Search Results - "Sng, Julian D J"

Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes by Slonchak, Andrii, Hugo, Leon E., Freney, Morgan E., Hall-Mendelin, Sonja, Amarilla, Alberto A., Torres, Francisco J., Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Hall, Roy A., van den Hurk, Andrew F., Devine, Gregor J., Khromykh, Alexander A.

“…Flaviviruses, including Zika virus (ZIKV), utilise host mRNA degradation machinery to produce subgenomic flaviviral RNA (sfRNA). In mammalian hosts, this…”
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The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential by Peng, Nias Y G, Amarilla, Alberto A, Hugo, Leon E, Modhiran, Naphak, Sng, Julian D J, Slonchak, Andrii, Watterson, Daniel, Setoh, Yin Xiang, Khromykh, Alexander A

“…During 2015-2016, outbreaks of Zika virus (ZIKV) occurred in Southeast Asia and the Americas. Most ZIKV infections in humans are asymptomatic, while clinical…”
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Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution by Slonchak, Andrii, Parry, Rhys, Pullinger, Brody, Sng, Julian D. J., Wang, Xiaohui, Buck, Teresa F., Torres, Francisco J., Harrison, Jessica J., Colmant, Agathe M. G., Hobson-Peters, Jody, Hall, Roy A., Tuplin, Andrew, Khromykh, Alexander A.

“…Subgenomic flaviviral RNAs (sfRNAs) are virus-derived noncoding RNAs produced by pathogenic mosquito-borne flaviviruses (MBF) to counteract the host antiviral…”
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In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting by Tu, Wen Juan, Melino, Michelle, Dunn, Jenny, McCuaig, Robert D., Bielefeldt-Ohmann, Helle, Tsimbalyuk, Sofiya, Forwood, Jade K., Ahuja, Taniya, Vandermeide, John, Tan, Xiao, Tran, Minh, Nguyen, Quan, Zhang, Liang, Nam, Andy, Pan, Liuliu, Liang, Yan, Smith, Corey, Lineburg, Katie, Nguyen, Tam H., Sng, Julian D. J., Tong, Zhen Wei Marcus, Chew, Keng Yih, Short, Kirsty R., Le Grand, Roger, Seddiki, Nabila, Rao, Sudha

“…In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected…”
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Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2 by Peng, Nias Y G, Sng, Julian D J, Setoh, Yin Xiang, Khromykh, Alexander A

“…The identification of four potential nonstructural 5 (NS5) residues-K28, K45, V335, and S749-that share the same amino acid preference in STAT2-interacting…”
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An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2 by Amarilla, Alberto A, Modhiran, Naphak, Setoh, Yin Xiang, Peng, Nias Y G, Sng, Julian D J, Liang, Benjamin, McMillan, Christopher L D, Freney, Morgan E, Cheung, Stacey T M, Chappell, Keith J, Khromykh, Alexander A, Young, Paul R, Watterson, Daniel

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as the causative agent of coronavirus disease 2019 and is capable of…”
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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology by Aguado, Julio, Amarilla, Alberto A, Taherian Fard, Atefeh, Albornoz, Eduardo A, Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K, Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A, Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E, Parry, Rhys, Sng, Julian D J, Isaacs, Ariel, Khromykh, Alexander A, Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P, Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N, Woodruff, Trent M, Mar, Jessica C, Watterson, Daniel, Wolvetang, Ernst J

“…Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent…”
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Monoclonal Antibodies Specific for SARS-CoV-2 Spike Protein Suitable for Multiple Applications for Current Variants of Concern by Morgan, Mahali S, Yan, Kexin, Le, Thuy T, Johnston, Ryan A, Amarilla, Alberto A, Muller, David A, McMillan, Christopher L D, Modhiran, Naphak, Watterson, Daniel, Potter, James R, Sng, Julian D J, Lor, Mary, Paramitha, Devina, Isaacs, Ariel, Khromykh, Alexander A, Hall, Roy A, Suhrbier, Andreas, Rawle, Daniel J, Hobson-Peters, Jody

“…The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spawned an ongoing…”
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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein by Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J., Khromykh, Alexander A., Chappell, Keith J., Watterson, Daniel, Woodruff, Trent M.

“…Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also…”
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A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses by Amarilla, Alberto A., Sng, Julian D. J., Parry, Rhys, Deerain, Joshua M., Potter, James R., Setoh, Yin Xiang, Rawle, Daniel J., Le, Thuy T., Modhiran, Naphak, Wang, Xiaohui, Peng, Nias Y. G., Torres, Francisco J., Pyke, Alyssa, Harrison, Jessica J., Freney, Morgan E., Liang, Benjamin, McMillan, Christopher L. D., Cheung, Stacey T. M., Guevara, Darwin J. Da Costa, Hardy, Joshua M., Bettington, Mark, Muller, David A., Coulibaly, Fasséli, Moore, Frederick, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Hobson-Peters, Jody, Suhrbier, Andreas, Watterson, Daniel, Khromykh, Alexander A.

“…The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the…”
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High-Throughput Synthesis and Evaluation of Antiviral Copolymers for Enveloped Respiratory Viruses by Mengist, Hylemariam Mihiretie, Denman, Paul, Frost, Charlotte, Sng, Julian D.J., Logan, Saskia, Yarlagadda, Tejasri, Spann, Kirsten M., Barner, Leonie, Fairfull-Smith, Kathryn E, Short, Kirsty R., Boase, Nathan RB

“…COVID-19 made apparent the devastating impact viral pandemics have had on global health and order. Development of broad-spectrum antivirals to provide early…”
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Elevated BMI reduces the humoral response to SARS‐CoV‐2 infection by Tong, Marcus ZW, Sng, Julian DJ, Carney, Meagan, Cooper, Lucy, Brown, Samuel, Lineburg, Katie E, Chew, Keng Yih, Collins, Neve, Ignacio, Kirsten, Airey, Megan, Burr, Lucy, Joyce, Briony A, Jayasinghe, Dhilshan, McMillan, Christopher LD, Muller, David A, Adhikari, Anurag, Gallo, Linda A, Dorey, Emily S, Barrett, Helen L, Gras, Stephanie, Smith, Corey, Good‐Jacobson, Kim, Short, Kirsty R

“…ABSTRACT Objective Class III obesity (body mass index [BMI] ≥ 40 kg m−2) significantly impairs the immune response to SARS‐CoV‐2 vaccination. However, the…”
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Assessing the potential of unmanned aerial vehicle spraying of aqueous ozone as an outdoor disinfectant for SARS-CoV-2 by Albert, Simon, Amarilla, Alberto A., Trollope, Ben, Sng, Julian D.J., Setoh, Yin Xiang, Deering, Nathaniel, Modhiran, Naphak, Weng, Sung-Hsia, Melo, Maria C., Hutley, Nicholas, Nandy, Avik, Furlong, Michael J., Young, Paul R., Watterson, Daniel, Grinham, Alistair R., Khromykh, Alexander A.

“…The COVID-19 pandemic has revealed gaps in our understanding of safe, effective and efficient means of disinfecting high use public spaces. Whilst this creates…”
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Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells by Zhu, Yanshan, Chew, Keng Yih, Wu, Melanie, Karawita, Anjana C, McCallum, Georgina, Steele, Lauren E, Yamamoto, Ayaho, Labzin, Larisa I, Yarlagadda, Tejasri, Khromykh, Alexander A, Wang, Xiaohui, Sng, Julian D J, Stocks, Claudia J, Xia, Yao, Kollmann, Tobias R, Martino, David, Joensuu, Merja, Meunier, Frédéric A, Balistreri, Giuseppe, Bielefeldt-Ohmann, Helle, Bowen, Asha C, Kicic, Anthony, Sly, Peter D, Spann, Kirsten M, Short, Kirsty R

“…Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that…”
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Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2 by Shaker, Mohammed R, Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D, Sng, Julian D J, Cooper-White, Justin, Khromykh, Alexander A, Wolvetang, Ernst J

“…Why individuals with Down syndrome (DS) are more susceptible to SARS-CoV-2-induced neuropathology remains elusive. Choroid plexus (ChP) plays critical roles in…”
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Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis by Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D J, Chaggar, Harman, Freney, Morgan E, Yan, Kexin, Torres, Francisco J, Amarilla, Alberto A, Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas, Khromykh, Alexander A

“…All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the…”
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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV‑2 by Disrupting the Spike–ACE2 Interaction by Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung, Laidlaw, Stephen, Hammond, Edward, Dredge, Keith, Wilkinson, Tom M. A., Watterson, Daniel, Khromykh, Alexander A., Suhrbier, Andreas, Carroll, Miles W., Trybala, Edward, Bergström, Tomas, Ferro, Vito, Skidmore, Mark A., Turnbull, Jeremy E.

“…Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus,…”
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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants by Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D.J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian, Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L., Young, Paul R., Chappell, Keith, Bailey, Dalan, Kjaer, Andreas, Herth, Matthias Manfred, Jurado, Kellie Ann, Schwefel, David, Rojas-Fernandez, Alejandro, Watterson, Daniel

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Omicron variant sub-lineages spread rapidly worldwide, mostly due to their immune-evasive…”
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