Search Results - "Snaar-Jagalska"

Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis by Paauwe, Madelon, Schoonderwoerd, Mark J A, Helderman, Roxan F C P, Harryvan, Tom J, Groenewoud, Arwin, van Pelt, Gabi W, Bor, Rosalie, Hemmer, Danielle M, Versteeg, Henri H, Snaar-Jagalska, B Ewa, Theuer, Charles P, Hardwick, James C H, Sier, Cornelis F M, Ten Dijke, Peter, Hawinkels, Lukas J A C

“…Cancer-associated fibroblasts (CAF) are a major component of the colorectal cancer tumor microenvironment. CAFs play an important role in tumor progression and…”
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Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model by Drabsch, Yvette, He, Shuning, Zhang, Long, Snaar-Jagalska, B Ewa, ten Dijke, Peter

“…The transforming growth factor beta (TGF-β) signalling pathway is known to control human breast cancer invasion and metastasis. We demonstrate that the…”
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Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model by He, Shuning, Lamers, Gerda EM, Beenakker, Jan-Willem M, Cui, Chao, Ghotra, Veerander PS, Danen, Erik HJ, Meijer, Annemarie H, Spaink, Herman P, Snaar-Jagalska, B Ewa

“…Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates tumour invasiveness and micrometastasis by unknown mechanisms. To…”
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A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness by di Gennaro, Alessandra, Damiano, Valentina, Brisotto, Giulia, Armellin, Michela, Perin, Tiziana, Zucchetto, Antonella, Guardascione, Michela, Spaink, Herman P., Doglioni, Claudio, Snaar-Jagalska, B. Ewa, Santarosa, Manuela, Maestro, Roberta

“…Inactivation of p53 contributes significantly to the dismal prognosis of breast tumors, most notably triple-negative breast cancers (TNBCs). How the relief…”
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Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells by Franzetti, G-A, Laud-Duval, K, van der Ent, W, Brisac, A, Irondelle, M, Aubert, S, Dirksen, U, Bouvier, C, de Pinieux, G, Snaar-Jagalska, E, Chavrier, P, Delattre, O

“…Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1…”
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Light‐Triggered Cancer Cell Specific Targeting and Liposomal Drug Delivery in a Zebrafish Xenograft Model by Kong, Li, Chen, Quanchi, Campbell, Frederick, Snaar‐Jagalska, Ewa, Kros, Alexander

“…Cell‐specific drug delivery remains a major unmet challenge for cancer nanomedicines. Here, light‐triggered, cell‐specific delivery of liposome‐encapsulated…”
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Application of Coiled Coil Peptides in Liposomal Anticancer Drug Delivery Using a Zebrafish Xenograft Model by Yang, Jian, Shimada, Yasuhito, Olsthoorn, René C. L, Snaar-Jagalska, B. Ewa, Spaink, Herman P, Kros, Alexander

“…The complementary coiled coil forming peptides E4 [(EIAALEK)4] and K4 [(KIAALKE)4] are known to trigger liposomal membrane fusion when tethered to lipid…”
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Automated whole animal bio-imaging assay for human cancer dissemination by Ghotra, Veerander P S, He, Shuning, de Bont, Hans, van der Ent, Wietske, Spaink, Herman P, van de Water, Bob, Snaar-Jagalska, B Ewa, Danen, Erik H J

“…A quantitative bio-imaging platform is developed for analysis of human cancer dissemination in a short-term vertebrate xenotransplantation assay. Six days…”
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CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma by Karkampouna, Sofia, van der Helm, Danny, Gray, Peter C, Chen, Lanpeng, Klima, Irena, Grosjean, Joël, Burgmans, Mark C, Farina‐Sarasqueta, Arantza, Snaar‐Jagalska, Ewa B, Stroka, Deborah M, Terracciano, Luigi, van Hoek, Bart, Schaapherder, Alexander F, Osanto, Susan, Thalmann, George N, Verspaget, Hein W, Coenraad, Minneke J, Kruithof‐de Julio, Marianna

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. Despite increasing treatment options for this disease, prognosis…”
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Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion by Naber, Hildegonda P.H., Drabsch, Yvette, Snaar-Jagalska, B. Ewa, ten Dijke, Peter, van Laar, Theo

“…•Snail or Slug expression in H-Ras transformed MCF10AT induced an EMT-like phenotype.•Slug or Snail expression in H-Ras transformed MCF10AT promoted invasion…”
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Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish by Meijer, Annemarie H, Gabby Krens, S.F, Medina Rodriguez, Indira A, He, Shuning, Bitter, Wilbert, Ewa Snaar-Jagalska, B, Spaink, Herman P

“…The zebrafish genomic sequence database was analysed for the presence of genes encoding members of the Toll-like receptors (TLR) and interleukin receptors…”
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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor by Zhang, Long, Zhou, FangFang, Drabsch, Yvette, Gao, Rui, Snaar-Jagalska, B. Ewa, Mickanin, Craig, Huang, Huizhe, Sheppard, Kelly-Ann, Porter, Jeff A., Lu, Chris X., ten Dijke, Peter

“…The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is…”
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A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis by Chen, Lanpeng, De Menna, Marta, Groenewoud, Arwin, Thalmann, George N., Kruithof-de Julio, Marianna, Snaar-Jagalska, B. Ewa

“…Metastasis is a main cause of death in prostate cancer (PCa). To dissect the molecular cues from cancer cell–microenvironment interaction that drive metastatic…”
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Functions of the MAPK family in vertebrate-development by Krens, S.F. Gabby, Spaink, Herman P., Snaar-Jagalska, B. Ewa

“…The mitogen activated protein kinase (MAPK) family, consisting of the extracellular signal regulated protein kinase, c-Jun amino terminal MAPK and p38…”
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CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients by Sand, L.G.L, Scotlandi, K, Berghuis, D, Snaar-Jagalska, B.E, Picci, P, Schmidt, T, Szuhai, K, Hogendoorn, P.C.W

“…Highlights • CXCR7, CXCR4, CXCL12 , CXCL14 and CXCR4 isoforms are expressed in Ewing sarcoma. • CXCR4-1/CXCR4-2 isoform ratio and CXCL14 and CXCR7 associate…”
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Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer by Zhao, Gangyin, Forn-Cuní, Gabriel, Scheers, Marvin, Lindenbergh, Pier Pieterszoon, Yin, Jie, van Loosen, Quint, Passarini, Leonardo, Chen, Lanpeng, Snaar-Jagalska, B. Ewa

“…Metastatic colonization by circulating cancer cells is a highly inefficient process. To colonize distant organs, disseminating cancer cells must overcome many…”
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CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells by Tulotta, C., Stefanescu, C., Chen, Q., Torraca, V., Meijer, A. H., Snaar-Jagalska, B. E.

“…Developing tumors interact with the surrounding microenvironment. Myeloid cells exert both anti- and pro-tumor functions and chemokines are known to drive…”
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The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme by Torraca, Vincenzo, Tulotta, Claudia, Snaar-Jagalska, B. Ewa, Meijer, Annemarie H.

“…CXC chemokine receptor 4 plays a critical role in chemotaxis and leukocyte differentiation. Furthermore, there is increasing evidence that links this receptor…”
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Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness by Olszewski, Maciej Boleslaw, Pruszko, Magdalena, Snaar-Jagalska, Ewa, Zylicz, Alicja, Zylicz, Maciej

“…Gain‑of‑function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the…”
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Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model by Tulotta, Claudia, Stefanescu, Cristina, Beletkaia, Elena, Bussmann, Jeroen, Tarbashevich, Katsiaryna, Schmidt, Thomas, Snaar-Jagalska, B Ewa

“…Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of…”
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