Search Results - "Snijders, Peter Jf"
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Risk of recurrent high-grade cervical intraepithelial neoplasia after successful treatment: a long-term multi-cohort study
Published in The lancet oncology (01-05-2011)“…Summary Background 15% of women treated for high-grade cervical intraepithelial neoplasia (CIN grade 2 or 3) develop residual or recurrent CIN grade 2 or 3 or…”
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Factors affecting transmission of mucosal human papillomavirus
Published in The Lancet infectious diseases (01-12-2010)“…Summary Human papillomavirus (HPV) is the most common sexually transmitted infection. The effect of HPV on public health is especially related to the burden of…”
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Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
Published in The lancet oncology (2012)“…Summary Background Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV…”
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hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
Published in BMC cancer (09-06-2010)“…Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical…”
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Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
Published in Molecular cancer (26-06-2010)“…A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an…”
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Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape
Published in BMC cancer (23-11-2012)“…Quantitative methylation-specific PCR (qMSP) analysis for determining the methylation status of (candidate) tumor suppressor genes has potential as objective…”
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PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
Published in Molecular cancer (10-06-2011)“…High-risk human papillomavirus (hrHPV) infections are causally related to cervical cancer development. The additional (epi)genetic alterations driving…”
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HPV-mediated cervical carcinogenesis: concepts and clinical implications
Published in The Journal of pathology (01-01-2006)“…Persistent infection with a high‐risk human papillomavirus (hrHPV) is generally accepted as a necessary cause of cervical cancer. However, cervical cancer is a…”
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Human papillomavirus infection in women with and without cervical cancer in Ibadan, Nigeria
Published in Infectious agents and cancer (03-12-2010)“…Concerns have been raised that the proportion of cervical cancer preventable by human papillomavirus (HPV) 16/18 vaccines might be lower in sub-Saharan Africa…”
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Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis
Published in The Journal of pathology (01-09-2013)“…Transformation of epithelial cells by high‐risk human papillomavirus (hrHPV) types can lead to anogenital carcinomas, particularly cervical cancer, and…”
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Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
Published in BMC medical genomics (01-06-2009)“…It is well known that a persistent infection with high-risk human papillomavirus (hrHPV) is causally involved in the development of squamous cell carcinomas of…”
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HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia
Published in BMC cancer (24-01-2012)“…The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent…”
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13
High-risk HPV infection after five years in a population-based cohort of Chilean women
Published in Infectious agents and cancer (16-11-2011)“…The need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (HPV):…”
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Human papillomavirus prevalence in invasive cervical carcinoma by HIV Status
Published in Infectious agents and cancer (19-04-2012)“…Doc number: O12…”
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Somatic mutation in PIK3CA is a late event in cervical carcinogenesis
Published in The journal of pathology. Clinical research (01-10-2015)“…Somatic mutations in cervical intraepithelial neoplasia (CIN) are largely unknown. Here, we profiled 35 cervical carcinomas and 23 CIN grade 2/3 (CIN2/3) for…”
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Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions
Published in Nature reviews. Cancer (01-06-2014)“…Key Points Cervical intraepithelial neoplasia (CIN) lesions can be divided into productive (CIN1 and CIN2) and transforming (CIN2 and CIN3) lesions…”
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Human Papillomavirus and Diseases of the Upper Airway: Head and Neck Cancer and Respiratory Papillomatosis
Published in Vaccine (20-11-2012)“…Highlights ► HPV16 is necessary for initiation/malignant phenotype of some oropharynx cancers. ► Infection by HPV16 is associated with elevated odds of…”
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Cervical cancer risk in HPV‐positive women after a negative FAM19A4/mir124‐2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow‐up
Published in International journal of cancer (15-09-2018)“…DNA methylation analysis of cervical scrapes using FAM19A4 and mir124‐2 genes has shown a good clinical performance in detecting cervical cancer and advanced…”
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High‐risk HPV testing on self‐sampled versus clinician‐collected specimens: A review on the clinical accuracy and impact on population attendance in cervical cancer screening
Published in International journal of cancer (15-05-2013)“…This review elaborates on the accuracy and feasibility of human papillomavirus (HPV) self‐sampling, i.e., offering self‐sampling of (cervico‐)vaginal cell…”
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Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer
Published in Clinical cancer research (15-07-2017)“…Epigenetic host cell changes involved in cervical cancer development following a persistent high-risk human papillomavirus (hrHPV) infection, provide promising…”
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