Search Results - "Snyderwine, Elizabeth G."

DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis by Schut, Herman A.J., Snyderwine, Elizabeth G.

“…The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds produced during the pyrolysis of creatine, amino acids and proteins. The major…”
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Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by Qiu, Cunping, Shan, Liang, Yu, Minshu, Snyderwine, Elizabeth G.

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor…”
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Gene expression profiling of chemically induced rat mammary gland cancer by Shan, Liang, Yu, Minshu, Snyderwine, Elizabeth G.

“…Exposure to carcinogens through diet, the atmosphere and other means is generally regarded as influencing human cancer risk, but the impact of specific…”
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Possible role of Stat5a in rat mammary gland carcinogenesis by LIANG SHAN, MINSHU YU, CLARK, Bradly D, SNYDERWINE, Elizabeth G

“…Signal transducer and activator of transcription (Stat) 5a is a transcription factor mediating the action of specific cytokines, growth factors and hormones on…”
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Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5- ]pyridine by CUNPING QIU, MINSHU YU, LIANG SHAN, SNYDERWINE, Elizabeth G

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in rats. Comparative genomic…”
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Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature by Christian, Allen T, Snyderwine, Elizabeth G, Tucker, James D

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a mutagen/carcinogen belonging to the class of heterocyclic amines (HCAs) found in cooked meats, is a…”
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Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques by Adamson, Richard H., Thorgeirsson, Unnur P., Snyderwine, Elizabeth G., Thorgeirsson, Snorri S., Reeves, Jeanette, Dalgard, Dan W., Takayama, Shozo, Sugimura, Takashi

“…ABSTRACT The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the…”
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Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation by Shan, Liang, Zhang, Renshu, Zhang, Wanghai, Lee, Edward, Sridhar, Rajagopalan, Snyderwine, Elizabeth G., Wang, Paul C.

“…We have developed an image-based technique for signal pathway analysis, target validation, and compound screening related to mammary epithelial cell…”
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Gene expression profiling in the mammary gland of rats treated with 7,12‐dimethylbenz[a]anthracene by Papaconstantinou, Andriana D., Shanmugam, Ilanchezhian, Shan, Liang, Schroeder, Insa S., Qiu, Cunping, Yu, Minshu, Snyderwine, Elizabeth G.

“…Identification of molecular markers of early‐stage breast cancer development is important for the diagnosis and prevention of the disease. In the present…”
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Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a by Papaconstantinou, Andriana D., Snyderwine, Elizabeth G.

“…In the present study we addressed whether proliferation and apoptosis in 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine-induced rat mammary gland carcinomas…”
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mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors by ROBERTS-THOMSON, S. J, SNYDERWINE, E. G

“…The mRNA differential display technique was used to compare mRNAs between normal mammary gland and tumor-derived epithelial cells from female Sprague-Dawley…”
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Id4 Regulates Mammary Epithelial Cell Growth and Differentiation and Is Overexpressed in Rat Mammary Gland Carcinomas by Shan, Liang, Yu, Minshu, Qiu, Cunping, Snyderwine, Elizabeth G.

“…Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and differentiation via regulation of basic HLH transcription factors…”
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cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene by Shan, Liang, He, Mei, Yu, Minshu, Qiu, Cunping, Lee, Norman H., Liu, Edison T., Snyderwine, Elizabeth G.

“…cDNA microarray analysis was used to examine gene expression profiles in normal female Sprague–Dawley rat mammary gland and in carcinomas induced by the cooked…”
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Susceptibility of Rats to Mammary Gland Carcinogenesis by the Food-Derived Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b]Pyridine (PhIP) Varies with Age and Is Associated with the Induction of Differential Gene Expression by Shan, Liang, Yu, Minshu, Schut, Herman A.J., Snyderwine, Elizabeth G.

“…2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP), a heterocyclic amine found in cooked meat, induces mammary gland cancer when administered to…”
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Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine by CUNPING QIU, LIANG SHAN, MINSHU YU, SNYDERWINE, Elizabeth G

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a suspected human breast carcinogen found in cooked meat that induces mammary gland cancer in rats…”
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Global Gene Expression Profiling of Chemically Induced Rat Mammary Gland Carcinomas and Adenomas by Shan, Liang, Yu, Minshu, Snyderwine, Elizabeth G.

“…Chemical carcinogens induce both benign and malignant mammary gland tumors in female Sprague-Dawley rats. To identify gene expression profiles associated with…”
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Mammary gland carcinogenesis by food-derived heterocyclic amines: Metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Snyderwine, Elizabeth G.

“…The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of…”
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H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer by Yu, Minshu, Snyderwine, Elizabeth G.

“…Laser capture microdissection, polymerase chain reaction-restriction fragment length polymorphism analysis, and DNA sequencing was used to detect H-ras codon…”
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Mammary gland carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine in rats: possible mechanisms by Snyderwine, Elizabeth G.

“…2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) is a heterocyclic amine derived from cooked meat. Mammary gland cancer can be induced in female…”
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N-acetyltransferase expression and metabolic activation on the food-derived heterocyclic amines in the human mammary gland by SADRIEH, N, DAVIS, C. D, SNYDERWINE, E. G

“…The heterocyclic amines (HCAs) found in cooked meat are procarcinogens that are metabolically activated by N-hydroxylation followed by O-acetylation by the…”
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