Search Results - "Snowden, Martin J"

Drug–polymer intermolecular interactions in hot-melt extruded solid dispersions by Maniruzzaman, Mohammed, Morgan, David J., Mendham, Andrew P., Pang, Jiayun, Snowden, Martin J., Douroumis, Dennis

“…The purpose of the study was to investigate and identify the interactions within solid dispersions of cationic drugs and anionic polymers processed by hot-melt…”
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Continuous Cocrystallization for Dissolution Rate Optimization of a Poorly Water-Soluble Drug by Moradiya, Hiren, Islam, Muhammad T, Woollam, Grahame R, Slipper, Ian J, Halsey, Sheelagh, Snowden, Martin J, Douroumis, D

“…A continuous manufacturing process, hot melt extrusion (HME), was employed for the development of high quality carbamazepine–saccharin (CBZ–SCH) cocrystals…”
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Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing by Islam, Muhammad T., Scoutaris, Nikolaos, Maniruzzaman, Mohammed, Moradiya, Hiren G., Halsey, Sheelagh A., Bradley, Michael S.A., Chowdhry, Babur Z., Snowden, Martin J., Douroumis, Dennis

“…[Display omitted] •Implementation of PAT tools for process understanding and quality control.•NIR transmission and reflectance probes are used for first time…”
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Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug by Maniruzzaman, Mohammed, Nair, Arun, Renault, Maxcene, Nandi, Uttom, Scoutaris, Nicholaos, Farnish, Richard, Bradley, Michael S.A., Snowden, Martin J., Douroumis, Dennis

“…[Display omitted] The article describes the application of a twin-screw granulation process to enhance the dissolution rate of the poorly water soluble drug,…”
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An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs by Maniruzzaman, Mohammed, Bonnefille, Marion, Aranyos, Attila, Snowden, Martin J., Douroumis, Dennis

“…Objectives The purpose of this study was to investigate the potential of hot‐melt extrusion (HME) for masking the taste of bitter active pharmaceutical…”
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Functionalized Poly(N-isopropylacrylamide)-Based Microgels in Tumor Targeting and Drug Delivery by Campora, Simona, Mohsen, Reham, Passaro, Daniel, Samir, Howida, Ashraf, Hesham, Al-Mofty, Saif El-Din, Diab, Ayman A., El-Sherbiny, Ibrahim M., Snowden, Martin J., Ghersi, Giulio

“…Over the past several decades, the development of engineered small particles as targeted and drug delivery systems (TDDS) has received great attention thanks…”
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Vibrational spectroscopy and DFT calculations of di-amino acid cyclic peptides. Part I: cyclo(Gly-Gly), cyclo(L-Ala-L-Ala) and cyclo(L-Ala-Gly) in the solid state and in aqueous solution by Mendham, Andrew P., Dines, Trevor J., Snowden, Martin J., Chowdhry, Babur Z., Withnall, Robert

“…Investigations of the vibrational spectra of cyclo(Gly‐Gly), cyclo(L‐Ala‐L‐Ala) and cyclo(L‐Ala‐Gly) are reported. Raman scattering and Fourier transform…”
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Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray–drying processing by Loughrill, Emma, Thompson, Sharon, Owusu-Ware, Samuel, Snowden, Martin J., Douroumis, Dennis, Zand, Nazanin

“…[Display omitted] •First study to consider encapsulation of DHA in complementary food.•Microencapsulation of fish oil using a pH dependant release…”
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Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy by Ehiwe, Tracy O., Alexander, Bruce D., Mitchell, John C., Snowden, Martin J., Waters, Laura J.

“…This study investigated the development of a novel approach to surface characterization of drug poly- morphism and the extension of the capabilities of this…”
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Microgel applications and commercial considerations by Thorne, Joanna B., Vine, George J., Snowden, Martin J.

“…The term microgel has been used to describe a variety of particles that differ substantially in structure, physicochemical properties, preparation and…”
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Applications of DNP-NMR for the measurement of heteronuclear T1 relaxation times by Day, Iain J, Mitchell, John C, Snowden, Martin J, Davis, Adrian L

“…Measurement of heteronuclear spin-lattice relaxation times is hampered by both low natural abundance and low detection sensitivity. Combined with typically…”
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Calorimetric Investigation of the Influence of Cross-Linker Concentration on the Volume Phase Transition of Poly(N-isopropylacrylamide) Colloidal Microgels by Woodward, Nicola C, Chowdhry, Babur Z, Snowden, Martin J, Leharne, Stephen A, Griffiths, P. C, Winnington, Angie L

“…A series of poly(N-isopropylacrylamide) microgels were prepared, by a surfactant-free emulsion polymerization method, incorporating varying cross-linker…”
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A quality by design (QbD) twin—Screw extrusion wet granulation approach for processing water insoluble drugs by Maniruzzaman, Mohammed, Ross, Steven A., Dey, Tumpa, Nair, Arun, Snowden, Martin J., Douroumis, Dennis

“…[Display omitted] In this study, a Quality by Design (QbD) approach was used to identify the effect of formulation parameters in a twin screw wet extrusion…”
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The development of a novel smart material based on colloidal microgels and cotton by Majcen, Natasa, Mohsen, Reham, Snowden, Martin J., Mitchell, John C., Voncina, Bojana

“…Colloidal microgels are often described as “smart” due to their ability to undergo quite dramatic conformational changes in response to a change in their…”
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Theoretical Prediction of the Enantiomeric Excess in Asymmetric Catalysis. An Alignment-Independent Molecular Interaction Field Based Approach by Sciabola, Simone, Alex, Alexander, Higginson, Paul D, Mitchell, John C, Snowden, Martin J, Morao, Iñaki

“…The enantiomeric excess of three different asymmetric catalyses has been predicted in excellent agreement with the experiments using a 3D-QSPR approach. In…”
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A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation by Maniruzzaman, Mohammed, Boateng, Joshua S., Chowdhry, Babur Z., Snowden, Martin J., Douroumis, Dennis

“…Abstract The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs…”
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Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process by Rudrangi, Shashi Ravi Suman, Kaialy, Waseem, Ghori, Muhammad U., Trivedi, Vivek, Snowden, Martin J., Alexander, Bruce David

“…[Display omitted] The aim of this study was to enhance the apparent solubility and dissolution properties of flurbiprofen through inclusion complexation with…”
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Raman line mapping as a fast method for analyzing pharmaceutical bead formulations by Sasić, Slobodan, Clark, Donald A, Mitchell, John C, Snowden, Martin J

“…This paper describes the use of principal component analysis (PCA) to de-noise Raman spectra and considerably shorten data acquisition time in Raman mapping…”
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A Comparison of Catalysts to Promote Imidazolide Couplings Including the Identification of 2-Hydroxy-5-nitropyridine as a New, Safe, and Effective Catalyst by Dunn, Peter J, Hoffmann, Wilfried, Kang, Ying, Mitchell, John C, Snowden, Martin J

“…Five catalysts were compared with respect to their safety and catalytic effectiveness for promoting imidazolide couplings. Reaction rate enhancement, shock…”
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Elemental content of commercial ‘ready to-feed’ poultry and fish based infant foods in the UK by Zand, Nazanin, Chowdhry, Babur Z., Wray, David S., Pullen, Frank S., Snowden, Martin J.

“…► Primary experimental evaluation of elements in chicken and fish based infant foods. ► Inadequate intake of essential elements based on example menu…”
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