Differential effects of clonidine analogs on food intake in rabbits and monkeys

The present study examined the effect of structural analogs of clonidine on feeding in both rabbits and monkeys. In rabbits, lofexidine and tizanidine either did not influence or decreased food intake in contrast to clonidine, which stimulated food intake. Lofexidine elicited easily observed decreas...

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Bibliographic Details
Published in:	Pharmacology, biochemistry and behavior Vol. 34; no. 2; p. 433
Main Authors:	Katz, N L, Sobaski, N, Sanchez, J, Young, J E, Schlemmer, Jr, R F
Format:	Journal Article
Language:	English
Published:	United States 01-10-1989
Subjects:	Animals Clonidine - administration & dosage Clonidine - analogs & derivatives Clonidine - pharmacology Dose-Response Relationship, Drug Eating - drug effects Feeding Behavior - drug effects Female Macaca Male Rabbits Sodium Chloride - administration & dosage Sodium Chloride - pharmacology
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Summary:	The present study examined the effect of structural analogs of clonidine on feeding in both rabbits and monkeys. In rabbits, lofexidine and tizanidine either did not influence or decreased food intake in contrast to clonidine, which stimulated food intake. Lofexidine elicited easily observed decreases in motor behavior with several of the doses used in the study. Changes in motor behavior induced by tizanidine were more subtle. Conversely, lofexidine and tizanidine significantly increased feeding behavior in Stumptail macaque monkeys, as did clonidine. The results suggest that, in contrast to rabbits, Stumptail monkeys are more useful in searching for an 'orectic' effect of clonidine analogs.
ISSN:	0091-3057
DOI:	10.1016/0091-3057(89)90339-0