Search Results - "Snoeck, R."

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase by Topalis, D, Gillemot, S, Snoeck, R, Andrei, G

“…Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase…”
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Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia by Andrei, G., Topalis, D., De Schutter, T., Snoeck, R.

“…•Besides their antiviral properties, some acyclic nucleoside phosphonates also possess antiproliferative effects.•Cidofovir is used off-label to treat…”
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Advances in the treatment of varicella-zoster virus infections by Andrei, G, Snoeck, R

“…Varicella-zoster virus (VZV) causes two distinct diseases, varicella (chickenpox) and shingles (herpes zoster). Chickenpox occurs subsequent to primary…”
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The large tumor antigen: A “Swiss Army knife” protein possessing the functions required for the polyomavirus life cycle by Topalis, D., Andrei, G., Snoeck, R.

“…► A comparison between the L-Tag and E1 shows high similarity in the binding to the ORI. ► Polyoma- and papillomavirus helicases adopt a hexameric form to…”
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Treatment of intraurethral condylomata acuminata with surgery and cidofovir instillations in two immunocompromised patients and review of the literature by Florin, H.J., Snoeck, R., Van Cleynenbreugel, B., Albersen, M.

“…Condylomata acuminata (CA) or anogenital warts are benign proliferative lesions caused by low-risk human papillomaviruses (HPV). Treating CA can be very…”
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In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs by ANDREI, G, TOPALIS, D, FITEN, P, MCGUIGAN, C, BALZARINI, J, OPDENAKKER, G, SNOECK, R

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Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues by NAESENS, L, LENAERTS, L, ANDREI, G, SNOECK, R, VAN BEERS, D, HOLY, Antonin, BALZARINI, Jan, DE CLERCQ, Erik

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Lymphocyte‐independent pathways underlie the pathogenesis of murine cytomegalovirus‐associated secondary haemophagocytic lymphohistiocytosis by Brisse, E., Imbrechts, M., Mitera, T., Vandenhaute, J., Berghmans, N., Boon, L., Wouters, C., Snoeck, R., Andrei, G., Matthys, P.

“…Summary Haemophagocytic lymphohistiocytosis (HLH) constitutes a spectrum of immunological disorders characterized by uncontrolled immune activation and key…”
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Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses by Coen, N, Singh, U, Vuyyuru, V, Van den Oord, J J, Balzarini, J, Duraffour, S, Snoeck, R, Cheng, Y C, Chu, C K, Andrei, G

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Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication by Paramonova, M. P., Gureeva, E. S., Ozerov, A. A., Snoeck, R., Andrei, G., Alexandrov, D. A., Handazinskaya, A. L., Novikov, M. S., Kochetkov, S. N.

“…A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and…”
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Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication by Paramonova, M. P., Gureeva, E. S., Ozerov, A. A., Snoeck, R., Andrei, G., Aleksandrov, D. A., Khandazhinskaya, A. L., Novikov, M. S., Kochetkov, S. N.

“…The synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-,…”
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Activities of Different Classes of Acyclic Nucleoside Phosphonates against BK Virus in Primary Human Renal Cells by TOPALIS, D, LEBEAU, I, KRECMEROVA, M, ANDREI, G, SNOECK, R

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Antiviral therapy of herpes simplex by Snoeck, R

“…Herpes simplex virus (HSV) infections in immunocompromised patients are more severe and invasive than in non-immunocompromised patients. They are characterised…”
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Epithelial raft cultures for investigations of virus growth, pathogenesis and efficacy of antiviral agents by Andrei, G., Duraffour, S., Van den Oord, J., Snoeck, R.

“…The organotypic epithelial raft cultures, originally developed to study keratinocytes differentiation, represent a novel approach to the study of viruses able…”
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Synthesis and antiviral properties of 1-substituted 3-[ω-(4-oxoquinazolin-4(3h)-yl)alkyl]uracil derivatives by Paramonova, Maria P., Khandazhinskaya, Anastasia L., Ozerov, Alexander A., Kochetkov, Sergey N., Snoeck, Robert, Andrei, Graciela, Novikov, Mikhail S.

“…А series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was…”
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Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient by Bauters, T, Florin, L, Bordon, V, Snoeck, R, Andrei, G, Gillemot, S, Fiten, P, Opdenakker, G, Laureys, G, Padalko, E

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Antivaccinia Activities of Acyclic Nucleoside Phosphonate Derivatives in Epithelial Cells and Organotypic Cultures by SNOECK, R, HOLY, A, DEWOLF-PEETERS, C, VAN DEN OORD, J, DE CLERCQ, E, ANDREI, G

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Topical treatment of CIN 2+ by cidofovir: Results of a phase II, double-blind, prospective, placebo-controlled study by Van Pachterbeke, C, Bucella, D, Rozenberg, S, Manigart, Y, Gilles, C, Larsimont, D, Vanden Houte, K, Reynders, M, Snoeck, R, Bossens, M

“…Abstract Objective Randomized controlled trial evaluating a topical treatment for cervical intraepithelial neoplasia 2 and 3 (CIN 2+) using cidofovir. Methods…”
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The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations by Džimbeg, G., Zorc, B., Kralj, M., Ester, K., Pavelić, K., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E., Mintas, M.

“…The novel urea primaquine derivatives 3a– i were prepared by aminolysis of benzotriazolide 2 with the corresponding amine in the presence or absence of…”
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Activities of Acyclic Nucleoside Phosphonates against Orf Virus in Human and Ovine Cell Monolayers and Organotypic Ovine Raft Cultures by DAL POZZO, F, ANDREI, G, HOLY, A, VAN DEN OORD, J, SCAGLIARINI, A, DE CLERCQ, E, SNOECK, R

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