Search Results - "Snedeker, Jess"

Tendon injury and repair – A perspective on the basic mechanisms of tendon disease and future clinical therapy by Snedeker, Jess G., Foolen, Jasper

“…[Display omitted] Tendon is an intricately organized connective tissue that efficiently transfers muscle force to the bony skeleton. Its structure, function,…”
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Tendon tissue microdamage and the limits of intrinsic repair by Stauber, Tino, Blache, Ulrich, Snedeker, Jess G.

“…The transmission of mechanical muscle force to bone for musculoskeletal stability and movement is one of the most important functions of tendon. The…”
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The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly by Snedeker, Jess G, Gautieri, Alfonso

“…The non-enzymatic reaction of proteins with glucose (glycation) is a topic of rapidly growing importance in human health and medicine. There is increasing…”
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Advanced glycation end-products reduce collagen molecular sliding to affect collagen fibril damage mechanisms but not stiffness by Fessel, Gion, Li, Yufei, Diederich, Vincent, Guizar-Sicairos, Manuel, Schneider, Philipp, Sell, David R, Monnier, Vincent M, Snedeker, Jess G

“…Advanced glycation end-products (AGE) contribute to age-related connective tissue damage and functional deficit. The documented association between AGE…”
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Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue by Gautieri, Alfonso, Passini, Fabian S., Silván, Unai, Guizar-Sicairos, Manuel, Carimati, Giulia, Volpi, Piero, Moretti, Matteo, Schoenhuber, Herbert, Redaelli, Alberto, Berli, Martin, Snedeker, Jess G.

“…Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation…”
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Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo by Schoenenberger, Angelina D., Tempfer, Herbert, Lehner, Christine, Egloff, Jasmin, Mauracher, Marita, Bird, Anna, Widmer, Jonas, Maniura-Weber, Katharina, Fucentese, Sandro F., Traweger, Andreas, Silvan, Unai, Snedeker, Jess G.

“…Appropriate macrophage response to an implanted biomaterial is crucial for successful tissue healing outcomes. In this work we investigated how intrinsic…”
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Supraspinatus tendon load during abduction is dependent on the size of the critical shoulder angle: A biomechanical analysis by Gerber, Christian, Snedeker, Jess G., Baumgartner, Daniel, Viehöfer, Arnd F.

“…ABSTRACT Shoulders with supraspinatus (SSP) tears are associated with significantly larger critical shoulder angles (CSA) compared to disease‐free shoulders…”
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Substrate fiber alignment mediates tendon cell response to inflammatory signaling by Schoenenberger, Angelina D., Foolen, Jasper, Moor, Pascal, Silvan, Unai, Snedeker, Jess G.

“…[Display omitted] Healthy tendon tissue features a highly aligned extracellular matrix that becomes disorganized with disease. Recent evidence suggests that…”
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Advanced glycation end-products diminish tendon collagen fiber sliding by Li, Yufei, Fessel, Gion, Georgiadis, Marios, Snedeker, Jess G.

“…Connective tissue aging and diabetes related comorbidity are associated with compromised tissue function, increased susceptibility to injury, and reduced…”
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Pelvic incidence–lumbar lordosis mismatch results in increased segmental joint loads in the unfused and fused lumbar spine by Senteler, Marco, Weisse, Bernhard, Snedeker, Jess G., Rothenfluh, Dominique A.

“…Purpose Symptomatic adjacent segment disease (ASD) has been reported to occur in up to 27 % of lumbar fusion patients. A previous study identified patients at…”
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Tissue alignment enhances remodeling potential of tendon-derived cells - Lessons from a novel microtissue model of tendon scarring by Foolen, Jasper, Wunderli, Stefania L., Loerakker, Sandra, Snedeker, Jess G.

“…Tendinopathy is a widespread and unresolved clinical challenge, in which associated pain and hampered mobility present a major cause for work-related…”
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Biomechanical contribution of spinal structures to stability of the lumbar spine—novel biomechanical insights by Widmer, Jonas, Cornaz, Frédéric, Scheibler, Gita, Spirig, José Miguel, Snedeker, Jess G., Farshad, Mazda

“…The contribution of anatomical structures to the stability of the spine is of great relevance for diagnostic, prognostic and therapeutic evaluation of spinal…”
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Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes by Sharma, Ram I, Snedeker, Jess G

“…We investigated substrate dependent paracrine signaling between subpopulations of bone marrow stromal cells (BMSCs) that may affect the formation, or perhaps…”
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Assessing the effects of intratendinous genipin injections: Mechanical augmentation and spatial distribution in an ex vivo degenerative tendon model by Tondelli, Timo, Götschi, Tobias, Camenzind, Roland S, Snedeker, Jess G

“…Tendinopathy is a common musculoskeletal disorder and current treatment options show limited success. Genipin is an effective collagen crosslinker with low…”
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Dose- and time-dependent effects of genipin crosslinking on cell viability and tissue mechanics – Toward clinical application for tendon repair by Fessel, Gion, Cadby, Jennifer, Wunderli, Stefania, van Weeren, René, Snedeker, Jess G.

“…The crosslinking agent genipin is increasingly invoked for the mechanical augmentation of collagen tissues and implants, and has previously been demonstrated…”
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Investigation of the relationship between tensile viscoelasticity and unloaded ultrasound shear wave measurements in ex vivo tendon by Götschi, Tobias, Schärer, Yannick, Gennisson, Jean-Luc, Snedeker, Jess G.

“…Mechanical properties of biological tissues are of key importance for proper function and in situ methods for mechanical characterization are sought after in…”
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Biomaterial surface energy-driven ligand assembly strongly regulates stem cell mechanosensitivity and fate on very soft substrates by Razafiarison, Tojo, Holenstein, Claude N., Stauber, Tino, Jovic, Milan, Vertudes, Edward, Loparic, Marko, Kawecki, Maciej, Bernard, Laetitia, Silvan, Unai, Snedeker, Jess G.

“…Although mechanisms of cell–material interaction and cellular mechanotransduction are increasingly understood, the mechanical insensitivity of mesenchymal…”
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Evidence against proteoglycan mediated collagen fibril load transmission and dynamic viscoelasticity in tendon by Fessel, Gion, Snedeker, Jess G.

“…The glycosaminoglycan (GAG) dermatan sulfate and chondroitin sulfate side-chains of small leucine-rich proteoglycans have been increasingly posited to act as…”
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Pedicle screw navigation using surface digitization on the Microsoft HoloLens by Liebmann, Florentin, Roner, Simon, von Atzigen, Marco, Scaramuzza, Davide, Sutter, Reto, Snedeker, Jess, Farshad, Mazda, Fürnstahl, Philipp

“…Purpose In spinal fusion surgery, imprecise placement of pedicle screws can result in poor surgical outcome or may seriously harm a patient. Patient-specific…”
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The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal Cells by Hussien, Amro A., Niederoest, Barbara, Bollhalder, Maja, Goedecke, Nils, Snedeker, Jess G.

“…Extracellular matrix stiffness is a major regulator of cellular states. Stiffness‐sensing investigations are typically performed using cells that have acquired…”
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