Search Results - "Snoy, P J"

Establishing Efficacy of Human Products Using Animals: The US Food and Drug Administration’s “Animal Rule” by Snoy, P. J.

“…In 2002, the US Food and Drug Administration issued regulations to allow the approval of human drugs and biological products based on animal efficacy studies…”
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Postexposure Prevention of Progressive Vaccinia in SCID Mice Treated with Vaccinia Immune Globulin by Fisher, R W, Reed, J L, Snoy, P J, Mikolajczyk, M G, Bray, M, Scott, D E, Kennedy, M C

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Effect of Prior Infection with Virulent Shigella flexneri 2a on the Resistance of Monkeys to Subsequent Infection with Shigella sonnei by Formal, Samuel B., Oaks, Edwin V., Olsen, Raymond E., Wingfield-Eggleston, Michele, Snoy, Philip J., Cogan, John P.

“…All virulent shigellae have large plasmids. Plasmid-associated genes encode the expression of membrane-associated proteins (MAP), some of which correlate with…”
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Safety, immunogenicity, and efficacy in monkeys and humans of invasive Escherichia coli K-12 hybrid vaccine candidates expressing Shigella flexneri 2a somatic antigen by KOTLOFF, K. L, HERRINGTON, D. A, HALE, T. L, NEWLAND, J. W, VAN DER VERG, L, COGAN, J., SNOY, P. J, SADOFF, J. C, FORMAL, S. B, LEVINE, M. M

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Preclinical evaluation of group B Neisseria meningitidis and Escherichia coli K92 capsular polysaccharide-protein conjugate vaccines in juvenile rhesus monkeys by DEVI, S. J. N, ZOLLINGER, W. D, SNOY, P. J, TAI, J. Y, COSTANTINI, P, NORELLI, F, RAPPUOLI, R, FRASCH, C. E

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Biobehavioural correlates of hand preference in free-ranging female primates by Westergaard, G. C., Chavanne, T. J., Houser, L., Cleveland, A., Snoy, P. J., Suomi, S. J., Higley, J. D.

“…In this research we examined biological and behavioural correlates of handedness in a subject cohort of 41 free-ranging young female rhesus macaques (Macaca…”
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The Mumps Virus Neurovirulence Safety Test in Rhesus Monkeys: A Comparison of Mumps Virus Strains by Rubin, Steven A., Snoy, Philip J., Wright, Kathryn E., Brown, Earl G., Reeve, Peter, Beeler, Judy A., Carbone, Kathryn M.

“…Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test whether attenuated mumps viruses used…”
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Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid by Heyes, M P, Jordan, E K, Lee, K, Saito, K, Frank, J A, Snoy, P J, Markey, S P, Gravell, M

“…Increased concentrations of the excitotoxin quinolinic acid (QUIN) have been implicated in the neurologic deficits and brain atrophy that may accompany…”
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In Vivo Overexpression of IL-13 Receptor alpha 2 Chain Inhibits Tumorigenicity of Human Breast and Pancreatic Tumors in Immunodeficient Mice by Kawakami, Koji, Kawakami, Mariko, Snoy, P J, Husain, SR, Puri, R K

“…Interleukin 13 receptor alpha 2 (IL-13R alpha 2) chain is highly expressed on some tumor cell lines and primary cell cultures. This receptor chain plays an…”
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The effect on the safety of intravenous immunoglobulin of testing plasma for antibody to hepatitis C by Biswas, R M, Nedjar, S, Wilson, L T, Mitchell, F D, Snoy, P J, Finlayson, J S, Tankersley, D L

“…The safety of intravenous immunoglobulin (IGIV), manufactured from units testing negative for antibody to hepatitis C virus (anti-HCV), was investigated. A…”
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Evaluation of a Neonatal Rat Model for Prediction of Mumps Virus Neurovirulence in Humans by Rubin, S A, Pletnikov, M, Taffs, R, Snoy, P J, Kobasa, D, Brown, E G, Wright, K E, Carbone, K M

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Oral vaccination of monkeys with an invasive Escherichia coli K-12 hybrid expressing Shigella flexneri 2a somatic antigen by Formal, S B, Hale, T L, Kapfer, C, Cogan, J P, Snoy, P J, Chung, R, Wingfield, M E, Elisberg, B L, Baron, L S

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Superiority of the chimpanzee animal model to study the pathogenicity of known Mycoplasma pneumoniae and reputed mycoplasma pathogens by Barile, M F, Grabowski, M W, Snoy, P J, Chandler, D K

“…As far as we know, humans are the only known natural hosts for M. pneumoniae disease. Whereas volunteer studies have provided useful data on the pathogenesis…”
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Variable infections with and serologic responses of rabbits to five different HIV-1 strains, including one neural tissue isolate by Sawyer, L A, Carrow, E, Snoy, P J, Hewlett, I K, Quinnan, Jr, G V, Anand, R

“…The infectivity of different strains of HIV-1 in rabbits was investigated. The HIV-1RF and HIV-1MN inocula induced anti-envelope antibodies detectable by…”
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In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice by Kawakami, K, Kawakami, M, Snoy, P J, Husain, S R, Puri, R K

“…Interleukin 13 receptor alpha2 (IL-13R(alpha)2) chain is highly expressed on some tumor cell lines and primary cell cultures. This receptor chain plays an…”
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Physiological Correlates of Aggression and Impulsivity in Free-Ranging Female Primates by WESTERGAARD, Gregory C, SUOMI, Stephen J, CHAVANNE, Tara J, HOUSER, Lisa, HURLEY, Anne, CLEVELAND, Allison, SNOY, Philip J, HIGLEY, J. Dee

“…We examined the relations among cerebrospinal fluid (CSF) monoamine metabolite concentrations, plasma hormone concentrations, aggression, and impulsive…”
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Left versus right nipple preference in free-ranging infant rhesus macaques (Macaca mulatta) by Jaffe, Benjamin D., Evans, Theodore A., Howell, Sue, Westergaard, Gregory C., Snoy, Philip J., Higley, J. Dee

“…The examination of nonhuman primate (NHP) lateralized behaviors may provide insight into the evolution of hemispheric specialization. This study examined…”
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Oral vaccination of monkeys with an invasive Escherichia coli K-12 hybrid expressing Shigella flexneri 2a somatic antigen by FORMAL, S. B, HALE, T. L, KAPFER, C, COGAN, J. P, SNOY, P. J, CHUNG, R, WINGFIELD, M. E, ELISBERG, B. L, BARON, L. S

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