Search Results - "Soares, Milena B. P."

New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone by Santos, Luciano de S., Silva, Valdenizia R., de Castro, Maria V. L., Dias, Rosane B., Valverde, Ludmila de F., Rocha, Clarissa A. G., Soares, Milena B. P., Quadros, Claudio A., dos Santos, Edjane R., Oliveira, Regina M. M., Carlos, Rose M., Nogueira, Paulo C. L., Bezerra, Daniel P.

“…In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen) 2 (xant)](PF 6 ) (RXC), that can eliminate colorectal cancer (CRC) stem cells by…”
Get full text

Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress by Fontes, Sheila S, Nogueira, Mateus L, Dias, Rosane B, Rocha, Clarissa A. Gurgel, Soares, Milena B. P, Vannier-Santos, Marcos A, Bezerra, Daniel P

“…Oxidative stress plays a central role in the pathophysiology of melanoma. Curcumin (CUR) is a polyphenolic phytochemical that stimulates reactive oxygen…”
Get full text

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy by Oliveira, Anna Lethicia L., Santos, Gisele G. L., Espirito-Santo, Renan F., Silva, Gessica Sabrina A., Evangelista, Afrânio F., Silva, Daniela N., Soares, Milena B. P., Villarreal, Cristiane Flora

“…Painful neuropathy is a common adverse effect of oxaliplatin (OXL), a platinum-derivative chemotherapeutic agent. Oxidative stress and mitochondrial…”
Get full text

Treatment with Benznidazole during the Chronic Phase of Experimental Chagas' Disease Decreases Cardiac Alterations by Garcia, Simone, Ramos, Carolina O, Senra, Juliana F V, Vilas-Boas, Fabio, Rodrigues, Maurício M, Campos-de-Carvalho, Antonio C, Ribeiro-Dos-Santos, Ricardo, Soares, Milena B P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Effects of umbelliferone in a murine model of allergic airway inflammation by Vasconcelos, Juliana F., Teixeira, Mauro M., Barbosa-Filho, José M., Agra, Maria F., Nunes, Xirley P., Giulietti, Ana Maria, Ribeiro-dos-Santos, Ricardo, Soares, Milena B.P.

“…The therapeutic effects of umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of…”
Get full text

A novel ruthenium complex with 5-fluorouracil suppresses colorectal cancer stem cells by inhibiting Akt/mTOR signaling by Silva, Valdenizia R., Santos, Luciano de S., de Castro, Maria V. L., Dias, Rosane B., Valverde, Ludmila de F., Rocha, Clarissa A. G., Soares, Milena B. P., Quadros, Claudio A., Correa, Rodrigo S., Batista, Alzir A., Bezerra, Daniel P.

“…[Ru(5-FU)(PPh 3 ) 2 (bipy)]PF 6 (Ru/5-FU) is a novel ruthenium complex with 5-fluorouracil with promising potential against colorectal cancer (CRC). In the…”
Get full text

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis by Dias, Ingrid R. S. B., Costa, Rafaela G. A., Rodrigues, Ana Carolina B. da C., Silva, Suellen L. R., Oliveira, Maiara de S., Soares, Milena B. P., Dias, Rosane B., Valverde, Ludmila F., Gurgel Rocha, Clarissa A., Cairns, Lauren V., Mills, Ken I., Bezerra, Daniel P.

“…Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are…”
Get full text

Ru(II)-based complexes containing 2-thiouracil derivatives suppress liver cancer stem cells by targeting NF-κB and Akt/mTOR signaling by Bomfim, Larissa M., Neves, Sara P., Coelho, Amanda M. R. M., Nogueira, Mateus L., Dias, Rosane B., Valverde, Ludmila de F., Rocha, Clarissa A. G., Soares, Milena B. P., Batista, Alzir A., Correa, Rodrigo S., Bezerra, Daniel P.

“…Cancer stem cells (CSCs) are defined as a rare population of cancer cells related to tumor initiation and maintenance. These cells are primarily responsible…”
Get full text

Antimalarial Activity of Physalins B, D, F, and G by Sá, Matheus S, de Menezes, Maria N, Krettli, Antoniana U, Ribeiro, Ivone M, Tomassini, Therezinha C. B, Ribeiro dos Santos, Ricardo, de Azevedo, Walter F, Soares, Milena B. P

“…The antimalarial activities of physalins B, D, F, and G (1–4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity…”
Get full text

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells by Silva, Suellen L. R., Dias, Ingrid R. S. B., Rodrigues, Ana Carolina B. da C., Costa, Rafaela G. A., Oliveira, Maiara de S., Barbosa, Gabriela A. da C., Soares, Milena B. P., Dias, Rosane B., Valverde, Ludmila F., Rocha, Clarissa A. G., Roy, Nainita, Park, Christopher Y., Bezerra, Daniel P.

“…Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote…”
Get full text

Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling by Rodrigues, Ana Carolina B. da C., Silva, Suellen L. R., Dias, Ingrid R. S. B., Costa, Rafaela G. A., Oliveira, Maiara de S., Soares, Milena B. P., Dias, Rosane B., Valverde, Ludmila F., Rocha, Clarissa A. G., Johnson, Emily M., Pina, Cristina, Bezerra, Daniel P.

“…Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow…”
Get full text

Eudesmol Isomers Induce Caspase‐Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells by Bomfim, Diogo S., Ferraz, Rosana P. C., Carvalho, Nanashara C., Soares, Milena B. P., Pinheiro, Maria L. B., Costa, Emmanoel V., Bezerra, Daniel P.

“…Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity…”
Get full text

Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death by Bastos, Tanira M, Barbosa, Marília I F, da Silva, Monize M, da C Júnior, José W, Meira, Cássio S, Guimaraes, Elisalva T, Ellena, Javier, Moreira, Diogo R M, Batista, Alzir A, Soares, Milena B P

“…cis-[RuCl(NO2)(dppb)(5,5'-mebipy)] (complex 1), cis-[Ru(NO2)2(dppb)(5,5'-mebipy)] (complex 2), ct-[RuCl(NO)(dppb)(5,5'-mebipy)](PF6)2 (complex 3), and…”
Get full text

Anti-Trypanosoma cruzi activity of nicotinamide by Soares, Milena B.P., Silva, Cinara V., Bastos, Tanira M., Guimarães, Elisalva T., Figueira, Claudio P., Smirlis, Despina, Azevedo, Walter F.

“…Inhibition of Trypanosoma brucei and Leishmania spp. sirtuins has shown promising antiparasitic activity, indicating that these enzymes may be used as targets…”
Get full text

Nucleobase Derivatives as Building Blocks to Form Ru(II)-Based Complexes with High Cytotoxicity by Carvalho, Diogo E. L, Oliveira, Katia M, Bomfim, Larissa M, Soares, Milena B. P, Bezerra, Daniel P, Batista, Alzir A, Correa, Rodrigo S

“…Two new Ru­(II)-based complexes containing 2-thiouracil derivatives, known as 2-thiouracil (2TU) and 6-methyl-2-thiouracil (6m2TU), were synthesized using…”
Get full text

Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis by Guimarães, Elisalva T., Lima, Milena S., Santos, Luana A., Ribeiro, Ivone M., Tomassini, Therezinha B. C., Ribeiro dos Santos, Ricardo, dos Santos, Washington L. C., Soares, Milena B. P.

“…Objectives We have previously demonstrated the immunomodulatory effects of physalins, secosteroids purified from Physalis angulata. Here we investigate the…”
Get full text

Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages by DosReis, George A, Lopes, Marcela F, Freire-de-Lima, Célio G, Nascimento, Danielle O, Soares, Milena B. P, Bozza, Patricia T, Castro-Faria-Neto, Hugo C, de Mello, Fernando G

“…After apoptosis, phagocytes prevent inflammation and tissue damage by the uptake and removal of dead cells. In addition, apoptotic cells evoke an…”
Get full text

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi by Leite, Ana Cristina Lima, de Lima, Renata Souza, Moreira, Diogo Rodrigo de M., Cardoso, Marcos Veríssimo de O., Gouveia de Brito, Ana Carolina, Farias dos Santos, Luciene Maria, Hernandes, Marcelo Zaldini, Kiperstok, Alice Costa, de Lima, Ricardo Santana, Soares, Milena B.P.

“…A novel series of thiosemicarbazone and aminoacyl-thiazolidone derivatives were synthesized. Biological evaluation indicates that some of these compounds are…”
Get full text

Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System by Villarreal, Cristiane F, Santos, Dourivaldo S, Lauria, Pedro S S, Gama, Kelly B, Espírito-Santo, Renan F, Juiz, Paulo J L, Alves, Clayton Q, David, Jorge M, Soares, Milena B P

“…Diabetic neuropathy is a frequent complication of diabetes. Symptoms include neuropathic pain and sensory alterations-no effective treatments are currently…”
Get full text

Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection by Haolla, Filipe A, Claser, Carla, de Alencar, Bruna C.G, Tzelepis, Fanny, de Vasconcelos, José Ronnie, de Oliveira, Gabriel, Silvério, Jaline C, Machado, Alexandre V, Lannes-Vieira, Joseli, Bruna-Romero, Oscar, Gazzinelli, Ricardo T, dos Santos, Ricardo Ribeiro, Soares, Milena B.P, Rodrigues, Mauricio M

“…Abstract Immunisation with Amastigote Surface Protein 2 ( asp-2 ) and trans -sialidase ( ts ) genes induces protective immunity in highly susceptible A/Sn…”
Get full text