri, Naif A. M, Lee, Jae Man, Mon, Hiroaki, Sakashita, Kosuke, Li, Mo, Kusakabe, Takahiro, Pain, Arnab, Hamdan, Samir M

“…One-step reverse-transcription quantitative polymerase chain reaction (qRT-PCR) is the most widely applied method for COVID-19 diagnostics. Notwithstanding the…”
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Marine predators algorithm for load frequency control of modern interconnected power systems including renewable energy sources and energy storage units by Mohamed A. Sobhy, Almoataz Y. Abdelaziz, Hany M. Hasanien, Mohamed Ezzat

“…Load frequency control (LFC) serves a critical purpose in modern power systems, controlling system frequency and tie-line power flow. Nowadays, the power…”
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Do-it-yourself guide: how to use the modern single-molecule toolkit by Walter, Nils G, Huang, Cheng-Yen, Manzo, Anthony J, Sobhy, Mohamed A

“…Single-molecule microscopy has evolved into the ultimate-sensitivity toolkit to study systems from small molecules to living cells, with the prospect of…”
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Long-term prognostic implication of coronary plaque characterization as detected by 64-multidetector computed tomography in Egyptian population by Sadaka, Mohammad A., El-Sharkawy, Eman M., Sobhy, Mohamed A., Hammad, Basma A.

“…We aimed to determine the role of multi-detector computed tomography (MDCT) in prognosis of patients with known or suspected coronary artery disease (CAD) by…”
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Structure determination by cryoEM at 100 keV by McMullan, Greg, Naydenova, Katerina, Mihaylov, Daniel, Yamashita, Keitaro, Peet, Mathew J, Wilson, Hugh, Dickerson, Joshua L, Chen, Shaoxia, Cannone, Giuseppe, Lee, Yang, Hutchings, Katherine A, Gittins, Olivia, Sobhy, Mohamed A, Wells, Torquil, El-Gomati, Mohamed M, Dalby, Jason, Meffert, Matthias, Schulze-Briese, Clemens, Henderson, Richard, Russo, Christopher J

“…Electron cryomicroscopy can, in principle, determine the structures of most biological molecules but is currently limited by access, specimen preparation…”
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A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair by Bralić, Amer, Tehseen, Muhammad, Sobhy, Mohamed A, Tsai, Chi-Lin, Alhudhali, Lubna, Yi, Gang, Yu, Jina, Yan, Chunli, Ivanov, Ivaylo, Tsutakawa, Susan E, Tainer, John A, Hamdan, Samir M

“…Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and avoiding diseases. NER couples lesion recognition by XPC to strand…”
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Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway by Zaher, Manal S, Rashid, Fahad, Song, Bo, Joudeh, Luay I, Sobhy, Mohamed A, Tehseen, Muhammad, Hingorani, Manju M, Hamdan, Samir M

“…Abstract RNA-DNA hybrid primers synthesized by low fidelity DNA polymerase α to initiate eukaryotic lagging strand synthesis must be removed efficiently during…”
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