Search Results - "Soares da Costa, Tatiana P."

Metal‐Free Synthesis of Functional 1‐Substituted‐1,2,3‐Triazoles from Ethenesulfonyl Fluoride and Organic Azides by Giel, Marie‐Claire, Smedley, Christopher J., Mackie, Emily R. R., Guo, Taijie, Dong, Jiajia, Soares da Costa, Tatiana P., Moses, John E.

“…The boom in growth of 1,4‐disubstituted triazole products, in particular, since the early 2000’s, can be largely attributed to the birth of click chemistry and…”
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Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses by Smith, Kate M., Tsimbalyuk, Sofiya, Edwards, Megan R., Cross, Emily M., Batra, Jyoti, Soares da Costa, Tatiana P., Aragão, David, Basler, Christopher F., Forwood, Jade K.

“…Seven human isoforms of importin α mediate nuclear import of cargo in a tissue- and isoform-specific manner. How nuclear import adaptors differentially…”
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Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants by Soares da Costa, Tatiana P, Hall, Cody J, Panjikar, Santosh, Wyllie, Jessica A, Christoff, Rebecca M, Bayat, Saadi, Hulett, Mark D, Abbott, Belinda M, Gendall, Anthony R, Perugini, Matthew A

“…Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with…”
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A dual-target herbicidal inhibitor of lysine biosynthesis by Mackie, Emily RR, Barrow, Andrew S, Christoff, Rebecca M, Abbott, Belinda M, Gendall, Anthony R, Soares da Costa, Tatiana P

“…Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant…”
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Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T‐cell lymphotrophic virus‐1 (HTLV‐1) Tax1 PBM by Javorsky, Airah, Maddumage, Janesha C., Mackie, Emily R. R., Soares da Costa, Tatiana P., Humbert, Patrick O., Kvansakul, Marc

“…Scribble (Scrib) is a highly conserved cell polarity regulator that harbours potent tumour suppressor activity and plays an important role in cell migration…”
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Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria by Ottonello, Alessandra, Wyllie, Jessica A, Yahiaoui, Oussama, Sun, Shoujun, Koelln, Rebecca A, Homer, Joshua A, Johnson, Robert M, Murray, Ewan, Williams, Paul, Bolla, Jani R, Robinson, Carol V, Fallon, Thomas, Soares da Costa, Tatiana P, Moses, John E

“…The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a…”
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Structure guided design of biotin protein ligase inhibitors for antibiotic discovery by Paparella, Ashleigh S, Soares da Costa, Tatiana P, Yap, Min Y, Tieu, William, Wilce, Matthew C J, Booker, Grant W, Abell, Andrew D, Polyak, Steven W

“…Biotin protein ligase (BPL) represents a promising target for the discovery of new antibacterial chemotherapeutics. Here we review the central role of BPL for…”
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Structural insight into tanapoxvirus‐mediated inhibition of apoptosis by Suraweera, Chathura D., Anasir, Mohd Ishtiaq, Chugh, Srishti, Javorsky, Airah, Impey, Rachael E., Hasan Zadeh, Mohammad, Soares da Costa, Tatiana P., Hinds, Mark G., Kvansakul, Marc

“…Premature programmed cell death or apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Tanapoxvirus (TANV) is a…”
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Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation by Impey, Rachael E., Panjikar, Santosh, Hall, Cody J., Bock, Lucy J., Sutton, J. Mark, Perugini, Matthew A., Soares da Costa, Tatiana P.

“…Pseudomonas aeruginosa is one of the leading causes of nosocomial infections, accounting for 10% of all hospital‐acquired infections. Current antibiotics…”
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Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins by Bleackley, Mark R, Vasa, Shaily, Harvey, Peta J, Shafee, Thomas M.A, da Costa, Tatiana P. Soares, Craik, David J, Lowe, Rohan G.T, Anderson, Marilyn A

“…Plant defensins are best known for their antifungal activity and contribution to the plant immune system. The defining feature of plant defensins is their…”
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Overcoming Intrinsic and Acquired Resistance Mechanisms Associated with the Cell Wall of Gram-Negative Bacteria by Impey, Rachael E, Hawkins, Daniel A, Sutton, J Mark, Soares da Costa, Tatiana P

“…The global increase in multi-drug-resistant bacteria is severely impacting our ability to effectively treat common infections. For Gram-negative bacteria,…”
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Mis‐annotations of a promising antibiotic target in high‐priority gram‐negative pathogens by Impey, Rachael E., Lee, Mihwa, Hawkins, Daniel A., Sutton, J. Mark, Panjikar, Santosh, Perugini, Matthew A., Soares da Costa, Tatiana P.

“…The rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becoming one of the biggest…”
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Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum by Gupta, Ruchi, Hogan, Campbell J., Perugini, Matthew A., da Costa, Tatiana P. Soares

“…Wheat is an important cereal crop with an extensive role in global food supply. Given our rapidly growing population, strategies to increase the nutritional…”
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Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds by Christoff, Rebecca M, Al Bayer, Mohammad, Soares da Costa, Tatiana P, Perugini, Matthew A, Abbott, Belinda M

“…The synthesis of the first dimeric inhibitor of E. coli dihydrodipicolinate synthase (DHDPS) is reported herein. Inspired by 2,4-thiazolidinedione based…”
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Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target by Soares da Costa, Tatiana P., Desbois, Sebastien, Dogovski, Con, Gorman, Michael A., Ketaren, Natalia E., Paxman, Jason J., Siddiqui, Tanzeela, Zammit, Leanne M., Abbott, Belinda M., Robins-Browne, Roy M., Parker, Michael W., Jameson, Geoffrey B., Hall, Nathan E., Panjikar, Santosh, Perugini, Matthew A.

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the lysine biosynthesis pathway of bacteria. The pathway can be regulated by…”
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Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2 by Wines, Bruce D, Trist, Halina M, Esparon, Sandra, Impey, Rachael E, Mackay, Graham A, Andrews, Robert K, Soares da Costa, Tatiana P, Pietersz, Geoffrey A, Baker, Ross I, Hogarth, P Mark

“…FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal…”
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Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target by Christoff, Rebecca M, Gardhi, Chamodi K, Soares da Costa, Tatiana P, Perugini, Matthew A, Abbott, Belinda M

“…Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The…”
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Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity by Mackie, Emily R. R., Barrow, Andrew S., Giel, Marie-Claire, Hulett, Mark D., Gendall, Anthony R., Panjikar, Santosh, Soares da Costa, Tatiana P.

“…Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to…”
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Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus by Soares da Costa, Tatiana P., Yap, Min Y., Perugini, Matthew A., Wallace, John C., Abell, Andrew D., Wilce, Matthew C. J., Polyak, Steven W., Booker, Grant W.

“…Summary Protein biotinylation is catalysed by biotin protein ligase (BPL). The most characterized BPL is from Escherichia coli where it functions as both a…”
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Diversity in the intrinsic apoptosis pathway of nematodes by Young, Neil D., Harris, Tiffany J., Evangelista, Marco, Tran, Sharon, Wouters, Merridee A., Soares da Costa, Tatiana P., Kershaw, Nadia J., Gasser, Robin B., Smith, Brian J., Lee, Erinna F., Fairlie, W. Douglas

“…Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C…”
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