Search Results - "Snyder, Floyd F"

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development by Padmanabhan, Nisha, Jia, Dongxin, Geary-Joo, Colleen, Wu, Xuchu, Ferguson-Smith, Anne C., Fung, Ernest, Bieda, Mark C., Snyder, Floyd F., Gravel, Roy A., Cross, James C., Watson, Erica D.

“…The importance of maternal folate consumption for normal development is well established, yet the molecular mechanism linking folate metabolism to development…”
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Carnitine Profile Changes in Pediatric Hematopoietic Stem Cell Transplant: New Role for Carnitine? by Law, Susanna F, Fenton, Tanis R, Snyder, Floyd F, Fung, Ernest, Lewis, Victor

“…Carnitine is an essential cofactor for mitochondrial import and oxidation of fatty acids. High-dose chemotherapy and radiation, often required for…”
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Synthesis and activity of nucleoside-based antiprotozoan compounds by Tran, Huu-Anh, Zheng, Zhaoyan, Wen, Xianghui, Manivannan, Srinivasan, Pastor, Arnaud, Kaiser, Marcel, Brun, Reto, Snyder, Floyd F., Back, Thomas G.

“…[Display omitted] Parasitic protozoa employ a salvage pathway to synthesize purines and generate essential active nucleotides, whereas mammals are capable of…”
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Novel nucleoside-based antimalarial compounds by Zheng, Zhaoyan, Tran, Huu-Anh, Manivannan, Srinivasan, Wen, Xianghui, Kaiser, Marcel, Brun, Reto, Snyder, Floyd F., Back, Thomas G.

“…P. falciparum IC50 as low as 110nM with cytotoxicity toward L6 rat myoblast cell line of 111μM and a selectivity index >1000. [Display omitted] The…”
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Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans by McDonald, Megan K., Fritz, Julie-Anne, Jia, Dongxin, Scheuchner, Deborah, Snyder, Floyd F., Stanislaus, Avalyn, Curle, Jared, Li, Liang, Stabler, Sally P., Allen, Robert H., Mains, Paul E., Gravel, Roy A.

“…Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic…”
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Identification of ABC transporters acting in vitamin B 12 metabolism in Caenorhabditis elegans by McDonald, Megan K, Fritz, Julie-Anne, Jia, Dongxin, Scheuchner, Deborah, Snyder, Floyd F, Stanislaus, Avalyn, Curle, Jared, Li, Liang, Stabler, Sally P, Allen, Robert H, Mains, Paul E, Gravel, Roy A

“…Vitamin B (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic…”
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Identification, Expression, and Characterization of Escherichia coli Guanine Deaminase by Maynes, J T, Yuan, R G, Snyder, F F

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neurodegeneration in D-bifunctional protein deficiency: diagnostic clues and natural history using serial magnetic resonance imaging by Khan, Aneal, Wei, Xing-Chang, Snyder, Floyd F., Mah, Jean K., Waterham, Hans, Wanders, Ronald J. A.

“…We report serial neurodegenerative changes on neuroimaging in a rare peroxisomal disease called D-bifunctional protein deficiency. The pattern of posterior to…”
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Point Mutations at the Purine Nucleoside Phosphorylase Locus Impair Thymocyte Differentiation in the Mouse by Snyder, Floyd F., Jenuth, Jack P., Mably, Ellen R., Mangat, Rupinder K.

“…Three point mutations on the Npballele of the purine nucleoside phosphorylase locus in the mouse have been recovered by male germ cell mutagenesis. The mutants…”
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Application of Metabolomic Principles to Disorders of Nucleotide Metabolism Reveals New Metabolic Perturbations by Snyder, Floyd F., Carter, Robert J., Fung, Ernest, Hodges, Stephen D., Mantik, Kevin B.

“…A metabolomic analysis of plasma amino acids and acylcarnitines was applied to four disorders of nucleotide metabolism. Multivariate analysis gave score plots…”
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Vitamin B12 decreases, but does not normalize, homocysteine and methylmalonic acid in end-stage renal disease: A link with glycine metabolism and possible explanation of hyperhomocysteinemia in end-stage renal disease by Hyndman, Matthew Eric, Manns, Braden J., Snyder, Floyd F., Bridge, Peter J., Scott-Douglas, Nairne W., Fung, Ernest, Parsons, Howard G.

“…The genetic and environmental factors influencing catabolism of homocysteine in end-stage renal disease (ESRD) patients remain poorly understood. This study…”
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Polyethylene glycol-conjugated adenosine phosphorylase: development of alternative enzyme therapy for adenosine deaminase deficiency by Brewerton, Lee J, Fung, Ernest, Snyder, Floyd F

“…Purine nucleoside phosphorylase had previously been engineered to accept 6-amino substituted purine nucleosides by two active site substitutions, Asn243Asp;…”
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Mitochondrial Function Dependent Proliferation Assay for the Diagnosis of Mitochondrial Disorders in Human Fibroblasts by Hodges, Stephen D., Snyder, Floyd F.

“…A media has been developed which enables the assessment of mitochondrial function in fibroblasts by measuring proliferation as an end point…”
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cDNA sequence of five mouse guanine deaminase (Gda) alleles and mapping to mouse chromosome 19 by Giese, Raymond D, Snyder, Floyd F

“…Guanine deaminase catalyses the conversion of guanine to xanthine and ammonia, thereby irreversibly removing the guanine base from the pool of…”
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Cloning and Characterization of Human Guanine Deaminase by Yuan, Gang, Bin, James C., McKay, Donald J., Snyder, Floyd F.

“…Mouse erythrocyte guanine deaminase has been purified to homogeneity. The native enzyme was dimeric, being comprised of two identical subunits of approximately…”
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Modelling of purine nucleoside metabolism during mouse embryonic development: relative routes of adenosine, deoxyadenosine, and deoxyguanosine metabolism by Jenuth, J P, Mably, E R, Snyder, F F

“…The individual activities for adenosine kinase, deoxyadenosine kinase, adenosine deaminase, deoxyguanosine kinase, and purine nucleoside phosphorylase were…”
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Effects of medium-chain triglyceride feeding on energy balance in adult humans by Dias, V C, Fung, E, Snyder, F F, Carter, R J, Parsons, H G

“…In recent years, the metabolism of triglycerides has attracted much attention. Oxidation of fatty acids is an essential energy supply, especially when glucose…”
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Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9 by Jenuth, J P, Fung, E, Snyder, F F

“…Nine inbred mouse strains surveyed for erythrocytic guanosine-5'-triphosphate (GTP) concentration were found to segregate into two discrete groups. Strains…”
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T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34 + cells in ADA-deficient SCID neonates by Kohn, Donald B, Hershfield, Michal S, Carbonaro, Denise, Shigeoka, Ann, Brooks, Judith, Smogorzewska, E. Monika, Barsky, Lora W, Chan, Raymond, Burotto, Felix, Annett, Geralyn, Nolta, Jan A, Crooks, Gay, Kapoor, Neena, Eldetr, Melissa, Wara, Diane, Bowen, Thomas, Madsen, Edward, Synder, Floyd F, Bastian, John, Muul, Linda, Blaese, R. Michael, Weinberg, Kenneth, Parkman, Robertson

“…Adenosine deaminase-deficient severe combined immunodeficiency was the first disease investigated for gene therapy because of a postulated production or…”
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Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants by Mably, E R, Fung, E, Snyder, F F

“…Two independent mutations of purine nucleoside phosphorylase were identified in the first-generation progeny of male mice that had been treated with the…”
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