COMBINED EXERCISE TRAINING ATTENUATES CARDIAC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF MENOPAUSE AND DIABETES

Abstract only The objective of this study was to evaluate the effects of combined (aerobic+resistance) exercise training (ET) in ovariectomized diabetic rats. Female Wistar rats were divided (n=8 each group) into: euglycemic (E), diabetic (STZ, 50 mg/kg, iv) (D), and sedentary (SOD) or trained (TOD)...

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Published in:	The FASEB journal Vol. 27; no. S1
Main Authors:	Sanches, Iris Callado, Conti, Filipe Fernandes, Soares, Marcos Rafael Rodrigues, Quinteiro, Hugo Garcia, Sirvente, Raquel, Irigoyen, Maria‐Cláudia, De Angelis, Kátia
Format:	Journal Article
Language:	English
Published:	01-04-2013
Online Access:	Get full text
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Summary:	Abstract only The objective of this study was to evaluate the effects of combined (aerobic+resistance) exercise training (ET) in ovariectomized diabetic rats. Female Wistar rats were divided (n=8 each group) into: euglycemic (E), diabetic (STZ, 50 mg/kg, iv) (D), and sedentary (SOD) or trained (TOD) ovariectomized diabetic rats. The combined ET included sessions on alternate days of aerobic exercise on treadmill and resistance exercise in ladder (40–60% of maximum capacity, 1h/d, 5d/wk, 8wk). Cardiac morphology and function were assessed by echocardiography. The animals were cannulated for arterial pressure (AP) recording and baroreflex sensitivity (BRS) assessment. The heart rate and the AP variability were analyzed in the time and frequency domain (FFT). Diabetes in ovariectomized rats increased 9% the glycemia and 20% the myocardial performance index (MPI), and reduced 14% the left ventricular shortening (SOD vs. D). The ET increased exercise capacity, attenuated the STZ‐induced LV morphometric changes, hypotension, bradycardia and BRS dysfunction, enhanced 65% the PI‐VAR, reduced 31% the MPI and 55% the SAP variability (TOD vs. SOD). In conclusion, combined exercise training induced cardiac, hemodynamic and autonomic benefits in diabetic ovariectomized rats, reinforcing the role of this approach in the management of risk factors observed in ovarian hormone deprivation associated with hyperglycemia.
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fasebj.27.1_supplement.903.2