Search Results - "Snowdon, Victoria K"

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis by Ramachandran, Prakash, Pellicoro, Antonella, Vernon, Madeleine A., Boulter, Luke, Aucott, Rebecca L., Ali, Aysha, Hartland, Stephen N., Snowdon, Victoria K., Cappon, Andrea, Gordon-Walker, Timothy T., Williams, Mike J., Dunbar, Donald R., Manning, Jonathan R., van Rooijen, Nico, Fallowfield, Jonathan A., Forbes, Stuart J., Iredale, John P.

“…Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl 4 -induced model of reversible…”
Get full text

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis by Pellicoro, Antonella, Aucott, Rebecca L., Ramachandran, Prakash, Robson, Andrew J., Fallowfield, Jonathan A., Snowdon, Victoria K., Hartland, Stephen N., Vernon, Madeleine, Duffield, Jeremy S., Benyon, R. Christopher, Forbes, Stuart J., Iredale, John P.

“…Elastin has been linked to maturity of liver fibrosis. To date, the regulation of elastin secretion and its degradation in liver fibrosis has not been…”
Get full text

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo by Fallowfield, Jonathan A., Hayden, Annette L., Snowdon, Victoria K., Aucott, Rebecca L., Stutchfield, Ben M., Mole, Damian J., Pellicoro, Antonella, Gordon‐Walker, Timothy T., Henke, Alexander, Schrader, Joerg, Trivedi, Palak J., Princivalle, Marc, Forbes, Stuart J., Collins, Jane E., Iredale, John P.

“…Active myofibroblast (MF) contraction contributes significantly to the increased intrahepatic vascular resistance that is the primary cause of portal…”
Get full text

Breath Biopsy Assessment of Liver Disease Using an Exogenous Volatile Organic Compound—Toward Improved Detection of Liver Impairment by Ferrandino, Giuseppe, Orf, Isabel, Smith, Rob, Calcagno, Marzia, Thind, Anita Kaur, Debiram-Beecham, Irene, Williams, Megan, Gandelman, Olga, de Saedeleer, Alexandra, Kibble, Graham, Lydon, Anne Marie, Mayhew, Chris A., Allsworth, Max, Boyle, Billy, van der Schee, Marc P., Allison, Michael, Hoare, Matthew, Snowdon, Victoria K.

“…Liver cirrhosis and its complication - hepatocellular carcinoma (HCC) - have been associated with increased exhaled limonene. It is currently unclear whether…”
Get full text

Models and Mechanisms of Fibrosis Resolution by Snowdon, Victoria K., Fallowfield, Jonathan A.

“…Liver fibrosis and its end stage, cirrhosis, represent the final common pathway of virtually all chronic liver diseases. As our understanding of the…”
Get full text

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial by Snowdon, Victoria K, Lachlan, Neil J, Hoy, Anna M, Hadoke, Patrick W F, Semple, Scott I, Patel, Dilip, Mungall, Will, Kendall, Timothy J, Thomson, Adrian, Lennen, Ross J, Jansen, Maurits A, Moran, Carmel M, Pellicoro, Antonella, Ramachandran, Prakash, Shaw, Isaac, Aucott, Rebecca L, Severin, Thomas, Saini, Rajnish, Pak, Judy, Yates, Denise, Dongre, Neelesh, Duffield, Jeremy S, Webb, David J, Iredale, John P, Hayes, Peter C, Fallowfield, Jonathan A

“…Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal…”
Get full text

Breath Biopsy ® to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection by Ferrandino, Giuseppe, De Palo, Giovanna, Murgia, Antonio, Birch, Owen, Tawfike, Ahmed, Smith, Rob, Debiram-Beecham, Irene, Gandelman, Olga, Kibble, Graham, Lydon, Anne Marie, Groves, Alice, Smolinska, Agnieszka, Allsworth, Max, Boyle, Billy, van der Schee, Marc P, Allison, Michael, Fitzgerald, Rebecca C, Hoare, Matthew, Snowdon, Victoria K

“…The prevalence of chronic liver disease in adults exceeds 30% in some countries and there is significant interest in developing tests and treatments to help…”
Get full text

Relaxin is a renal vasodilator in experimental models of cirrhosis and a potential novel therapy for hepatorenal syndrome in man by Snowdon, Victoria K, Dr, Pellicoro, Antonella, Ramachandran, Prakash, Mungall, William, Jansen, Maurits, Lennen, Ross, Aucott, Rebecca, Kendall, Timothy, Hughes, Jeremy, Iredale, John, Fallowfield, Jonathan

“…Abstract Background Hepatorenal syndrome is a feared complication of cirrhosis, with a high mortality rate and limited treatment options. The hallmarks of the…”
Get full text

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo: Fallowfield et al by Fallowfield, Jonathan A., Hayden, Annette L., Snowdon, Victoria K., Aucott, Rebecca L., Stutchfield, Ben M., Mole, Damian J., Pellicoro, Antonella, Gordon-Walker, Timothy T., Henke, Alexander, Schrader, Joerg, Trivedi, Palak J., Princivalle, Marc, Forbes, Stuart J., Collins, Jane E., Iredale, John P.

Get full text