Search Results - "Snijder, Eric J"

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design by Malone, Brandon, Urakova, Nadya, Snijder, Eric J., Campbell, Elizabeth A.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to cause massive global upheaval. Coronaviruses are…”
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Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements by Manfredonia, Ilaria, Nithin, Chandran, Ponce-Salvatierra, Almudena, Ghosh, Pritha, Wirecki, Tomasz K, Marinus, Tycho, Ogando, Natacha S, Snijder, Eric J, van Hemert, Martijn J, Bujnicki, Janusz M, Incarnato, Danny

“…Abstract SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outbreak caused the ongoing COVID-19 pandemic. The…”
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A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis by Snijder, Eric J, Limpens, Ronald W A L, de Wilde, Adriaan H, de Jong, Anja W M, Zevenhoven-Dobbe, Jessika C, Maier, Helena J, Faas, Frank F G A, Koster, Abraham J, Bárcena, Montserrat

“…Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave…”
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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2 by Ogando, Natacha S, Zevenhoven-Dobbe, Jessika C, van der Meer, Yvonne, Bredenbeek, Peter J, Posthuma, Clara C, Snijder, Eric J

“…Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional…”
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A molecular pore spans the double membrane of the coronavirus replication organelle by Wolff, Georg, Limpens, Ronald W. A. L., Zevenhoven-Dobbe, Jessika C., Laugks, Ulrike, Zheng, Shawn, de Jong, Anja W. M., Koning, Roman I., Agard, David A., Grünewald, Kay, Koster, Abraham J., Snijder, Eric J., Bárcena, Montserrat

“…Viral RNA exported from the coronavirus replication organelle is likely to be mediated by a crown-shaped molecular pore. A gateway to the cytosol Coronaviruses…”
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SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology by Ogando, Natacha S, Dalebout, Tim J, Zevenhoven-Dobbe, Jessika C, Limpens, Ronald W A L, van der Meer, Yvonne, Caly, Leon, Druce, Julian, de Vries, Jutte J C, Kikkert, Marjolein, Bárcena, Montserrat, Sidorov, Igor, Snijder, Eric J

“…The sudden emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the end of 2019 from the Chinese province of Hubei and its subsequent…”
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In vitro reconstitution of SARS-coronavirus mRNA cap methylation by Bouvet, Mickaël, Debarnot, Claire, Imbert, Isabelle, Selisko, Barbara, Snijder, Eric J, Canard, Bruno, Decroly, Etienne

“…SARS-coronavirus (SARS-CoV) genome expression depends on the synthesis of a set of mRNAs, which presumably are capped at their 5' end and direct the synthesis…”
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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity by Ogando, Natacha S, Ferron, Francois, Decroly, Etienne, Canard, Bruno, Posthuma, Clara C, Snijder, Eric J

“…Among RNA viruses, the order stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing…”
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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities by Subissi, Lorenzo, Posthuma, Clara C, Collet, Axelle, Zevenhoven-Dobbe, Jessika C, Gorbalenya, Alexander E, Decroly, Etienne, Snijder, Eric J, Canard, Bruno, Imbert, Isabelle

“…Significance The 2003 severe acute respiratory syndrome (SARS) epidemic and recent emergence of Middle East respiratory syndrome highlight the potential…”
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Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture by DE WILDE, Adriaan H, JOCHMANS, Dirk, POSTHUMA, Clara C, ZEVENHOVEN-DOBBE, Jessika C, VAN NIEUWKOOP, Stefan, BESTEBROER, Theo M, VAN DEN HOOGEN, Bernadette G, NEYTS, Johan, SNIJDER, Eric J

“…Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome…”
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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity by Schoggins, John W., MacDuff, Donna A., Imanaka, Naoko, Gainey, Maria D., Shrestha, Bimmi, Eitson, Jennifer L., Mar, Katrina B., Richardson, R. Blake, Ratushny, Alexander V., Litvak, Vladimir, Dabelic, Rea, Manicassamy, Balaji, Aitchison, John D., Aderem, Alan, Elliott, Richard M., García-Sastre, Adolfo, Racaniello, Vincent, Snijder, Eric J., Yokoyama, Wayne M., Diamond, Michael S., Virgin, Herbert W., Rice, Charles M.

“…The specificity of interferon effectors across an expanded range of viruses is studied, with results indicating that positive-sense single-stranded RNA viruses…”
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Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication by Oudshoorn, Diede, Rijs, Kevin, Limpens, Ronald W A L, Groen, Kevin, Koster, Abraham J, Snijder, Eric J, Kikkert, Marjolein, Bárcena, Montserrat

“…Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and…”
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Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture by te Velthuis, Aartjan J W, van den Worm, Sjoerd H E, Sims, Amy C, Baric, Ralph S, Snijder, Eric J, van Hemert, Martijn J

“…Increasing the intracellular Zn(2+) concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses,…”
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Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15 by ZHI SUN, YANHUA LI, RANSBURGH, Russell, SNIJDER, Eric J, YING FANG

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study by Schurink, Bernadette, Roos, Eva, Radonic, Teodora, Barbe, Ellis, Bouman, Catherine S C, de Boer, Hans H, de Bree, Godelieve J, Bulle, Esther B, Aronica, Eleonora M, Florquin, Sandrine, Fronczek, Judith, Heunks, Leo M A, de Jong, Menno D, Guo, Lihui, du Long, Romy, Lutter, Rene, Molenaar, Pam C G, Neefjes-Borst, E Andra, Niessen, Hans W M, van Noesel, Carel J M, Roelofs, Joris J T H, Snijder, Eric J, Soer, Eline C, Verheij, Joanne, Vlaar, Alexander P J, Vos, Wim, van der Wel, Nicole N, van der Wal, Allard C, van der Valk, Paul, Bugiani, Marianna

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not…”
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Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans by van Boheemen, Sander, de Graaf, Miranda, Lauber, Chris, Bestebroer, Theo M, Raj, V Stalin, Zaki, Ali Moh, Osterhaus, Albert D M E, Haagmans, Bart L, Gorbalenya, Alexander E, Snijder, Eric J, Fouchier, Ron A M

“…A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete…”
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Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae by Wolff, Georg, Limpens, Ronald W.A.L., Zheng, Shawn, Snijder, Eric J., Agard, David A., Koster, Abraham J., Bárcena, Montserrat

“…[Display omitted] •Micro-expansion joints greatly increase the cryo-FIB-milling success rate.•These lateral gaps milled in the support prevent cryo-lamellae…”
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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral by Delang, Leen, Segura Guerrero, Nidya, Tas, Ali, Quérat, Gilles, Pastorino, Boris, Froeyen, Mathy, Dallmeier, Kai, Jochmans, Dirk, Herdewijn, Piet, Bello, Felio, Snijder, Eric J, de Lamballerie, Xavier, Martina, Byron, Neyts, Johan, van Hemert, Martijn J, Leyssen, Pieter

“…T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This…”
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Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes by Bouvet, Mickaël, Lugari, Adrien, Posthuma, Clara C., Zevenhoven, Jessika C., Bernard, Stéphanie, Betzi, Stéphane, Imbert, Isabelle, Canard, Bruno, Guillemot, Jean-Claude, Lécine, Patrick, Pfefferle, Susanne, Drosten, Christian, Snijder, Eric J., Decroly, Etienne, Morelli, Xavier

“…The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1–16) encoded by…”
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Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein by Fang, Ying, Treffers, Emmely E, Li, Yanhua, Tas, Ali, Sun, Zhi, van der Meer, Yvonne, de Ru, Arnoud H, van Veelen, Peter A, Atkins, John F, Snijder, Eric J, Firth, Andrew E

“…Programmed −1 ribosomal frameshifting (−1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient…”
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