Search Results - "Smyth, Lucy J. C"

CD4-regulatory cells in COPD patients by Smyth, Lucy J C, Starkey, Cerys, Vestbo, Jorgen, Singh, Dave

“…The numbers of airway CD8 and B lymphocytes are increased in COPD patients, suggesting an autoimmune process. CD4-regulatory T cells control autoimmunity but…”
Get more information

Immunological Responses in Women with Human Papillomavirus Type 16 (HPV-16)-Associated Anogenital Intraepithelial Neoplasia Induced by Heterologous Prime-Boost HPV-16 Oncogene Vaccination by SMYTH, Lucy J. C, VAN POELGEEST, Mariëtte I. E, TRISTRAM, Amanda, KITCHENER, Henry C, OFFRINGA, Rienk, STERN, Peter L, VAN DER BURG, Sjoerd H, DAVIDSON, Emma J, KWAPPENBERG, Kitty M. C, BURT, Debbie, SEHR, Peter, PAWLITA, Michael, MAN, Stephen, HICKLING, Julian K, FIANDER, Alison N

“…Purpose: The purpose is to study the immunogenicity of heterologous prime-boost human papillomavirus (HPV) oncogene vaccination in patients with anogenital…”
Get full text

Identification of Cells Expressing IL-17A and IL-17F in the Lungs of Patients With COPD by Eustace, Amanda, PhD, Smyth, Lucy J.C., PhD, Mitchell, Lorna, Williamson, Kate, MSc, Plumb, Jonathan, PhD, Singh, Dave, MD

“…Background Lymphocytes secrete IL-17A and IL-17F, which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim…”
Get full text

Increased airway T regulatory cells in asthmatic subjects by Smyth, Lucy J C, Eustace, Amanda, Kolsum, Umme, Blaikely, John, Singh, Dave

“…T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased…”
Get more information

Cd8 T‐cell recognition of human 5T4 oncofetal antigen by Smyth, Lucy JC, Elkord, Eyad, Taher, Taher E.I., Jiang, Hui‐Rong, Burt, Deborah J., Clayton, Alison, van Veelen, Peter A., de Ru, Arnoud, Ossendorp, Ferry, Melief, Cornelis J. M., Drijfhout, Jan W., Dermime, Said, Hawkins, Robert E., Stern, Peter L.

“…The 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression…”
Get full text

Assessment of the Molecular Basis of the Proallergenic Effects of Cigarette Smoke by Smyth, Lucy J. C, Machado, Denise C, Upton, Anthony P, Good, Samantha, Aufderheide, Michaela, Helm, Birgit A

“…Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying…”
Get full text

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504) by Kent, Lauren M, Smyth, Lucy J C, Plumb, Jonathan, Clayton, Chris L, Fox, Steve M, Ray, David W, Farrow, Stuart N, Singh, Dave

“…p38 mitogen-activated protein kinase (MAPK) signaling is known to be increased in chronic obstructive pulmonary disease (COPD) macrophages. We have studied the…”
Get more information

T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease by Kaur, Manminder, Smyth, Lucy Jc, Cadden, Paul, Grundy, Seamus, Ray, David, Plumb, Jonathan, Singh, Dave

“…There are increased numbers of activated lymphocytes in the lungs of chronic obstructive pulmonary disease (COPD) patients. The clinical benefits of…”
Get full text