Search Results - "Snieckus, Victor"

A Practical in situ Generation of the Schwartz Reagent. Reduction of Tertiary Amides to Aldehydes and Hydrozirconation by Zhao, Yigang, Snieckus, Victor

“…A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method…”
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Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize by Johansson Seechurn, Carin C. C., Kitching, Matthew O., Colacot, Thomas J., Snieckus, Victor

“…In 2010, Richard Heck, Ei‐ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing…”
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Amide-Directed Ru-Catalyzed Hydrodemethoxylation of ortho‑Methoxy-Benzamides and -Naphthamides: A DoM Reaction Counterpart by Zhao, Yigang, Snieckus, Victor

“…A new ruthenium-catalyzed hydrodemethoxylation of ortho-methoxy-benzamides and -naphthamides involving amide-directed C–OMe bond activation and hydride…”
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Directed aromatic functionalization by Snieckus, Victor

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CH Activation by Amide Chelation Control: Ruthenium- Catalyzed Direct Synthesis of 2-Aryl-3-furanamides by Zhao, Yigang, Snieckus, Victor

“…A new, catalytic methodology for the synthesis of heterobiaryls by the ruthenium‐catalyzed CH activation/cross‐coupling of heterocyclic amides with aryl…”
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Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury by Wu, Danchen, Dasgupta, Asish, Chen, Kuang‐Hueih, Neuber‐Hess, Monica, Patel, Jignesh, Hurst, Timothy E., Mewburn, Jeffrey D., Lima, Patricia D. A., Alizadeh, Elahe, Martin, Ashley, Wells, Michael, Snieckus, Victor, Archer, Stephen L.

“…Mitochondrial fission is important in physiological processes, including coordination of mitochondrial and nuclear division during mitosis, and pathologic…”
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Suzuki−Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies by Quasdorf, Kyle W, Antoft-Finch, Aurora, Liu, Peng, Silberstein, Amanda L, Komaromi, Anna, Blackburn, Tom, Ramgren, Stephen D, Houk, K. N, Snieckus, Victor, Garg, Neil K

“…The first Suzuki−Miyaura cross-coupling reactions of the synthetically versatile aryl O-carbamate and O-sulfamate groups are described. The transformations…”
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Combined Directed Remote Metalation−Transition Metal Catalyzed Cross Coupling Strategies: The Total Synthesis of the Aglycones of the Gilvocarcins V, M, and E and Arnottin I by James, Clint A, Snieckus, Victor

“…A key directed remote metalation (DreM)−carbamoyl migration strategy was applied in an efficient synthesis of the naturally occurring…”
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Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics by Snieckus, Victor

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Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones by Hurst, Timothy E, Deichert, Julie A, Kapeniak, Lucas, Lee, Roland, Harris, Jesse, Jessop, Philip G, Snieckus, Victor

“…Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential…”
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Beyond Thermodynamic Acidity: A Perspective on the Complex-Induced Proximity Effect (CIPE) in Deprotonation Reactions by Whisler, Marna C., MacNeil, Stephen, Snieckus, Victor, Beak, Peter

“…The concept of the complex‐induced proximity effect (CIPE) in deprotonations is helpful in elucidating the mechanisms involved in carbanion chemistry and in…”
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Reductive Cleavage of Aryl O-Carbamates to Phenols by the Schwartz Reagent. Expedient Link to the Directed Ortho Metalation Strategy by Morin, Justin, Zhao, Yigang, Snieckus, Victor

“…A general, mild, and efficient method for the reductive cleavage of aryl O-carbamates to phenols, 1 → 2 using the Schwartz reagent is reported. The method is…”
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Copper-Catalyzed Cross-Coupling Interrupted by an Opportunistic Smiles Rearrangement: An Efficient Domino Approach to Dibenzoxazepinones by Kitching, Matthew O., Hurst, Timothy E., Snieckus, Victor

“…Unexpected Smiles! An unusual and highly regioselective synthesis of dibenzoxazepinones by a domino sequence assisted by an unexpected Smiles rearrangement is…”
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Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka ( Oryzias latipes) by Fallahtafti, Shirin, Rantanen, Toni, Brown, R. Stephen, Snieckus, Victor, Hodson, Peter V.

“…► Ring hydroxylation increased the toxicity of 1-methyl phenanthrene to Japanese medaka. ► The most toxic congeners were hydroxylated in the 7 and 8 positions…”
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Curriculum Vitae – Victor Algirdas Snieckus by Snieckus, Victor

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Quantitative structure–activity relationships for chronic toxicity of alkyl-chrysenes and alkyl-benz[a]anthracenes to Japanese medaka embryos (Oryzias latipes) by Lin, Hongkang, Morandi, Garrett D., Brown, R. Stephen, Snieckus, Victor, Rantanen, Toni, Jørgensen, Kåre B., Hodson, Peter V.

“…•Medaka embryos were exposed to alkyl chrysenes and benzo[a]anthracenes (BAA).•Concentrations were kept constant by partition controlled delivery.•Chrysene was…”
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Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis by Yam, Katherine C, D'Angelo, Igor, Kalscheuer, Rainer, Zhu, Haizhong, Wang, Jian-Xin, Snieckus, Victor, Ly, Lan H, Converse, Paul J, Jacobs, Jr, William R, Strynadka, Natalie, Eltis, Lindsay D

“…Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an…”
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In Situ Anionic Shielding for Regioselective Metalation: Directed peri and Iterative Metalation Routes to Polyfunctionalized 7-Azaindoles by Schneider, Cédric, David, Emilie, Toutov, Anton A., Snieckus, Victor

“…Strolling the ring: A general regioselective directed peri(C4)‐metalation route to 1 through an in situ N‐anionic protection of C2 is reported. The azaindoles…”
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Directed ortho Metalation-Based Methodology. Halo-, Nitroso-, and Boro-Induced ipso-Desilylation. Link to an in situ Suzuki Reaction by Zhao, Zhongdong, Snieckus, Victor

“…Treatment of DoM-derived silylated aromatics 2−4 under standard electrophilic halogenation conditions cleanly affords ipso-desilyation products 5−7, while…”
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Iridium-Catalyzed CH Activation versus Directed ortho Metalation: Complementary Borylation of Aromatics and Heteroaromatics by Hurst, Timothy E., Macklin, Todd K., Becker, Maike, Hartmann, Eduard, Kügel, Wolfgang, Parisienne-La Salle, Jean-Christophe, Batsanov, Andrei S., Marder, Todd B., Snieckus, Victor

“…Systematic studies are presented demonstrating the complementarity of directed ortho metalation (DoM) and Ir‐catalyzed strategies for the provision of…”
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