Mortality, hospitalizations, and persistence of symptoms in the outpatient setting of the first COVID-19 wave in Brazil: results of SARS-Brazil cohort study

To evaluate deaths, hospitalizations, and persistence of symptoms in patients with COVID-19 after infection in an outpatient setting during the first COVID-19 wave in Brazil. This prospective cohort was between April 2020 and February 2021. Hospitalized or non-hospitalized COVID-19 patients until fi...

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Bibliographic Details
Published in:	Einstein (São Paulo, Brazil) Vol. 22; p. eAO0652
Main Authors:	Fonseca, Henrique Andrade Rodrigues, Pereira, Adriano Jose, Nawa, Ricardo Kenji, Sant'Anna, Viviane Aparecida Rodrigues, Almeida, Tatiana Ferreira de, Guimarães, Hélio Penna, Tognon, Alexandre Pereira, Marques, Lucas Miranda, Silva, Lucas Santana Coelho da, Bittencourt, Rafaela de Souza, Gomes, Camila Pachêco, Martins, Priscila de Aquino, Oliveira, Aryadne Lyrio de, Milan, Eveline Pipolo, Dall'Orto, Frederico Toledo Campos, Hoffman Filho, Conrado Roberto, Almeida, Guacyra, Hohmann, Fábio Barlem, Moia, Diogo Duarte Fagundes, Piano, Luciana Pereira Almeida, Machado, Felipe Pinheiro, Soares, Ronaldo Vicente Pereira, Damiani, Lucas Petri, Assis, Silvia Regina Lamas, Amaro Junior, Edson, Rizzo, Luiz Vicente, Berwanger, Otávio
Format:	Journal Article
Language:	English
Published:	Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 01-01-2024
Subjects:	Adult Aged Ambulatory Care - statistics & numerical data Brazil - epidemiology Cohort Studies COVID-19 - epidemiology COVID-19 - mortality Female Hospitalization - statistics & numerical data Humans Length of Stay - statistics & numerical data Male MEDICINE, GENERAL & INTERNAL Middle Aged Original Outpatients - statistics & numerical data Prospective Studies SARS-CoV-2 Severity of Illness Index Brazil COVID-19 SARS-CoV-2 Coronavirus infections Mortality Brazil Hospitalization Long-term COVID-19 symptoms Intensive care unit Length of stay
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Summary:	To evaluate deaths, hospitalizations, and persistence of symptoms in patients with COVID-19 after infection in an outpatient setting during the first COVID-19 wave in Brazil. This prospective cohort was between April 2020 and February 2021. Hospitalized or non-hospitalized COVID-19 patients until five days after symptom onset were included. The outcomes measured were incidence of death, hospitalization, and persistence of more than two symptoms 60 days after discharge. Out of 1,198 patients enrolled in the study, 66.7% were hospitalized. A total of 289 patients died (1 [0.3%] non-hospitalized and 288 [36%] hospitalized). At 60 days, patients non-hospitalized during admission had more persistent symptoms (16.2%) compared to hospitalized (37.1%). The COVID-19 severity variables associated with the persistence of two or more symptoms were increased age (OR= 1.03; p=0.015), respiratory rate at hospital admission (OR= 1.11; p=0.005), length of hospital stay of more than 60 days (OR= 12.24; p=0.026), and need for intensive care unit admission (OR= 2.04; p=0.038). COVID-19 survivors who were older, tachypneic at admission, had a hospital length of stay >60 days, and were admitted to the intensive care unit had more persistent symptoms than patients who did not require hospitalization in the early COVID-19 waves.ClinicalTrials.gov Identifier: NCT04479488.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Conflict of interest: none. Associate Editor: Kenneth Gollob. Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. ORCID: https://orcid.org/0000-0003-4184-3867
ISSN:	1679-4508 2317-6385 2317-6385
DOI:	10.31744/einstein_journal/2024AO0652