Search Results - "Sneddon, Julie B."

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges by Sneddon, Julie B., Tang, Qizhi, Stock, Peter, Bluestone, Jeffrey A., Roy, Shuvo, Desai, Tejal, Hebrok, Matthias

“…Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet…”
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A single-cell atlas and lineage analysis of the adult Drosophila ovary by Rust, Katja, Byrnes, Lauren E., Yu, Kevin Shengyang, Park, Jason S., Sneddon, Julie B., Tward, Aaron D., Nystul, Todd G.

“…The Drosophila ovary is a widely used model for germ cell and somatic tissue biology. Here we use single-cell RNA-sequencing (scRNA-seq) to build a…”
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Lineage dynamics of murine pancreatic development at single-cell resolution by Byrnes, Lauren E., Wong, Daniel M., Subramaniam, Meena, Meyer, Nathaniel P., Gilchrist, Caroline L., Knox, Sarah M., Tward, Aaron D., Ye, Chun J., Sneddon, Julie B.

“…Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time. Here, we…”
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla by Bautista, Jhoanne L., Cramer, Nathan T., Miller, Corey N., Chavez, Jessica, Berrios, David I., Byrnes, Lauren E., Germino, Joe, Ntranos, Vasilis, Sneddon, Julie B., Burt, Trevor D., Gardner, James M., Ye, Chun J., Anderson, Mark S., Parent, Audrey V.

“…The thymus’ key function in the immune system is to provide the necessary environment for the development of diverse and self-tolerant T lymphocytes. While…”
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Location, location, location: the cancer stem cell niche by Sneddon, Julie B, Werb, Zena

“…The existence of a stem cell niche, or physiological microenvironment, consisting of specialized cells that directly and indirectly participate in stem cell…”
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Author Correction: A single-cell atlas and lineage analysis of the adult Drosophila ovary by Rust, Katja, Byrnes, Lauren E., Yu, Kevin Shengyang, Park, Jason S., Sneddon, Julie B., Tward, Aaron D., Nystul, Todd G.

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Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs by de la O, Sean, Yao, Xinkai, Chang, Sean, Liu, Zhe, Sneddon, Julie B.

“…Numerous studies have characterized the existence of cell subtypes, along with their corresponding transcriptional profiles, within the developing mouse…”
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Robustness, Scalability, and Integration of a Wound-Response Gene Expression Signature in Predicting Breast Cancer Survival by Chang, Howard Y., Dimitry S. A. Nuyten, Sneddon, Julie B., Hastie, Trevor, Tibshirani, Robert, Sørlie, Therese, Dai, Hongyue, He, Yudong D., Laura J. van't Veer, Bartelink, Harry, van de Rijn, Matt, Brown, Patrick O., van de Vijver, Marc J.

“…Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously…”
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Bone Morphogenetic Protein Antagonist Gremlin 1 Is Widely Expressed by Cancer-Associated Stromal Cells and Can Promote Tumor Cell Proliferation by Sneddon, Julie B., Zhen, Hanson H., Montgomery, Kelli, van de Rijn, Matt, Tward, Aaron D., West, Robert, Gladstone, Hayes, Chang, Howard Y., Morganroth, Greg S., Oro, Anthony E., Brown, Patrick O.

“…Although tissue microenvironments play critical roles in epithelial development and tumorigenesis, the factors mediating these effects are poorly understood…”
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Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds by Chang, Howard Y, Sneddon, Julie B, Alizadeh, Ash A, Sood, Ruchira, West, Rob B, Montgomery, Kelli, Chi, Jen-Tsan, van de Rijn, Matt, Botstein, David, Brown, Patrick O

“…Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound…”
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Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme by SNEDDON, Julie B, BOROWIAK, Malgorzata, MELTON, Douglas A

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Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space by Chendke, Gauree S., Kharbikar, Bhushan N., Ashe, Sudipta, Faleo, Gaetano, Sneddon, Julie B., Tang, Qizhi, Hebrok, Matthias, Desai, Tejal A.

“…Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves blood glucose regulation by replenishing the endogenous beta cells…”
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macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans by Welm, Alana L, Sneddon, Julie B, Taylor, Carmen, Nuyten, Dimitry S.A, van de Vijver, Marc J, Hasegawa, Bruce H, Bishop, J. Michael

“…A better understanding of tumor metastasis requires development of animal models that authentically reproduce the metastatic process. By modifying an existing…”
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Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia by Patzek, Sophie, Liu, Zhe, de la O, Sean, Chang, Sean, Byrnes, Lauren E., Zhang, Xiuqin, Ornitz, David M., Sneddon, Julie B.

“…Pancreatic development requires spatially and temporally controlled expression of growth factors derived from mesenchyme. Here, we report that in mice the…”
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Predicting a local recurrence after breast-conserving therapy by gene expression profiling by Nuyten, Dimitry S A, Kreike, Bas, Hart, Augustinus A M, Chi, Jen-Tsan Ashley, Sneddon, Julie B, Wessels, Lodewyk F A, Peterse, Hans J, Bartelink, Harry, Brown, Patrick O, Chang, Howard Y, van de Vijver, Marc J

“…To tailor local treatment in breast cancer patients there is a need for predicting ipsilateral recurrences after breast-conserving therapy. After adequate…”
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Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective by Migliorini, Adriana, Nostro, Maria Cristina, Sneddon, Julie B

“…Tremendous progress has been made over the last two decades in the field of pancreatic beta cell replacement therapy as a curative measure for diabetes…”
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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes by Cheng, Chia-Wei, Villani, Valentina, Buono, Roberta, Wei, Min, Kumar, Sanjeev, Yilmaz, Omer H., Cohen, Pinchas, Sneddon, Julie B., Perin, Laura, Longo, Valter D.

“…Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to…”
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Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme by Sneddon, Julie B., Borowiak, Malgorzata, Melton, Douglas A.

“…The pancreatic lineage is used as a model for embryonic-stem-cell differentiation, and shows that co-culture with organ-matched mesenchyme permits…”
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Pancreatic development: one cell at a (pseudo)time by Liu, Zhe, Sneddon, Julie B

“…Gaining a comprehensive understanding of the principles guiding lineage differentiation during organogenesis is a challenge. In this issue, Yu et al ( 2019 )…”
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Beta Living through Alpha Cells by Patzek, Sophie, Sneddon, Julie B.

“…Recently in Nature, Furuyama et al. (2019) provide evidence for lineage plasticity in the human endocrine pancreas, demonstrating that α cells derived from…”
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