Search Results - "Snavely, R."

High-throughput functional comparison of promoter and enhancer activities by Nguyen, Thomas A, Jones, Richard D, Snavely, Andrew R, Pfenning, Andreas R, Kirchner, Rory, Hemberg, Martin, Gray, Jesse M

“…Promoters initiate RNA synthesis, and enhancers stimulate promoter activity. Whether promoter and enhancer activities are encoded distinctly in DNA sequences…”
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Fast ignition by intense laser-accelerated proton beams by Roth, M, Cowan, T E, Key, M H, Hatchett, S P, Brown, C, Fountain, W, Johnson, J, Pennington, D M, Snavely, R A, Wilks, S C, Yasuike, K, Ruhl, H, Pegoraro, F, Bulanov, S V, Campbell, E M, Perry, M D, Powell, H

“…The concept of fast ignition with inertial confinement fusion (ICF) is a way to reduce the energy required for ignition and burn and to maximize the gain…”
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Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion by Snavely, Andrew R, Heo, Keungjung, Petrova, Veselina, Ho, Tammy Szu-Yu, Huang, Xuan, Hermawan, Crystal, Kagan, Ruth, Deng, Tao, Singeç, Ilyas, Chen, Long, Barret, Lee B, Woolf, Clifford J

“…The proteosome inhibitor bortezomib has revolutionized the treatment of multiple hematologic malignancies, but in many cases, its efficacy is limited by a…”
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Enhancement of proton acceleration by hot-electron recirculation in thin foils irradiated by ultraintense laser pulses by Mackinnon, A J, Sentoku, Y, Patel, P K, Price, D W, Hatchett, S, Key, M H, Andersen, C, Snavely, R, Freeman, R R

“…MeV-proton production from solid targets irradiated by 100-fs laser pulses at intensities above 1x10(20) W cm(-2) has been studied as a function of initial…”
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Plasma devices to guide and collimate a high density of MeV electrons by Kodama, R, Sentoku, Y, Chen, Z. L, Kumar, G. R, Hatchett, S. P, Toyama, Y, Cowan, T. E, Freeman, R. R, Fuchs, J, Izawa, Y, Key, M. H, Kitagawa, Y, Kondo, K, Matsuoka, T, Nakamura, H, Nakatsutsumi, M, Norreys, P. A, Norimatsu, T, Snavely, R. A, Stephens, R. B, Tampo, M, Tanaka, K. A, Yabuuchi, T

“…The development of ultra-intense lasers has facilitated new studies in laboratory astrophysics and high-density nuclear science, including laser fusion. Such…”
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Intense high-energy proton beams from Petawatt-laser irradiation of solids by Snavely, R A, Key, M H, Hatchett, S P, Cowan, T E, Roth, M, Phillips, T W, Stoyer, M A, Henry, E A, Sangster, T C, Singh, M S, Wilks, S C, MacKinnon, A, Offenberger, A, Pennington, D M, Yasuike, K, Langdon, A B, Lasinski, B F, Johnson, J, Perry, M D, Campbell, E M

“…An intense collimated beam of high-energy protons is emitted normal to the rear surface of thin solid targets irradiated at 1 PW power and peak intensity…”
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Proton radiography of a laser-driven implosion by Mackinnon, A J, Patel, P K, Borghesi, M, Clarke, R C, Freeman, R R, Habara, H, Hatchett, S P, Hey, D, Hicks, D G, Kar, S, Key, M H, King, J A, Lancaster, K, Neely, D, Nikkro, A, Norreys, P A, Notley, M M, Phillips, T W, Romagnani, L, Snavely, R A, Stephens, R B, Town, R P J

“…Protons accelerated by a picosecond laser pulse have been used to radiograph a 500 microm diameter capsule, imploded with 300 J of laser light in 6…”
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Effect of plasma scale length on multi-MeV proton production by intense laser pulses by Mackinnon, A J, Borghesi, M, Hatchett, S, Key, M H, Patel, P K, Campbell, H, Schiavi, A, Snavely, R, Wilks, S C, Willi, O

“…The influence of the plasma density scale length on the production of MeV protons from thin foil targets irradiated at I lambda(2) = 5 x 10(19) W cm(-2) has…”
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Photonuclear fission from high energy electrons from ultraintense laser-solid interactions by Cowan, TE, Hunt, AW, Phillips, TW, Wilks, SC, Perry, MD, Brown, C, Fountain, W, Hatchett, S, Johnson, J, Key, MH, Parnell, T, Pennington, DM, Snavely, RA, Takahashi, Y

“…A new regime of laser-matter interactions in which the quiver motion of plasma electrons is fully relativistic, with energies extending well above the…”
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Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons by Petrova, Veselina, Snavely, Andrew R., Splaine, Jennifer, Zhen, Shannon, Singh, Bhagat, Pandey, Roshan, Chen, Kuchuan, Cheng, Anya, Hermawan, Crystal, Barrett, Lee B., Smith, Jennifer A., Woolf, Clifford J.

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cancer chemotherapy that can often limit treatment options for cancer patients…”
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Experimental Characterization of a Strongly Coupled Solid Density Plasma Generated in a Short-pulse Laser Target Interaction by Gregori, G., Hansen, S. B., Clarke, R., Heathcote, R., Key, M. H., King, J., Klein, R. I., Izumi, N., Mackinnon, A. J., Moon, S. J., Park, H.-S., Pasley, J., Patel, N., Patel, P. K., Remington, B. A., Ryutov, D. D., Shepherd, R., Snavely, R. A., Wilks, S. C., Zhang, B. B., Glenzer, S. H.

“…We have measured high resolution copper Kα spectra from a picosecond high intensity laser produced plasma. By fitting the shape of the experimental spectra…”
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Intense electron and proton beams from PetaWatt laser–matter interactions by Cowan, T.E., Roth, M., Johnson, J., Brown, C., Christl, M., Fountain, W., Hatchett, S., Henry, E.A., Hunt, A.W., Key, M.H., MacKinnon, A., Parnell, T., Pennington, D.M., Perry, M.D., Phillips, T.W., Sangster, T.C., Singh, M., Snavely, R., Stoyer, M., Takahashi, Y., Wilks, S.C., Yasuike, K.

“…Recent experiments at the LLNL Petawatt Laser have demonstrated the generation of intense, high-energy beams of electrons and ions from the interaction of…”
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Petawatt laser system and experiments by Pennington, D.M., Brown, C.G., Cowan, T.E., Hatchett, S.P., Henry, E., Herman, S., Kartz, M., Key, M., Koch, J., MacKinnon, A.J., Perry, M.D., Phillips, T.W., Roth, M., Sangster, T.C., Singh, M., Snavely, R.A., Stoyer, M., Stuart, B.C., Wilks, S.C.

“…We have developed a hybrid Ti:sapphire-Nd:glass laser system that produces more than 1.5 PW of peak power. The system has produced up to 680 J of energy on…”
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Understanding the role of fast electrons in the heating of dense matter: experimental techniques and recent results by Freeman, R., Anderson, C., Hill, J.M., King, J., Snavely, R., Hatchett, S., Key, M., Koch, J., MacKinnon, A., Stephens, R., Cowan, T.

“…An intense laser impinging upon dense matter converts a large fraction of its energy into fast electrons. (Here we take “fast” to mean electrons that are much…”
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The neurotoxicity of antibacterial agents by Snavely, S R, Hodges, G R

“…Commonly used antibacterial agents may be associated with various neurotoxic reactions. Central nervous system toxicities include seizure disorders,…”
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Fast-electron transport and heating of solid targets in high-intensity laser interactions measured by K alpha fluorescence by Martinolli, E, Koenig, M, Baton, S D, Santos, J J, Amiranoff, F, Batani, D, Perelli-Cippo, E, Scianitti, F, Gremillet, L, Mélizzi, R, Decoster, A, Rousseaux, C, Hall, T A, Key, M H, Snavely, R, MacKinnon, A J, Freeman, R R, King, J A, Stephens, R, Neely, D, Clarke, R J

“…We present experimental results on fast-electron energy deposition into solid targets in ultrahigh intensity laser-matter interaction. X-ray K alpha emission…”
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Relativistic laser channeling in plasmas for fast ignition by Lei, A L, Pukhov, A, Kodama, R, Yabuuchi, T, Adumi, K, Endo, K, Freeman, R R, Habara, H, Kitagawa, Y, Kondo, K, Kumar, G R, Matsuoka, T, Mima, K, Nagatomo, H, Norimatsu, T, Shorokhov, O, Snavely, R, Yang, X Q, Zheng, J, Tanaka, K A

“…We report an experimental observation suggesting plasma channel formation by focusing a relativistic laser pulse into a long-scale-length preformed plasma. The…”
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Ion acceleration from the shock front induced by hole boring in ultraintense laser-plasma interactions by Habara, H, Lancaster, K L, Karsch, S, Murphy, C D, Norreys, P A, Evans, R G, Borghesi, M, Romagnani, L, Zepf, M, Norimatsu, T, Toyama, Y, Kodama, R, King, J A, Snavely, R, Akli, K, Zhang, B, Freeman, R, Hatchett, S, MacKinnon, A J, Patel, P, Key, M H, Stoeckl, C, Stephens, R B, Fonseca, R A, Silva, L O

“…Ion-acceleration processes have been studied in ultraintense laser plasma interactions for normal incidence irradiation of solid deuterated targets via neutron…”
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Simulations of electron transport for fast ignition using LSP by Town, R.P.J., Chen, C., Cottrill, L.A., Key, M.H., Kruer, W.L., Langdon, A.B., Lasinski, B.F., Snavely, R.A., Still, C.H., Tabak, M., Welch, D.R., Wilks, S.C.

“…A crucial issue for the viability of the fast ignition approach to inertial fusion energy is the transport of the ignition pulse energy from the critical…”
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K α fluorescence measurement of relativistic electron transport in the context of fast ignition by Stephens, R. B., Snavely, R. A., Aglitskiy, Y., Amiranoff, F., Andersen, C., Batani, D., Baton, S. D., Cowan, T., Freeman, R. R., Hall, T., Hatchett, S. P., Hill, J. M., Key, M. H., King, J. A., Koch, J. A., Koenig, M., MacKinnon, A. J., Lancaster, K. L., Martinolli, E., Norreys, P., Perelli-Cippo, E., Rabec Le Gloahec, M., Rousseaux, C., Santos, J. J., Scianitti, F.

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