Search Results - "Sobel, B. E."

Increased plasminogen activator inhibitor-1 and vasculopathy. A reconcilable paradox by Sobel, B E

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Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome by EHRMANN, D. A, SCHNEIDER, D. J, SOBEL, B. E, CAVAGHAN, M. K, IMPERIAL, J, ROSENFIELD, R. L, POLONSKY, K. S

“…Women with polycystic ovary syndrome (PCOS) are characterized by defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis. We…”
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Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects by Kruszynska, Y T, Yu, J G, Olefsky, J M, Sobel, B E

“…Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Y…”
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Increased plasminogen activator inhibitor type 1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients : A potential factor predisposing to thrombosis and its persistence by SOBEL, B. E, WOODCOCK-MITCHELL, J, SCHNEIDER, D. J, HOLT, R. E, MARUTSUKA, K, GOLD, H

“…Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin…”
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Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients by McGill, J. B., Schneider, D. J., Arfken, C. L., Lucore, C. L., Sobel, B. E.

“…Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients. J B McGill , D J Schneider , C L Arfken , C L Lucore and B E Sobel Division…”
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Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells by NORDT, T. K, PETER, K, BODE, C, SOBEL, B. E

“…Troglitazone, a novel oral insulin sensitizer, normalizes increased plasma activity of plasminogen activator inhibitor type 1 (PAI-1) in hyperinsulinemic…”
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Stimulation in vivo of expression of intra-abdominal adipose tissue plasminogen activator inhibitor Type I by proinsulin by NORDT, T. K, BODE, C, SOBEL, B. E

“…Impaired fibrinolytic system capacity secondary to increased plasminogen activator inhibitor type-1 expression has been suggested as a pathogenetic link…”
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Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects by Calles-Escandon, J., Mirza, S. A., Sobel, B. E., Schneider, D. J.

“…Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human…”
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Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin : a potential risk factor for vascular disease by NORDT, T. K, SCHNEIDER, D. J, SOBEL, B. E

“…Both vascular disease and elevated concentrations in plasma of plasminogen activator inhibitor type-1 (PAI-1) are prominent in patients with…”
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Elaboration of type-1 plasminogen activator inhibitor from adipocytes : a potential pathogenetic link between obesity and cardiovascular disease by LUNDGREN, C. H, BROWN, S. L, NORDT, T. K, SOBEL, B. E, FUJII, S

“…Obesity is known to predispose to attenuated fibrinolysis attributable to increased concentrations in plasma of type-1 plasminogen activator inhibitor (PAI-1),…”
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Cardiovascular consequences of polycystic ovary syndrome by Amowitz, L L, Sobel, B E

“…Polycystic ovary syndrome (PCOS), a syndrome of hyperandrogenism and anovulation with numerous associated derangements, is typified by a substantially…”
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Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis by NORDT, T. K, KLASSEN, K. J, SCHNEIDER, D. J, SOBEL, B. E

“…Because of the frequent occurrence of premature cardiovascular disease in patients with non-insulin-dependent, type II diabetes mellitus (NIDDM), the…”
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Insulin resistance and thrombosis: a cardiologist’s view by Sobel, Burton E

“…Atherogenesis in the vasculature is accelerated by changes in the dynamic equilibrium between endogenous tissue plasminogen activator and plasminogen activator…”
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Induction of plasminogen activator inhibitor type-1 (PAI-1) by proinsulin and insulin in vivo by NORDT, T. K, SAWA, H, FUJII, S, SOBEL, B. E

“…Fasting hyperinsulinemia (reflected by elevations in immunoreactive "insulin") is typical of patients with non-insulin-dependent diabetes mellitus (NIDDM) and…”
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Augmentation of inhibitory effects of glycoprotein IIb-IIIa antagonists in patients with diabetes by Keating, F.K, Whitaker, D.A, Sobel, B.E, Schneider, D.J

“…Background: Patients with diabetes mellitus and acute coronary syndromes (ACS) derive enhanced benefit from treatment with glycoprotein (GP) IIb-IIIa…”
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Differential effects of anticoagulants on the activation of platelets ex vivo by SCHNEIDER, D. J, TRACY, P. B, MANN, K. G, SOBEL, B. E

“…Because activation of platelets and of the coagulation system are interdependent mediators of thrombosis, platelet activation was characterized in whole blood…”
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Paradoxical inhibition of fibrinogen binding and potentiation of α-granule release by specific types of inhibitors of glycoprotein IIb-IIIa by SCHNEIDER, D. J, TAATJES, D. J, SOBEL, B. E

“…To determine whether glycoprotein (GP) IIb-IIIa inhibitors can paradoxically augment activation of platelets, activation of GP IIb-IIIa, alpha-granule…”
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Relative efficacy of antithrombin compared with antiplatelet agents in accelerating coronary thrombolysis and preventing early reocclusion by HASKEL, E. J, PRAGER, N. A, SOBEL, B. E, ABENDSCHEIN, D. R

“…Optimal coronary thrombolysis should be prompt and persistent. Although activation of platelets and increased thrombin activity have been associated with…”
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Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor by Noda-Heiny, H, Sobel, B E

“…To determine whether thrombin directly modifies mobility of vascular smooth muscle cells (SMC), in Transwell systems (modified Boyden chambers), we exposed SMC…”
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Increased reactivity of platelets induced by fibrinogen independent of its binding to the IIb-IIIa surface glycoprotein : A potential contributor to cardiovascular risk by SCHNEIDER, D. J, TAATJES, D. J, HOWARD, D. B, SOBEL, B. E

“…To determine whether augmented activation (degranulation) of platelets might contribute to the association between higher concentrations of fibrinogen and risk…”
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