Search Results - "Sobenin, IA"

Mechanisms of medial arterial calcification in diabetes by Chistiakov, Dimitry A, Sobenin, Igor A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Medial artery calcification (MAC) is a characteristic feature of diabetes. MAC represents a concentric calcification that proceeds via matrix vesicle-nucleated…”
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Carbohydrate composition of circulating multiple-modified low-density lipoprotein by Zakiev, Emile R, Sobenin, Igor A, Sukhorukov, Vasily N, Myasoedova, Veronika A, Ivanova, Ekaterina A, Orekhov, Alexander N

“…Atherogenic modification of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis, as modified LDL, but not native LDL,…”
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The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis by Sinyov, V. V., Chicheva, M. M., Barinova, V. A., Ryzhkova, A. I., Zilinyi, R. I., Karagodin, V. P., Postnov, A. Yu, Sobenin, I. A., Orekhov, A. N., Sazonova, M. A.

“…Atherosclerosis is a polygenic socially significant disease whose risk factors include coronary heart disease, diabetes, hypertension, and myocardial…”
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Coordination in gene expression during atherogenesis by Shchelkunova, T. A., Morozov, I. A., Rubtsov, P. M., Samokhodskaya, L. M., Sobenin, I. A., Orekhov, A. N., Smirnov, A. N.

“…General tendencies in the regulation of gene expression during atherogenesis were investigated using correlation analysis for 34 mRNA species of several…”
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Carbohydrate composition of protein and lipid components in sialic acid-rich and -poor low density lipoproteins from subjects with and without coronary artery disease by Tertov, VV, Orekhov, AN, Sobenin, IA, Morrisett, JD, Gotto, AM, Guevara, JG

“…Low density lipoprotein (LDL) from patients with coronary heart disease (CHD) caused 78-286% increase in accumulation of cholesterol in human aortic…”
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Human plasma trans-sialidase causes atherogenic modification of low density lipoprotein by Tertov, V.V., Kaplun, V.V., Sobenin, I.A., Boytsova, E.Yu, Bovin, N.V., Orekhov, A.N.

“…In earlier studies we have found that incubation of low density lipoprotein (LDL) with autologous blood plasma-derived serum leads to a loss of sialic acid…”
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Changes in levels of gene expression in human aortal intima during atherogenesis by Shchelkunova, T. A., Morozov, I. A., Rubtsov, P. M., Samokhodskaya, L. M., Andrianova, I. V., Sobenin, I. A., Orekhov, A. N., Smirnov, A. N.

“…Changes in the contents of 36 mRNAs species related to lipid turnover, inflammation, metabolism and the action of sex hormones in samples of aortal intima…”
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Low-density lipoprotein modification occurring in human plasma: Possible mechanism of in vivo lipoprotein desialylation as a primary step of atherogenic modification by Tertov, V.V, Kaplun, V.V, Sobenin, I.A, Orekhov, A.N

“…We previously found in human blood a fraction of low-density lipoprotein (LDL) that is characterized by a reduced content of sialic acid. Desialylated LDL also…”
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Antiatherogenic effect of grape flavonoids in an ex vivo model by Nikitina, N A, Sobenin, I A, Myasoedova, V A, Korennaya, V V, Mel'nichenko, A A, Khalilov, E M, Orekhov, A N

“…The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from…”
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Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization by Tertov, V V, Sobenin, I A, Gabbasov, Z A, Popov, E G, Jaakkola, O, Solakivi, T, Nikkari, T, Smirnov, V N, Orekhov, A N

“…The basic differences between sialylated (sialic acid rich) and desialylated (sialic acid poor) human low density lipoproteins (LDL) are not fully defined. It…”
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Optimization of the assay for sialic acid determination in low density lipoprotein by Sobenin, I A, Tertov, V V, Orekhov, A N

“…Sialic acid level in blood plasma and circulating glycoproteins is considered to be a marker for a number of pathologic conditions, including atherosclerosis,…”
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Atherogenic modified LDL in diabetes by Sobenin, I A, Tertov, V V, Orekhov, A N

“…This paper summarizes the recent findings on LDL atherogenic modifications in diabetic patients. LDL from diabetic patients, unlike LDL from healthy subjects,…”
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Desialylation decreases the resistance of apo B-containing lipoproteins to aggregation and increases their atherogenic potential by Mel'nichenko, A A, Tertov, V V, Ivanova, O A, Aksenov, D V, Sobenin, I A, Popov, E V, Kaplun, V V, Suprun, I V, Panasenko, O M, Orekhov, A N

“…Subfractions of apo B-containing lipoproteins (VLDL and intermediate-density lipoproteins) with reduced content of sialic acid were found in human blood. These…”
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Three Types of Naturally Occurring Modified Lipoproteins Induce Intracellular Lipid Accumulation Due to Lipoprotein Aggregation by Tertov, V V, Orekhov, A N, Sobenin, I A, Gabbasov, Z A, Popov, E G, Yaroslavov, A A, Smirnov, V N

“…Low density lipoprotein (LDL) from patients with coronary atherosclerosis and diabetes mellitus as well as in vitro desialylated LDL, glycosylated LDL, and…”
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Characteristics of low density lipoprotein isolated from circulating immune complexes by Tertov, V.V., Sobenin, I.A., Orekhov, A.N., Jaakkola, O., Solakivi, T., Nikkari, T.

“…Circulating immune complexes (CIC) containing low density lipoprotein (LDL) were recently found in the blood of patients with coronary atherosclerosis. In the…”
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Allicor efficacy in lowering the risk of ischemic heart disease in primary prophylaxis by Sobenin, I A, Prianishnikov, V V, Kunnova, L M, Rabinovich, E A, Orekhov, A N

“…To assess effects of allicor (a long-acting garlic drug) on the risk of ischemic heart disease (IHD) in primary prophylaxis of cardiovascular diseases. A…”
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Antioxidant content in low density lipoprotein and lipoprotein oxidation in vivo and in vitro by Tertov, V V, Sobenin, I A, Kaplun, V V, Orekhov, A N

“…Human blood contains naturally occurring multiple-modified low density lipoprotein (nomLDL) capable of inducing the accumulation of cholesteryl esters in the…”
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Modified low density lipoprotein from diabetic patients causes cholesterol accumulation in human intimal aortic cells by Sobenin, I A, Tertov, V V, Koschinsky, T, Bünting, C E, Slavina, E S, Dedov, I I, Orekhov, A N

“…Fifty-five serum samples from 99 Type 1 and 71 serum samples from 81 Type 2 diabetic patients (56% and 88%, respectively) brought about a 1.5-3.5-fold increase…”
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Direct anti-atherosclerosis-related effects of garlic by Orekhov, A N, Tertov, V V, Sobenin, I A, Pivovarova, E M

“…Direct anti-atherosclerosis-related effects of garlic were studied using cell culture. An aqueous extract from garlic powder (GPE) was added to smooth muscle…”
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Proteolysis of apoprotein B-100 impairs its topography on LDL surface and reduces LDL association resistance by Panasenko, O M, Aksenov, D V, Mel'nichenko, A A, Suprun, I V, Yanushevskaya, E V, Vlasik, T N, Sobenin, I A, Orekhov, A N

“…Serine proteinases (trypsin and chymotrypsin) cause destruction of apolipoprotein B-100 on the surface of human blood LDL. Incubation of LDL with these enzymes…”
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