Search Results - "Snaedal, Jón"

Reversibility of cognitive worsening observed with BACE inhibitor umibecestat in the Alzheimer's Prevention Initiative (API) Generation Studies by Tariot, Pierre N., Riviere, Marie‐Emmanuelle, Salloway, Stephen, Burns, Jeffrey M., Snaedal, Jón G., Borowsky, Beth, Lopez, Cristina Lopez, Liu, Fonda, Rouzade‐Dominguez, Marie‐Laure, Cazorla, Pilar, Mousseau, Marie‐Catherine, Arkuszewski, Michal, Ricart, Javier, Viglietta, Vissia, Sui, Yihan, Caputo, Angelika, Langbaum, Jessica B., Reiman, Eric M., Graf, Ana

“…INTRODUCTION The Alzheimer's Prevention Initiative (API) Generation Studies evaluated the BACE inhibitor umibecestat for Alzheimer's disease (AD) prevention…”
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Case–control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: A short review by Torsdottir, Gudlaug, Kristinsson, Jakob, Snaedal, Jón, Sveinbjörnsdóttir, Sigurlaug, Gudmundsson, Grétar, Hreidarsson, Stefán, Jóhannesson, Torkell

“…Abstract This short review describes a series of case–control studies on the concentration and oxidative activity of ceruloplasmin (CP) in serum and the…”
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Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies by Kristinsson, Jakob, Snaedal, Jón, Tórsdóttir, Gudlaug, Jóhannesson, Torkell

“…Ceruloplasmin (Cp) concentration and oxidative activity in serum are lowered in Parkinson's disease (PD). In most PD patients, iron increases in the substantia…”
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Ceruloplasmin and Iron Proteins in the Serum of Patients with Alzheimer’s Disease by Torsdottir, Gudlaug, Kristinsson, Jakob, Snaedal, Jón, Jóhannesson, Torkell

“…Backgrounds/Aims: The oxidative activity of ceruloplasmin (CP) in serum has been found to be lowered in patients with Alzheimer’s disease (AD). We investigated…”
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The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study by Mårtensson, Gustav, Ferreira, Daniel, Granberg, Tobias, Cavallin, Lena, Oppedal, Ketil, Padovani, Alessandro, Rektorova, Irena, Bonanni, Laura, Pardini, Matteo, Kramberger, Milica G, Taylor, John-Paul, Hort, Jakub, Snædal, Jón, Kulisevsky, Jaime, Blanc, Frederic, Antonini, Angelo, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kłoszewska, Iwona, Soininen, Hilkka, Lovestone, Simon, Simmons, Andrew, Aarsland, Dag, Westman, Eric

“…•The performance of a deep learning model for visual ratings of atrophy was investigated in clinical out-of-distribution data.•Model is more robust on unseen…”
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Sex differences in brain atrophy in dementia with Lewy bodies by Oltra, Javier, Habich, Annegret, Schwarz, Christopher G., Nedelska, Zuzana, Przybelski, Scott A., Inguanzo, Anna, Diaz‐Galvan, Patricia, Lowe, Val J., Oppedal, Ketil, Gonzalez, Maria C., Philippi, Nathalie, Blanc, Frederic, Barkhof, Frederik, Lemstra, Afina W., Hort, Jakub, Padovani, Alessandro, Rektorova, Irena, Bonanni, Laura, Massa, Federico, Kramberger, Milica G., Taylor, John‐Paul, Snædal, Jon G., Walker, Zuzana, Antonini, Angelo, Dierks, Thomas, Segura, Barbara, Junque, Carme, Westman, Eric, Boeve, Bradley F., Aarsland, Dag, Kantarci, Kejal, Ferreira, Daniel

“…INTRODUCTION Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain…”
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline by Jonsson, Thorlakur, Atwal, Jasvinder K., Steinberg, Stacy, Snaedal, Jon, Jonsson, Palmi V., Bjornsson, Sigurbjorn, Stefansson, Hreinn, Sulem, Patrick, Gudbjartsson, Daniel, Maloney, Janice, Hoyte, Kwame, Gustafson, Amy, Liu, Yichin, Lu, Yanmei, Bhangale, Tushar, Graham, Robert R., Huttenlocher, Johanna, Bjornsdottir, Gyda, Andreassen, Ole A., Jönsson, Erik G., Palotie, Aarno, Behrens, Timothy W., Magnusson, Olafur T., Kong, Augustine, Thorsteinsdottir, Unnur, Watts, Ryan J., Stefansson, Kari

“…A coding mutation in APP , the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the…”
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Ceruloplasmin and superoxide dismutase (SOD1) in heterozygotes for Wilson disease: A case control study by Tórsdóttir, Gudlaug, Gudmundsson, Grétar, Kristinsson, Jakob, Snaedal, Jón, Jóhannesson, Torkell

“…At the time of this study, there were five known patients with Wilson disease (WD) in Iceland. The mutation, a 7-bp deletion in exon 7 on chromosome 13 for WD,…”
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A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium by Oppedal, Ketil, Ferreira, Daniel, Cavallin, Lena, Lemstra, Afina W., ten Kate, Mara, Padovani, Alessandro, Rektorova, Irena, Bonanni, Laura, Wahlund, Lars-Olof, Engedal, Knut, Nobili, Flavio, Kramberger, Milica, Taylor, John-Paul, Hort, Jakub, Snædal, Jon, Blanc, Frederic, Walker, Zuzana, Antonini, Angelo, Westman, Eric, Aarsland, Dag

“…We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). In this multicentre study, we included a total of…”
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The Power of EEG to Predict Conversion from Mild Cognitive Impairment and Subjective Cognitive Decline to Dementia by Engedal, Knut, Barca, Maria Lage, Høgh, Peter, Bo Andersen, Birgitte, Winther Dombernowsky, Nanna, Naik, Mala, Gudmundsson, Thorkell Eli, Øksengaard, Anne-Rita, Wahlund, Lars-Olof, Snaedal, Jon

“…The aim of this study was to examine if quantitative electroencephalography (qEEG) using the statistical pattern recognition (SPR) method could predict…”
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Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions by Teitsdottir, Unnur D, Jonsdottir, Maria K, Lund, Sigrun H, Darreh-Shori, Taher, Snaedal, Jon, Petersen, Petur H

“…Background Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer's disease (AD). The…”
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Quantitative EEG Applying the Statistical Recognition Pattern Method: A Useful Tool in Dementia Diagnostic Workup by Engedal, Knut, Snaedal, Jon, Hoegh, Peter, Jelic, Vesna, Bo Andersen, Birgitte, Naik, Mala, Wahlund, Lars-Olof, Oeksengaard, Anne-Rita

“…The aim of this study was to examine the discriminatory power of quantitative EEG (qEEG) applying the statistical pattern recognition (SPR) method to separate…”
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Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects by Teitsdottir, Unnur D, Darreh-Shori, Taher, Lund, Sigrun H, Jonsdottir, Maria K, Snaedal, Jon, Petersen, Petur H

“…Cholinergic drugs are the most commonly used drugs for the treatment of Alzheimer's disease (AD). Therefore, a better understanding of the cholinergic system…”
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The Association Between Midlife Physical Activity and Depressive Symptoms in Late Life: Age Gene/Environment Susceptibility-Reykjavik Study by Chang, Milan, Snaedal, Jon, Einarsson, Bjorn, Bjornsson, Sigurbjorn, Saczynski, Jane S, Aspelund, Thor, Garcia, Melissa, Gudnason, Vilmundur, Harris, Tamara B, Launer, Lenore J, Jonsson, Palmi V

“…There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife…”
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Retinal oxygen metabolism in patients with mild cognitive impairment by Olafsdottir, Olof Birna, Saevarsdottir, Hrafnhildur Sif, Hardarson, Sveinn Hakon, Hannesdottir, Kristin Hanna, Traustadottir, Valgerdur Dora, Karlsson, Robert Arnar, Einarsdottir, Anna Bryndis, Jonsdottir, Katrin Dilja, Stefansson, Einar, Snaedal, Jon

“…We have previously reported that retinal vessel oxygen saturation is increased in mild-to-moderate dementia of Alzheimer's type when compared with healthy…”
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Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study: Protocol for an Exploratory, Cross-sectional Study by Curcic, Jelena, Vallejo, Vanessa, Sorinas, Jennifer, Sverdlov, Oleksandr, Praestgaard, Jens, Piksa, Mateusz, Deurinck, Mark, Erdemli, Gul, Bügler, Maximilian, Tarnanas, Ioannis, Taptiklis, Nick, Cormack, Francesca, Anker, Rebekka, Massé, Fabien, Souillard-Mandar, William, Intrator, Nathan, Molcho, Lior, Madero, Erica, Bott, Nicholas, Chambers, Mieko, Tamory, Josef, Shulz, Matias, Fernandez, Gerardo, Simpson, William, Robin, Jessica, Snædal, Jón G, Cha, Jang-Ho, Hannesdottir, Kristin

“…More sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease…”
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Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer’s disease by Musaeus, Christian S., Engedal, Knut, Høgh, Peter, Jelic, Vesna, Khanna, Arjun R., Kjær, Troels Wesenberg, Mørup, Morten, Naik, Mala, Oeksengaard, Anne‐Rita, Santarnecchi, Emiliano, Snaedal, Jon, Wahlund, Lars‐Olof, Waldemar, Gunhild, Andersen, Birgitte B.

“…Introduction Large‐scale brain networks are disrupted in the early stages of Alzheimer's disease (AD). Electroencephalography microstate analysis, a promising…”
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Diagnostic accuracy of statistical pattern recognition of electroencephalogram registration in evaluation of cognitive impairment and dementia by Snaedal, Jon, Johannesson, Gisli Holmar, Gudmundsson, Thorkell Eli, Blin, Nicolas Petur, Emilsdottir, Asdis Lilja, Einarsson, Bjorn, Johnsen, Kristinn

“…There is still a need for simple, noninvasive, and inexpensive methods to diagnose the causes of cognitive impairment and dementia. In this study, contemporary…”
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Cerebrovascular and Alzheimer’s disease biomarkers in dementia with Lewy bodies and other dementias by Rennie, Anna, Ekman, Urban, Shams, Sara, Rydén, Lina, Samuelsson, Jessica, Zettergren, Anna, Kern, Silke, Oppedal, Ketil, Blanc, Frédéric, Hort, Jakub, Garcia-Ptacek, Sara, Antonini, Angelo, Lemstra, Afina W, Padovani, Alessandro, Kramberger, Milica Gregoric, Rektorová, Irena, Walker, Zuzana, Snædal, Jón, Pardini, Matteo, Taylor, John-Paul, Bonanni, Laura, Granberg, Tobias, Aarsland, Dag, Skoog, Ingmar, Wahlund, Lars-Olof, Kivipelto, Miia, Westman, Eric, Ferreira, Daniel

“…Abstract Co-pathologies are common in dementia with Lewy bodies and other dementia disorders. We investigated cerebrovascular and Alzheimer’s disease…”
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World Medical Association perspectives on person-centered medicine by Snaedal, Jon

“…[...]the right type of service is delivered to the right patient by doctors and other health professionals specifically trained for each particular task…”
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