Search Results - "Snipas, Scott"

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation by Burgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian, Benarafa, Charaf

“…Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and…”
Get full text

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design by Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J, El Oualid, Farid, Huang, Tony T, Bekes, Miklos, Drag, Marcin, Olsen, Shaun K

“…Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target for the development of antiviral…”
Get full text

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11 by Bibo-Verdugo, Betsaida, Snipas, Scott J., Kolt, Sonia, Poreba, Marcin, Salvesen, Guy S.

“…Pyroptosis is the caspase-dependent inflammatory cell death mechanism that underpins the innate immune response against pathogens and is dysregulated in…”
Get full text

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling by Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O’Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie R., Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne P., Snipas, Scott J., Salvesen, Guy S., Morris, Lucy X., Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward M., Goodnow, Christopher C., Dixit, Vishva M.

“…Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli , Salmonella typhimurium , Shigella flexneri , and Burkholderia…”
Get full text

Caspase selective reagents for diagnosing apoptotic mechanisms by Poreba, Marcin, Groborz, Katarzyna, Navarro, Mario, Snipas, Scott J., Drag, Marcin, Salvesen, Guy S.

“…Apical caspases initiate and effector caspases execute apoptosis. Reagents that can distinguish between caspases, particularly apical caspases-8, 9, and 10 are…”
Get full text

NETosis occurs independently of neutrophil serine proteases by Kasperkiewicz, Paulina, Hempel, Anne, Janiszewski, Tomasz, Kołt, Sonia, Snipas, Scott J., Drag, Marcin, Salvesen, Guy S.

“…Neutrophils are primary host innate immune cells defending against pathogens. One proposed mechanism by which neutrophils prevent the spread of pathogens is…”
Get full text

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1 by Ramirez, Monica L. Gonzalez, Poreba, Marcin, Snipas, Scott J., Groborz, Katarzyna, Drag, Marcin, Salvesen, Guy S.

“…Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is executed by caspase-1 (in the canonical pyroptosis pathway) or…”
Get full text

Cell organelles are retained inside pyroptotic corpses during inflammatory cell death by Hempel, Anne, D'Osualdo, Andrea, Snipas, Scott J, Salvesen, Guy S

“…Many proinflammatory proteins are released via the necrotic form of cell death known as pyroptosis. Sometimes known as gasdermin D (GSDMD) dependent cell…”
Get full text

Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells by Groborz, Katarzyna M, Kalinka, Małgorzata, Grzymska, Justyna, Kołt, Sonia, Snipas, Scott J, Poręba, Marcin

“…Activated effector caspases 3, 6 and 7 are responsible for cleaving a number of target substrates, leading to the ultimate destruction of cells apoptosis. The…”
Get full text

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling by Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J., Parker, Heather, Winterbourn, Christine C., Salvesen, Guy S., Drag, Marcin

“…The exploration of protease substrate specificity is generally restricted to naturally occurring amino acids, limiting the degree of conformational space that…”
Get full text

NETosis occurs independently of neutrophil serine proteases by Kasperkiewicz, Paulina, Hempel, Anne, Janiszewski, Tomasz, Kołt, Sonia, Snipas, Scott J, Drag, Marcin, Salvesen, Guy S

“…Neutrophils are primary host innate immune cells defending against pathogens. One proposed mechanism by which neutrophils prevent the spread of pathogens is…”
Get full text

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4 by Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J, Lin, S Jack, Kirchhofer, Daniel, Salvesen, Guy S, Drag, Marcin

“…Human neutrophil serine protease 4 (NSP4), also known as PRSS57, is a recently discovered fourth member of the neutrophil serine proteases family. Although its…”
Get full text

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes by Poreba, Marcin, Solberg, Rigmor, Rut, Wioletta, Lunde, Ngoc Nguyen, Kasperkiewicz, Paulina, Snipas, Scott J, Mihelic, Marko, Turk, Dusan, Turk, Boris, Salvesen, Guy S, Drag, Marcin

“…Legumain (AEP) is a lysosomal cysteine protease that was first characterized in leguminous seeds and later discovered in higher eukaryotes. AEP upregulation is…”
Get more information

Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome by Snipas, Scott J, Jappelli, Roberto, Torkamani, Ali, Paternostro, Giovanni, Salvesen, Guy S

“…A patient diagnosed with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome underwent whole-exome sequencing seeking a unified genetic…”
Get more information

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion by Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.

“…Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of…”
Get full text

Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes by Poreba, Marcin, Groborz, Katarzyna M., Rut, Wioletta, Pore, Milind, Snipas, Scott J., Vizovisek, Matej, Turk, Boris, Kuhn, Peter, Drag, Marcin, Salvesen, Guy S.

“…The subset of the proteome that contains enzymes in their catalytically active form can be interrogated by using probes targeted toward individual specific…”
Get full text

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells by Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Snipas, Scott J., Salvesen, Guy S., Drag, Marcin

“…Most caspases can be positioned unambiguously within the regulated cell death networks of apoptosis and pyroptosis, but the role of caspase-2, a highly…”
Get full text

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes by Janiszewski, Tomasz, Kołt, Sonia, Kaiserman, Dion, Snipas, Scott J., Li, Shuang, Kulbacka, Julita, Saczko, Jolanta, Bovenschen, Niels, Salvesen, Guy, Drąg, Marcin, Bird, Phillip I., Kasperkiewicz, Paulina

“…Natural killer (NK) cells are key innate immunity effectors that combat viral infections and control several cancer types. For their immune function, human NK…”
Get full text

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy by Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

“…Genetic polymorphisms in the region of the trimeric serine hydrolase high-temperature requirement 1 (HTRA1) are associated with increased risk of age-related…”
Get full text

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes by Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J, Bekes, Miklos, Huang, Tony T, Drag, Marcin

“…Deubiquitinating enzymes (DUBs) are responsible for removing ubiquitin (Ub) from its protein conjugates. DUBs have been implicated as attractive therapeutic…”
Get full text