Search Results - "Snapp, Erik L."

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress by Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.

“…Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER…”
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ERdj3 regulates BiP occupancy in living cells by Guo, Feng, Snapp, Erik L

“…Co-chaperones regulate chaperone activities and are likely to impact a protein-folding environment as much as the chaperone itself. As co-chaperones are…”
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Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin by Lajoie, Patrick, Snapp, Erik L

“…Huntington's disease (HD) is caused by expanded glutamine repeats within the huntingtin (Htt) protein. Mutant Htt (mHtt) in the cytoplasm has been linked to…”
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An in vitro compartmentalization-based method for the selection of bond-forming enzymes from large libraries by Gianella, Paul, Snapp, Erik L., Levy, Matthew

“…ABSTRACT We have developed a generalized in vitro compartmentalization‐based bead display selection strategy that allows for the identification of enzymes that…”
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Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape by Chorro, Laurent, Suzuki, Masako, Chin, Shu Shien, Williams, Tere M., Snapp, Erik L., Odagiu, Livia, Labrecque, Nathalie, Lauvau, Grégoire

“…Foxp3 + CD4 + regulatory T (T reg ) cells are essential for preventing fatal autoimmunity and safeguard immune homeostasis in vivo. While expression of the…”
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Evolutionarily Conserved Gene Family Important for Fat Storage by Kadereit, Bert, Kumar, Pradeep, Wang, Wen-Jun, Miranda, Diego, Snapp, Erik L., Severina, Nadia, Torregroza, Ingrid, Evans, Todd, Silver, David L.

“…The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from Saccharomyces cerevisiae to humans. Although much is known…”
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Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells by Lajoie, Patrick, Moir, Robyn D, Willis, Ian M, Snapp, Erik L

“…Accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) stress pathway. To enhance…”
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Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat by Kung, Leslie F, Pagant, Silvere, Futai, Eugene, D'Arcangelo, Jennifer G, Buchanan, Roy, Dittmar, John C, Reid, Robert J D, Rothstein, Rodney, Hamamoto, Susan, Snapp, Erik L, Schekman, Randy, Miller, Elizabeth A

“…Vesicle budding from the endoplasmic reticulum (ER) employs a cycle of GTP binding and hydrolysis to regulate assembly of the COPII coat. We have identified a…”
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Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response by Shen, Jingshi, Snapp, Erik L., Lippincott-Schwartz, Jennifer, Prywes, Ron

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Traffic of p24 Proteins and COPII Coat Composition Mutually Influence Membrane Scaffolding by D’Arcangelo, Jennifer G., Crissman, Jonathan, Pagant, Silvere, Čopič, Alenka, Latham, Catherine F., Snapp, Erik L., Miller, Elizabeth A.

“…Eukaryotic protein secretion requires efficient and accurate delivery of diverse secretory and membrane proteins. This process initiates in the ER, where…”
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Formation of Stacked ER Cisternae by Low Affinity Protein Interactions by Snapp, Erik L., Hedge, Ramanujan S., Francolini, Maura, Lombardo, Francesca, Colombo, Sara, Pedrazzini, Emanuela, Borgese, Nica, Lippincott-Schwartz, Jennifer

“…The endoplasmic reticulum (ER) can transform from a network of branching tubules into stacked membrane arrays (termed organized smooth ER [OSER]) in response…”
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essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells by Ostrovsky, Olga, Makarewich, Catherine A, Snapp, Erik L, Argon, Yair

“…Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER) chaperone for which only few client proteins and no cofactors are known and whose mode of…”
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Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans by Müller, Linda, de Escauriaza, Maria Diaz, Lajoie, Patrick, Theis, Melanie, Jung, Martin, Müller, Anika, Burgard, Carsten, Greiner, Markus, Snapp, Erik L, Dudek, Johanna, Zimmermann, Richard

“…Because of similarity to their yeast orthologues, the two membrane proteins of the human endoplasmic reticulum (ER) Sec62 and Sec63 are expected to play a role…”
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Endoplasmic Reticulum Export Sites and Golgi Bodies Behave as Single Mobile Secretory Units in Plant Cells by Luis L. P. da Silva, Snapp, Erik L., Denecke, Jürgen, Lippincott-Schwartz, Jennifer, Hawes, Chris, Brandizzi, Federica

“…In contrast with animals, plant cells contain multiple mobile Golgi stacks distributed over the entire cytoplasm. However, the distribution and dynamics of…”
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Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum by Vander Heyden, Abigail B, Naismith, Teresa V, Snapp, Erik L, Hanson, Phyllis I

“…TorsinA is a membrane‐associated enzyme in the endoplasmic reticulum (ER) lumen that is mutated in DYT1 dystonia. How it remains in the ER has been unclear. We…”
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Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2 by Gross, David A, Snapp, Erik L, Silver, David L

“…Fat storage-Inducing Transmembrane proteins 1 & 2 (FIT1/FITM1 and FIT2/FITM2) belong to a unique family of evolutionarily conserved proteins localized to the…”
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Alcohol Disrupts Endoplasmic Reticulum Function and Protein Secretion in Hepatocytes by Howarth, Deanna L., Vacaru, Ana M., Tsedensodnom, Orkhontuya, Mormone, Elisabetta, Nieto, Natalia, Costantini, Lindsey M., Snapp, Erik L., Sadler, Kirsten C.

“…Background:  Many alcoholic patients have serum protein deficiency that contributes to their systemic problems. The unfolded protein response (UPR) is induced…”
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A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry by Maier, Keith E, Jangra, Rohit K, Shieh, Kevin R, Cureton, David K, Xiao, Hui, Snapp, Erik L, Whelan, Sean P, Chandran, Kartik, Levy, Matthew

“…Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR)…”
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Monitoring Chaperone Engagement of Substrates in the Endoplasmic Reticulum of Live Cells by Snapp, Erik L., Sharma, Ajay, Lippincott-Schwartz, Jennifer, Hegde, Ramanujan S.

“…The folding environment in the endoplasmic reticulum (ER) depends on multiple abundant chaperones that function together to accommodate a range of substrates…”
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Golgi inheritance in mammalian cells is mediated through endoplasmic reticulum export activities by Altan-Bonnet, Nihal, Sougrat, Rachid, Liu, Wei, Snapp, Erik L, Ward, Theresa, Lippincott-Schwartz, Jennifer

“…Golgi inheritance during mammalian cell division occurs through the disassembly, partitioning, and reassembly of Golgi membranes. The mechanisms responsible…”
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