Anti-Inflammatory, Antimicrobial, Antioxidant and Photoprotective Investigation of Red Propolis Extract as Sunscreen Formulation in Polawax Cream

Many activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently, propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic industries, mo...

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Published in:	International journal of molecular sciences Vol. 24; no. 6; p. 5112
Main Authors:	Valverde, Thalita Marcolan, Soares, Bruna Nayane Goncalves de Souza, Nascimento, Andréa Mendes do, Andrade, Ângela Leão, Sousa, Lucas Resende Dutra, Vieira, Paula Melo de Abreu, Santos, Vagner Rodrigues, Seibert, Janaína Brandão, Almeida, Tatiane Cristine Silva de, Rodrigues, Caio Fabrini, Oliveira, Samantha Roberta Machado de, Martins, Flaviano Dos Santos, Júnior, Jeronimo Geraldo Ferreira, Santos, Viviane Martins Rebello Dos
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-03-2023 MDPI
Subjects:	Annotations Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology anti-inflammatory Anti-Inflammatory Agents - therapeutic use Anti-inflammatory drugs Antibacterial activity Antifungal agents Antimicrobial agents antioxidant Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Ascomycota Biological activity Cell viability chemical composition Cytotoxicity Disease control Ethanol ethanolic extracts Flavonoids Formulations Free radicals Fungicides Gram-positive bacteria Immunoregulation Inflammation Investigations Keratinocytes Macrophages Mediation Metabolites Phenols photoprotective Phytochemicals Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Propolis Propolis - chemistry Propolis - pharmacology red propolis Room temperature Scavenging Skin Solvents Sunscreen Sunscreening Agents - pharmacology Sunscreens (Cosmetics) Tandem Mass Spectrometry Toiletries industry Ultraviolet radiation Wound healing Brazil ethanolic extracts anti-inflammatory photoprotective antioxidant chemical composition red propolis
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Summary:	Many activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently, propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic industries, motivating a better understanding of its antioxidant and anti-inflammatory activities. Propolis and its main polyphenolic compounds presented high antioxidant activity, and effectiveness as broad spectrum UVB and UVA photoprotection sunscreens. Through a qualitative phytochemical screening, the ethanolic red propolis extracts (EEPV) (70% at room temperature and 70% at a hot temperature) presented a positive result for flavonoids and terpenoids. It presented an antioxidant activity for reducing 50% of DPPH of 17 and 12 μg/mL for extraction at room temperature and at a hot temperature, respectively. The UPLC-QTOF-MS/MS analysis allowed the annotation of 40 substances for EEPV-Heated and 42 substances for EEPV-Room Temperature. The IC results of the ABTS scavenging activity was 4.7 μg/mL for both extractions, at room temperature and at a hot temperature. Additionally, we also evaluated the cytotoxic profile of propolis extracts against macrophage (RAW 264.7 cells) and keratinocytes (HaCaT cells), which showed non-cytotoxic doses in cell viability assays even after a long period of exposure. In addition, propolis extracts showed antibacterial activity for Gram-positive bacteria ( and ), demonstrating potential biological activity for the creation of formulations aimed at disease control and prevention.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24065112