Search Results - "Snuderl, Matija"

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning by Coudray, Nicolas, Ocampo, Paolo Santiago, Sakellaropoulos, Theodore, Narula, Navneet, Snuderl, Matija, Fenyö, David, Moreira, Andre L., Razavian, Narges, Tsirigos, Aristotelis

“…Visual inspection of histopathology slides is one of the main methods used by pathologists to assess the stage, type and subtype of lung tumors. Adenocarcinoma…”
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T2-FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project by Patel, Sohil H, Poisson, Laila M, Brat, Daniel J, Zhou, Yueren, Cooper, Lee, Snuderl, Matija, Thomas, Cheddhi, Franceschi, Ana M, Griffith, Brent, Flanders, Adam E, Golfinos, John G, Chi, Andrew S, Jain, Rajan

“…Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on and 1p/19q mutation status. The purpose was to…”
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Whole Genome DNA Methylation Analysis of Human Glioblastoma Using Illumina BeadArrays by Serrano, Jonathan, Snuderl, Matija

“…In this chapter, we describe the use of Illumina Infinium HD Assay in conjunction with Illumina's EPIC Methylation 8-sample array platform to obtain…”
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Rapid Intraoperative Diagnosis of Pediatric Brain Tumors Using Stimulated Raman Histology by Hollon, Todd C, Lewis, Spencer, Pandian, Balaji, Niknafs, Yashar S, Garrard, Mia R, Garton, Hugh, Maher, Cormac O, McFadden, Kathryn, Snuderl, Matija, Lieberman, Andrew P, Muraszko, Karin, Camelo-Piragua, Sandra, Orringer, Daniel A

“…Accurate histopathologic diagnosis is essential for providing optimal surgical management of pediatric brain tumors. Current methods for intraoperative…”
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Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse by STYLIANOPOULOS, Triantafyllos, MARTIN, John D, SNUDERL, Matija, MPEKRIS, Fotios, JAIN, Saloni R, JAIN, Rakesh K

“…The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or…”
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Modeling Patient-Derived Glioblastoma with Cerebral Organoids by Linkous, Amanda, Balamatsias, Demosthenes, Snuderl, Matija, Edwards, Lincoln, Miyaguchi, Ken, Milner, Teresa, Reich, Batsheva, Cohen-Gould, Leona, Storaska, Andrew, Nakayama, Yasumi, Schenkein, Emily, Singhania, Richa, Cirigliano, Stefano, Magdeldin, Tarig, Lin, Ying, Nanjangud, Gouri, Chadalavada, Kalyani, Pisapia, David, Liston, Conor, Fine, Howard A.

“…The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited…”
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DNA methylation as a diagnostic tool by Galbraith, Kristyn, Snuderl, Matija

“…DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark contributing to gene expression regulation. DNA methylation patterns are…”
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DNA methylation-based classification of sinonasal undifferentiated carcinoma by Dogan, Snjezana, Vasudevaraja, Varshini, Xu, Bin, Serrano, Jonathan, Ptashkin, Ryan N., Jung, Hun Jae, Chiang, Sarah, Jungbluth, Achim A., Cohen, Marc A., Ganly, Ian, Berger, Michael F., Momeni Boroujeni, Amir, Ghossein, Ronald A., Ladanyi, Marc, Chute, Deborah J., Snuderl, Matija

“…Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy harboring IDH2 R172 mutations in >80% cases. We explored the potential of genome-wide…”
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Malignant cells facilitate lung metastasis by bringing their own soil by Duda, Dan G., Duyverman, Annique M. M. J., Kohno, Mitsutomo, Snuderl, Matija, Steller, Ernst J. A., Fukumura, Dai, Jain, Rakesh K.

“…Metastatic cancer cells (seeds) preferentially grow in the secondary sites with a permissive microenvironment (soil). We show that the metastatic cells can…”
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Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival by Kloepper, Jonas, Riedemann, Lars, Amoozgar, Zohreh, Seano, Giorgio, Susek, Katharina, Yu, Veronica, Dalvie, Nisha, Amelung, Robin L., Datta, Meenal, Song, Jonathan W., Askoxylakis, Vasileios, Taylor, Jennie W., Lu-Emerson, Christine, Batista, Ana, Kirkpatrick, Nathaniel D., Jung, Keehoon, Snuderl, Matija, Muzikansky, Alona, Stubenrauch, Kay G., Krieter, Oliver, Wakimoto, Hiroaki, Xu, Lei, Munn, Lance L., Duda, Dan G., Fukumura, Dai, Batchelor, Tracy T., Jain, Rakesh K.

“…Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously…”
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Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study by Liu, Anthony P. Y., Li, Bryan K., Pfaff, Elke, Gudenas, Brian, Vasiljevic, Alexandre, Orr, Brent A., Dufour, Christelle, Snuderl, Matija, Karajannis, Matthias A., Rosenblum, Marc K., Hwang, Eugene I., Ng, Ho-Keung, Hansford, Jordan R., Szathmari, Alexandru, Faure-Conter, Cécile, Merchant, Thomas E., Levine, Max, Bouvier, Nancy, von Hoff, Katja, Mynarek, Martin, Rutkowski, Stefan, Sahm, Felix, Kool, Marcel, Hawkins, Cynthia, Onar-Thomas, Arzu, Robinson, Giles W., Gajjar, Amar, Pfister, Stefan M., Bouffet, Eric, Northcott, Paul A., Jones, David T. W., Huang, Annie

“…Recent genomic studies have shed light on the biology and inter-tumoral heterogeneity underlying pineal parenchymal tumors, in particular pineoblastomas (PBs)…”
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Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages by Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.

“…Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)…”
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Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma by Snuderl, Matija, Fazlollahi, Ladan, Le, Long P., Nitta, Mai, Zhelyazkova, Boryana H., Davidson, Christian J., Akhavanfard, Sara, Cahill, Daniel P., Aldape, Kenneth D., Betensky, Rebecca A., Louis, David N., Iafrate, A. John

“…Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in…”
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Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome by Panwalkar, Pooja, Clark, Jonathan, Ramaswamy, Vijay, Hawes, Debra, Yang, Fusheng, Dunham, Christopher, Yip, Stephen, Hukin, Juliette, Sun, Yilun, Schipper, Matthew J., Chavez, Lukas, Margol, Ashley, Pekmezci, Melike, Chung, Chan, Banda, Adam, Bayliss, Jill M., Curry, Sarah J., Santi, Mariarita, Rodriguez, Fausto J., Snuderl, Matija, Karajannis, Matthias A., Saratsis, Amanda M., Horbinski, Craig M., Carret, Anne-Sophie, Wilson, Beverly, Johnston, Donna, Lafay-Cousin, Lucie, Zelcer, Shayna, Eisenstat, David, Silva, Marianna, Scheinemann, Katrin, Jabado, Nada, McNeely, P. Daniel, Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Hawkins, Cynthia, Korshunov, Andrey, Judkins, Alexander R., Venneti, Sriram

“…Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors…”
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Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients by Tolaney, Sara M., Boucher, Yves, Duda, Dan G., Martin, John D., Seano, Giorgio, Ancukiewicz, Marek, Barry, William T., Goel, Shom, Lahdenrata, Johanna, Isakoff, Steven J., Yeh, Eren D., Jain, Saloni R., Golshan, Mehra, Brock, Jane, Snuderl, Matija, Winer, Eric P., Krop, Ian E., Jain, Rakesh K.

“…Preoperative bevacizumab and chemotherapy may benefit a subset of breast cancer (BC) patients. To explore potential mechanisms of this benefit, we conducted a…”
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Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy by Cui, Xin, Ma, Chao, Vasudevaraja, Varshini, Serrano, Jonathan, Tong, Jie, Peng, Yansong, Delorenzo, Michael, Shen, Guomiao, Frenster, Joshua, Morales, Renee-Tyler Tan, Qian, Weiyi, Tsirigos, Aristotelis, Chi, Andrew S, Jain, Rajan, Kurz, Sylvia C, Sulman, Erik P, Placantonakis, Dimitris G, Snuderl, Matija, Chen, Weiqiang

“…Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis by Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.

“…Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair…”
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Comparison of solid tissue sequencing and liquid biopsy accuracy in identification of clinically relevant gene mutations and rearrangements in lung adenocarcinomas by Lin, Lawrence Hsu, Allison, Douglas H. R., Feng, Yang, Jour, George, Park, Kyung, Zhou, Fang, Moreira, Andre L., Shen, Guomiao, Feng, Xiaojun, Sabari, Joshua, Velcheti, Vamsidhar, Snuderl, Matija, Cotzia, Paolo

“…Screening for therapeutic targets is standard of care in the management of advanced non-small cell lung cancer. However, most molecular assays utilize tumor…”
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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer by Whitley, Melodi Javid, Cardona, Diana M, Lazarides, Alexander L, Spasojevic, Ivan, Ferrer, Jorge M, Cahill, Joan, Lee, Chang-Lung, Snuderl, Matija, Blazer, 3rd, Dan G, Hwang, E Shelley, Greenup, Rachel A, Mosca, Paul J, Mito, Jeffrey K, Cuneo, Kyle C, Larrier, Nicole A, O'Reilly, Erin K, Riedel, Richard F, Eward, William C, Strasfeld, David B, Fukumura, Dai, Jain, Rakesh K, Lee, W David, Griffith, Linda G, Bawendi, Moungi G, Kirsch, David G, Brigman, Brian E

“…Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor…”
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