Search Results - "Snykers, Sarah"

Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures by Elaut, Greetje, Henkens, Tom, Papeleu, Peggy, Snykers, Sarah, Vinken, Mathieu, Vanhaecke, Tamara, Rogiers, Vera

“…Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and relatively easy to handle in vitro system that is well-accepted for…”
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Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice by Dollé, Laurent, Best, Jan, Empsen, Christophe, Mei, Jie, Van Rossen, Elke, Roelandt, Philip, Snykers, Sarah, Najimi, Mustapha, Al Battah, Feras, Theise, Neil D., Streetz, Konrad, Sokal, Etienne, Leclercq, Isabelle A., Verfaillie, Catherine, Rogiers, Vera, Geerts, Albert, van Grunsven, Leo A.

“…The role of progenitor cells in liver repair and fibrosis has been extensively described, but their purification remains a challenge, hampering their…”
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Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation by Snykers, Sarah, Henkens, Tom, De Rop, Evelien, Vinken, Mathieu, Fraczek, Joanna, De Kock, Joery, De Prins, Evi, Geerts, Albert, Rogiers, Vera, Vanhaecke, Tamara

“…Controlling both growth and differentiation of stem cells and their differentiated somatic progeny is a challenge in numerous fields, from preclinical drug…”
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Involvement of Cell Junctions in Hepatocyte Culture Functionality by Vinken, Mathieu, Papeleu, Peggy, Snykers, Sarah, De Rop, Evelien, Henkens, Tom, Chipman, James Kevin, Rogiers, Vera, Vanhaecke, Tamara

“…In liver, like in other multicellular systems, the establishment of cellular contacts is a prerequisite for normal functioning. In particular, well-defined…”
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Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development by De Kock, Joery, Vanhaecke, Tamara, Biernaskie, Jeffrey, Rogiers, Vera, Snykers, Sarah

“…In the present study, we investigated whether precursor cells isolated from the dermis of infant human foreskin are capable to differentiate into…”
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Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology by Joanna, Fraczek, Mathieu, Vinken, Sarah, Snykers, Sarah, Deleu, Karin, Vanderkerken, Tamara, Vanhaecke, Vera, Rogiers

“…•  Introduction •  Histone Deacetylases ‐  Classification ‐  Histone‐dependent mode of action ‐  Non‐histone targets •  Cell cycle‐related histone and…”
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In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art by Snykers, Sarah, De Kock, Joery, Rogiers, Vera, Vanhaecke, Tamara

“…Stem cells are a unique source of self‐renewing cells within the human body. Before the end of the last millennium, adult stem cells, in contrast to their…”
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Manufacturing development and clinical production of NKG2D chimeric antigen receptor–expressing T cells for autologous adoptive cell therapy by Murad, Joana M, Baumeister, Susanne H, Werner, Lillian, Daley, Heather, Trébéden-Negre, Hélène, Reder, Jake, Sentman, Charles L, Gilham, David, Lehmann, Frederic, Snykers, Sarah, Sentman, Marie-Louise, Wade, Terri, Schmucker, Adam, Fanger, Michael W, Dranoff, Glenn, Ritz, Jerome, Nikiforow, Sarah

“…Abstract Background aims Adoptive cell therapy employing natural killer group 2D (NKG2D) chimeric antigen receptor (CAR)-modified T cells has demonstrated…”
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CYAD-101: An innovative non-gene edited allogeneic CAR-T for solid tumor cancer therapy by Prenen, Hans, Dekervel, Jeroen, Anguille, Sébastien, Hendlisz, Alain, Michaux, Alexandre, Sotiropoulou, Panagiota A, Gilham, David Edward, Mauen, Sébastien, Snykers, Sarah, Cerf, Emilie, Lonez, Caroline, Flament, Anne, Lehmann, Frederic, Van Cutsem, Eric

“…Abstract only 3032 Background: In contrast to autologous CAR-T cell therapies, allogeneic donor-derived CAR-T cells can be banked and used in a timely fashion…”
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Connexins and their channels in cell growth and cell death by Vinken, Mathieu, Vanhaecke, Tamara, Papeleu, Peggy, Snykers, Sarah, Henkens, Tom, Rogiers, Vera

“…Direct communication between cells, mediated by gap junctions, is nowadays considered as an indispensable mechanism in the maintenance of cellular homeostasis…”
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Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells by Snykers, Sarah, Vanhaecke, Tamara, Papeleu, Peggy, Luttun, Aernout, Jiang, Yuehua, Vander Heyden, Yvan, Verfaillie, Catherine, Rogiers, Vera

“…Differentiation of adult bone marrow stem cells (BMSC) into hepatocyte-like cells is commonly performed by continuous exposure to a cytokines-cocktail. Here,…”
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Remissions in Relapse/Refractory Acute Myeloid Leukemia Patients Following Treatment with NKG2D CAR-T Therapy without a Prior Preconditioning Chemotherapy by Sallman, David A, Kerre, Tessa, Poire, Xavier, Havelange, Violaine, Lewalle, Philippe, Davila, Marco L., Wang, Eunice S., Dekker, Doreen, Snykers, Sarah, Sotiropoulou, Panagiota A., Breman, Eytan, Braun, Nathalie, Lonez, Caroline, Verma, Bikash, Lehmann, Frédéric F., Brayer, Jason B.

“…▪ Introduction: CYAD-01 is a chimeric antigen receptor T-cell (CAR-T) product based on the receptor NKG2D with specificity for a broad range of ligands (MICA,…”
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Phase 1 Studies Assessing the Safety and Clinical Activity of Multiple Doses of a NKG2D-Based CAR-T Therapy, Cyad-01, in Acute Myeloid Leukemia by Brayer, Jason B., Sallman, David A, Kerre, Tessa, Poire, Xavier, Havelange, Violaine, Lewalle, Philippe, Wang, Eunice S., Selleslag, Dominik, Anguille, Sebastien, Beguin, Yves, Purev, Enkhtsetseg, Al-Homsi, Ahmad-Samer, Dekker, Doreen, Breman, Eytan, Sotiropoulou, Panagiota A., Snykers, Sarah, Braun, Nathalie, Lonez, Caroline, Verma, Bikash, Lehmann, Frédéric F., Davila, Marco L.

“…Introduction: CYAD-01 is a chimeric antigen receptor T-cell (CAR-T) product based on the receptor NKG2D which demonstrated anti-tumor efficacy through…”
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71. Validation of Manufacturing NKG2D Chimeric Antigen Receptor T Cells for a First-In-Human Clinical Trial in AML/MDS and Multiple Myeloma by Daley, Heather, Nikiforow, Sarah, Murad, Joana, Negre, Helene, Reider, Jake, Sentman, Charles, Snykers, Sarah, Allen, Rachel, Galinsky, Ilene, Munshi, Nikhil, Stone, Richard, Soiffer, Robert, Ritz, Jerome, Baumeister, Suzanne

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Isolation of rat hepatocytes by Papeleu, Peggy, Vanhaecke, Tamara, Henkens, Tom, Elaut, Greetje, Vinken, Mathieu, Snykers, Sarah, Rogiers, Vera

“…In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in…”
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Evaluation of the multipotent character of human adipose tissue-derived stem cells isolated by Ficoll gradient centrifugation and red blood cell lysis treatment by Al Battah, Feras, De Kock, Joery, Ramboer, Eva, Heymans, Anja, Vanhaecke, Tamara, Rogiers, Vera, Snykers, Sarah

“…► We examine lineage-specific differentiation potential of differential isolated hADSC. ► More pronounced mineral deposition observed in hADSC isolated by RBC…”
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A first-in-human phase I trial of NKG2D chimeric antigen receptor-T cells in AML/MDS and multiple myeloma by Nikiforow, Sarah, Murad, Joana, Daley, Heather, Negre, Helene, Reder, Jake, Sentman, Charles L., Lehmann, Frederic, Snykers, Sarah, Allen, Rachel, Galinsky, Ilene, Munshi, Nikhil C., Stone, Richard M., Soiffer, Robert, Ritz, Jerome, Baumeister, Susanne H.C.

“…Abstract only…”
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Safety, efficacy and quality assessment of cell therapeutic products throughout manufacturing changes by Snykers, Sarah, Willemsen, Philippe, Sapin, Valerie, Gellynck, Kris, Rommelaere, Guillaume, Dedry, Claude, Sokal, Etienne, Halioua, Eric

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Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow by Snykers, Sarah, Vanhaecke, Tamara, De Becker, Ann, Papeleu, Peggy, Vinken, Mathieu, Van Riet, Ivan, Rogiers, Vera

“…The capability of human mesenchymal stem cells (hMSC) derived of adult bone marrow to undergo in vitro hepatic differentiation was investigated. Exposure of…”
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Safety Data from a First-in-Human Phase 1 Trial of NKG2D Chimeric Antigen Receptor-T Cells in AML/MDS and Multiple Myeloma by Nikiforow, Sarah, Werner, Lillian, Murad, Joana, Jacobs, Matthew, Johnston, Lauren, Patches, Sarah, White, Randie, Daley, Heather, Negre, Helene, Reder, Jake, Sentman, Charles, Wade, Terri, Schmucker, Adam, Lehmann, Frédéric François, Snykers, Sarah, Allen, Rachel, Dipietro, Heidi, Cummings, Kristen, Galinsky, Ilene, Munshi, Nikhil C., Schlossman, Robert L., Stone, Richard M., Neuberg, Donna S., Soiffer, Robert J., Dranoff, Glenn, Ritz, Jerome, Baumeister, Susanne H.C.

“…Introduction: Conventional CAR-T cells express a single chain antibody variable fragment that restricts recognition to one tumor antigen and a limited set of…”
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