Search Results - "Soberman, R J"

CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis by Barrachina, F., Ottino, K., Tu, L. J., Soberman, R. J., Brown, D., Breton, S., Battistone, M. A.

“…Mononuclear phagocytes (MPs) play an active role in the immunological homeostasis of the urogenital tract. In the epididymis, a finely tuned balance between…”
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Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3 by ROTHENBERG, M. E, OWEN, W. F, SILBERSTEIN, D. S, WOODS, J, SOBERMAN, R. J, AUSTEN, K. F, STEVENS, R. L

“…Human eosinophils were cultured in the presence of recombinant human IL-3 for up to 14 d and their biochemical, functional, and density properties were…”
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Covalent Linkage of Prosthetic Heme to CYP4 Family P450 Enzymes by Henne, Kirk R, Kunze, Kent L, Zheng, Yi-Min, Christmas, Peter, Soberman, Roy J, Rettie, Allan E

“…An extensive body of research on the structural properties of cytochrome P450 enzymes has established that these proteins possess a b-type heme prosthetic…”
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Leukotrienes and Other Products of the 5-Lipoxygenase Pathway: Biochemistry and Relation to Pathobiology in Human Diseases by Lewis, Robert A, Austen, K. Frank, Soberman, Roy J

“…THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was chemically defined as three…”
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Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts by OWEN, W. F. JR, ROTHENBERG, M. E, SILBERSTEIN, D. S, GASSON, J. C, STEVENS, R. L, AUSTEN, K. F, SOBERMAN, R. J

“…Normodense human peripheral blood eosinophils were isolated under sterile conditions from the 22/23 and 23/24% interfaces and the cell pellet of metrizamide…”
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Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome by OWEN, W. F, ROTHENBERG, M. E, PETERSEN, J, WELLER, P. F, SILBERSTEIN, D, SHEFFER, A. L, STEVENS, R. L, SOBERMAN, R. J, AUSTEN, K. F

“…We report that the hypodense eosinophil population in three patients with corticosteroid-unresponsive IHES was uniquely long lived ex vivo in the absence of…”
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The Identification of a Distinct Export Step following the Biosynthesis of Leukotriene C4 by Human Eosinophils by Lam, B K, Owen, W F, Austen, K F, Soberman, R J

“…We have examined the requirements for the export of leukotriene C4 (LTC4) from cultured human eosinophils. To define saturability and kinetics of LTC4 export,…”
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Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes by Soberman, R J, Harper, T W, Betteridge, D, Lewis, R A, Austen, K F

“…The cytosolic fraction of human polymorphonuclear leukocytes precipitated with 60% ammonium sulfate produced 5-lipoxygenase products from [14C]arachidonic acid…”
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Purification of human leukotriene C4 synthase by Penrose, J F, Gagnon, L, Goppelt-Struebe, M, Myers, P, Lam, B K, Jack, R M, Austen, K F, Soberman, R J

“…Leukotriene (LT) C4 synthase, the enzyme that catalyzes the conjugation of LTA4 with reduced glutathione to form LTC4, was purified to homogeneity from the…”
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Synthesis and release of leukotriene C4 by human eosinophils by Owen, WF, Jr, Soberman, RJ, Yoshimoto, T, Sheffer, AL, Lewis, RA, Austen, KF

“…When human peripheral blood eosinophils isolated to 92.5% +/- 6.9 purity were stimulated with either the calcium ionophore A23187 or…”
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Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor by Rothenberg, M E, Pomerantz, J L, Owen, W F, Avraham, S, Soberman, R J, Austen, K F, Stevens, R L

“…Human eosinophils were cultured for up to 7 days in enriched medium in the absence or presence of recombinant human interleukin (IL) 3, mouse IL 5, or…”
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Properties of highly purified leukotriene C4 synthase of guinea pig lung by YOSHIMOTO, T, SOBERMAN, R. J, SPUR, B, AUSTEN, K. F

“…Leukotriene C4 (LTC4) synthase, which conjugates LTA4 and LTA4-methyl ester (LTA4-me) with glutathione (GSH) to form LTC4 and LTC4-me, respectively, has been…”
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The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes by LAM, B. K, GAGNON, L, AUSTEN, K. F, SOBERMAN, R. J

“…Recently, we characterized the export of leukotriene (LT) C4 from human eosinophils as a carrier-mediated process (Lam, B. K., Owen, W. F., Jr., Austen, K. F.,…”
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The identification and formation of 20-aldehyde leukotriene B4 by Soberman, R J, Sutyak, J P, Okita, R T, Wendelborn, D F, Roberts, L J, Austen, K F

“…Microsomes of human polymorphonuclear leukocytes (PMN) in the presence of 100 microM NADPH converted 0.6 microM leukotriene B4 (LTB4) to 20-OH-LTB4 (retention…”
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Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase by Soberman, R J, Okita, R T, Fitzsimmons, B, Rokach, J, Spur, B, Austen, K F

“…LTB4 20-hydroxylase (P-450LTB) is the cytochrome P-450 in the microsomes of human polymorphonuclear leukocytes that catalyzes the omega-oxidation of…”
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Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release by Badwey, J A, Robinson, J M, Horn, W, Soberman, R J, Karnovsky, M J, Karnovsky, M L

“…Neutrophils stimulated with optimal amounts of tumor-promoters that activate protein kinase C (e.g. mezerein, phorbol 12,13-dibutyrate) are known to release…”
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Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes by SOBERMAN, R. J, HARPER, T. W, MURPHY, R. C, AUSTEN, K. F

“…A single reaction product was formed during the incubation of 1.5 microM (5S,12R)-dihydroxy-6,14-cis-8,10-trans-[3H]icosatetraenoic acid (leukotriene B4, LTB4)…”
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Alternative Splicing Determines the Function of CYP4F3 by Switching Substrate Specificity by Christmas, Peter, Jones, Jeffrey P., Patten, Christopher J., Rock, Dan A., Zheng, Yimin, Cheng, Shing-Ming, Weber, Brittany M., Carlesso, Nadia, Scadden, David T., Rettie, Allan E., Soberman, Roy J.

“…Diversity of cytochrome P450 function is determined by the expression of multiple genes, many of which have a high degree of identity. We report that the use…”
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Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells by YOSHIMOTO, T, SOBERMAN, R. J, LEWIS, R. A, AUSTEN, K. F

“…When leukotriene (LT) A4 was incubated with subcellular fractions of sonicated rat basophilic leukemia (RBL) cells in the presence of glutathione, the enzyme…”
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Identification of an Aldehyde Dehydrogenase in the Microsomes of Human Polymorphonuclear Leukocytes That Metabolizes 20-Aldehyde Leukotriene B4 by Sutyak, J, Austen, K F, Soberman, R J

“…We have previously reported that cytochrome P-450LTB in the εsomes of human polymorphonuclear leukocytes (PMN) catalyzes three ω-oxidations of leukotriene B4…”
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