Search Results - "Snowden, Wendy"

Distribution of HLA‐B alleles in a Ugandan HIV‐infected adult population: NORA pharmacogenetic substudy of DART by Munderi, Paula, Snowden, Wendy B., Walker, Ann Sarah, Kityo, Cissy, Mosteller, Michael, Kabuye, Geoffrey, Thoofer, Navdeep K., Ssali, Francis, Gilks, Charles F., Hughes, Arlene R.

“…Summary Objectives  To determine the frequencies of HLA‐B alleles in Ugandan patients in the NORA substudy of the DART trial and to compare HLA‐B allele…”
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Phase I Dose Escalation Trial Evaluating the Pharmacokinetics, Anti-Human Cytomegalovirus (HCMV) Activity, and Safety of 1263W94 in Human Immunodeficiency Virus-Infected Men with Asymptomatic HCMV Shedding by LALEZARI, Jacob P, ABERG, Judith A, WANG, Laurene H, WIRE, Mary Beth, MINER, Richard, SNOWDEN, Wendy, TALARICO, Christine L, SHAW, Shuching, JACOBSON, Mark A, DREW, W. Lawrence

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Changes in Human Immunodeficiency Virus Type 1 Gag at Positions L449 and P453 Are Linked to I50V Protease Mutants In Vivo and Cause Reduction of Sensitivity to Amprenavir and Improved Viral Fitness In Vitro by Maguire, Michael F, Guinea, Rosario, Griffin, Philip, Macmanus, Sarah, Elston, Robert C, Wolfram, Josie, Richards, Naomi, Hanlon, Mary H, Porter, David J T, Wrin, Terri, Parkin, Neil, Tisdale, Margaret, Furfine, Eric, Petropoulos, Chris, Snowden, B Wendy, Kleim, Jörg-Peter

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Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial by Musiime, Victor, Kendall, Lindsay, Bakeera-Kitaka, Sabrina, Snowden, Wendy B, Odongo, Florence, Thomason, Margaret, Musoke, Philippa, Adkison, Kimberly, Burger, David, Mugyenyi, Peter, Kekitiinwa, Adeodata, Gibb, Diana M, Walker, A Sarah

“…No data on once-daily dosing of nucleoside analogues in African children currently exist. We compared the pharmacokinetics (PK) of once- versus twice-daily…”
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Emergence of Resistance to Protease Inhibitor Amprenavir in Human Immunodeficiency Virus Type 1-Infected Patients: Selection of Four Alternative Viral Protease Genotypes and Influence of Viral Susceptibility to Coadministered Reverse Transcriptase Nucleoside Inhibitors by MAGUIRE, Michael, SHORTINO, Denise, PARKER, Hayley, MAY, Jackie, SNOWDEN, Wendy, KLEIN, Astrid, HARRIS, Wendy, MANOHITHARAJAH, Varsha, TISDALE, Margaret, ELSTON, Robert, YEO, Jane, RANDALL, Sharon, FAN XU

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Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir by Harris, Wendy, Collins, Peter, Fenton, Rob J, Snowden, Wendy, Sowa, Mike, Darby, Graham

“…GlaxoSmithKline, UK Virology Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK Correspondence Rob Fenton…”
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Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus by Grey, Finn, Sowa, Mike, Collins, Peter, Fenton, Rob J, Harris, Wendy, Snowden, Wendy, Efstathiou, Stacey, Darby, Graham

“…1 Division of Virology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK 2 GlaxoSmithKline, UK Virology Medicines…”
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Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides by Rahim, S. George, Trivedi, Naimisha, Bogunovic-Batchelor, Mirjana V, Hardy, George W, Mills, Gail, Selway, John W. T, Snowden, Wendy, Littler, Edward, Coe, Paul L, Basnak, Ivan, Whale, Robert F, Walker, Richard T

“…A series of 5-substituted 2‘-deoxy-4‘-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as…”
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Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings by Campbell, Thomas B, Smeaton, Laura M, Kumarasamy, N, Flanigan, Timothy, Klingman, Karin L, Firnhaber, Cynthia, Grinsztejn, Beatriz, Hosseinipour, Mina C, Kumwenda, Johnstone, Lalloo, Umesh, Riviere, Cynthia, Sanchez, Jorge, Melo, Marineide, Supparatpinyo, Khuanchai, Tripathy, Srikanth, Martinez, Ana I, Nair, Apsara, Walawander, Ann, Moran, Laura, Chen, Yun, Snowden, Wendy, Rooney, James F, Uy, Jonathan, Schooley, Robert T, De Gruttola, Victor, Hakim, James Gita

“…Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings…”
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HIV type 1 protease cleavage site mutations and viral fitness: implications for drug susceptibility phenotyping assays by Robinson, L H, Myers, R E, Snowden, B W, Tisdale, M, Blair, E D

“…The recombinant virus assay (RVA) is a method for assessing the susceptibility of human immunodeficiency virus type 1 (HIV-1) plasma isolates to antiretroviral…”
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Once vs twice-daily abacavir and lamivudine in African children by Musiime, Victor, Kasirye, Philip, Naidoo-James, Bethany, Nahirya-Ntege, Patricia, Mhute, Tawanda, Cook, Adrian, Mugarura, Lincoln, Munjoma, Marshall, Thoofer, Navdeep K, Ndashimye, Emmanuel, Nankya, Immaculate, Spyer, Moira J, Thomason, Margaret J, Snowden, Wendy, Gibb, Diana M, Walker, Ann Sarah

“…BACKGROUND:Antiretroviral therapy (ART) adherence is critical for successful HIV treatment outcomes. Once-daily dosing could improve adherence. Plasma…”
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Once- versus twice-daily abacavir and lamivudine in African children: the randomised controlled ARROW Trial by Musiime, Victor, Kasirye, Philip, Naidoo-James, Bethany, Nahirya-Ntege, Patricia, Mhute, Tawanda, Cook, Adrian, Mugarura, Lincoln, Munjoma, Marshall, Thoofer, Navdeep K, Ndashimye, Emmanuel, Nankya, Immaculate, Spyer, Moira J., Thomason, Margaret J., Snowden, Wendy, Gibb, Diana M., Walker, A. Sarah

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Impact of Human Immunodeficiency Virus Drug Resistance Mutations Detected in Women Prior to Antiretroviral Therapy With Efavirenz + Tenofovir Disoproxil Fumarate + Lamivudine (or Emtricitabine) by Boyce, Ceejay L, Sils, Tatiana, Milne, Ross S, Wallner, Jackson J, Hardy, Samantha R, Ko, Daisy, Wong-On-Wing, Annie, Mackey, Malia, Higa, Nikki, Beck, Ingrid A, Styrchak, Sheila M, DeMarrais, Patricia, Tierney, Camlin, Fowler, Mary G, Frenkel, Lisa M

“…Abstract Background Two large studies suggest that resistance mutations to only nonnucleoside reverse transcriptase inhibitors (NNRTI) did not increase the…”
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Valacyclovir for Herpes Simplex Virus Infection: Long-Term Safety and Sustained Efficacy after 20 Years’ Experience with Acyclovir by Tyring, Stephen K., Baker, David, Snowden, Wendy

“…An extensive clinical trial program combined with 5 years’ postmarketing experience with valacyclovir provides evidence of favorable safety and efficacy in…”
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Why START? Reflections that led to the conduct of this large long‐term strategic HIV trial by Lundgren, Jens, Babiker, Abdel, Gordin, Fred, Emery, Sean, Fätkenheuer, Gerd, Molina, Jean-Michel, Wood, Robin, Neaton, James D

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Changes in HIV-1 Subtypes B and C Genital Tract RNA in Women and Men After Initiation of Antiretroviral Therapy by Fiscus, Susan A., Cu-Uvin, Susan, Eshete, Abel Tilahun, Hughes, Michael D., Bao, Yajing, Hosseinipour, Mina, Grinsztejn, Beatriz, Badal-Faesen, Sharlaa, Dragavon, Joan, Coombs, Robert W., Braun, Ken, Moran, Laura, Hakim, James, Flanigan, Timothy, Kumarasamy, N., Campbell, Thomas B.

“…Background. Combination antiretroviral therapy (cART) reduces genital tract human immunodeficiency virus type 1 (HIV-1) load and reduces the risk of sexual…”
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GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients : Absence of protease resistance at 48 weeks by MACMANUS, Sarah, YATES, Phillip J, ELSTON, Robert C, WHITE, Susan, RICHARDS, Naomi, SNOWDEN, Wendy

“…To investigate the emergence of resistance to GW433908 (908), a protease inhibitor (PI) with demonstrated antiviral efficacy, safety and tolerability, when…”
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Reducing lost to follow-up in a large clinical trial of prevention of mother-to-child transmission of HIV: The Breastfeeding, Antiretrovirals and Nutrition study experience by Sellers, Christopher J, Kayira, Dumbani, Soko, Alice, Mofolo, Innocent, Ellington, Sascha, Hudgens, Michael G, Kourtis, Athena P, King, Caroline C, Jamieson, Denise J, van der Horst, Charles, Adair, Linda, Ait-Khaled, Mounir, Albrecht, Sandra, Bangdiwala, Shrikant, Bayer, Ronald, Bramson, Brian, Bobrow, Emily, Boyle, Nicola, Butera, Sal, Chasela, Charles, Chavula, Charity, Chimerang’ambe, Joseph, Chikasema, Maria, Chikhungu, Norah, Chilongozi, David, Chiudzu, Grace, Chome, Lenesi, Cole, Anne, Corbett, Amanda, Dow, Anna, Duerr, Ann, Eliya, Henry, Ellington, Sascha, Eron, Joseph, Ferguson, Yvonne Owens, Fiscus, Susan, Flax, Valerie, Fokar, Ali, Guay, Laura, Heilig, Chad, Hooten, Elizabeth, Hurst, Stacy, Hyde, Lisa, Jamieson, Denise, Joaki, George, Jones, David, Jordan-Bell, Elizabeth, Kacheche, Zebrone, Kamanga, Gift, Kampani, Coxcilly, Kamthunzi, Portia, Kamwendo, Deborah, Kanyama, Cecilia, Kashuba, Angela, Kathyola, Damson, Kayira, Dumbani, Kourtis, Athena P., Kumwenda, Jacob, Lee, Hana, Loeliger, Edde, Luhanga, Misheck, Majawa, Maganizo, Marcus, Cheryl, Thoofer, Navdeep, Matiki, Chrissie, Mayers, Douglas, Mayuni, Isabel, McDonough, Marita, Mkomawanthu, Chimwemwe, Mndala, Ibrahim, Moses, Agnes, Msika, Albans, Msungama, Wezi, Mtimuni, Beatrice, Musis, Bonface, Mwapasa, Gerald, Nkhoma, Jacqueline, Parker, Megan, Pendame, Richard, Piwoz, Ellen, Ramdas, Zane, Rublein, John, Ryan, Mairin, Sanne, Ian, Sellers, Christopher, Sichali, Dorothy, Soko, Alice, Spensley, Allison, Tegha, Gerald, Tembo, Martin, Thomas, Roshan, Tien, Hsiao-Chuan, Tohill, Beth, van der Horst, Charles, Waalberg, Esther, Widen, Elizabeth, Wiener, Jeffrey, Wilfert, Cathy, Wiyo, Patricia, Zimba, Chifundo

“…Background/Aims Retaining patients in prevention of mother-to-child transmission of HIV studies can be challenging in resource-limited settings, where high…”
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Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months

“…Once-daily dosing of abacavir and lamivudine has been approved for adults, but paediatric data are insufficient. We conducted a pharmacokinetic study of…”
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Valacyclovir for Herpes Simplex Virus Infection: Long-Term Safety and Sustained Efficacy after 20 Years' Experience with Acyclovir by Tyring, Stephen K., Baker, David, Snowden, Wendy

“…An extensive clinical trial program combined with 5 years' postmarketing experience with valacyclovir provides evidence of favorable safety and efficacy in…”
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