Search Results - "Smyth, John F"

A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment by KULBE, Hagen, CHAKRAVARTY, Probir, GALLETTA, Laura, SALAKO, Michael A, SMYTH, John F, HAGEMANN, Thorsten, BRENNAN, Donal J, BOWTELL, David D, BALKWILL, Frances R, ANDREW LEINSTER, D, CHARLES, Kellie A, KWONG, Joseph, THOMPSON, Richard G, COWARD, Jermaine I, SCHIOPPA, Tiziana, ROBINSON, Stephen C, GALLAGHER, William M

“…Constitutive production of inflammatory cytokines is a characteristic of many human malignant cell lines; however, the in vitro and in vivo interdependence of…”
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Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients by SMYTH, John F, GOURLEY, Charlie, MCCURDY, Janet, MANO, Max, REED, Nick, MCMAHON, Tracey, VASEY, Paul, GABRA, Hani, LANGDON, Simon P, WALKER, Graeme, MACKEAN, Melanie J, STEVENSON, Alan, WILLIAMS, Alistair R. W, AL NAFUSSI, Awatif, RYE, Tzyvia, RYE, Ron, STEWART, Moira

“…Purpose: To evaluate the efficacy of the aromatase inhibitor letrozole in preselected estrogen receptor (ER)–positive relapsed epithelial ovarian cancer…”
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WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3 by GOURLEY, Charlie, PAIGE, Adam J. W, SMYTH, John F, GABRA, Hani, TAILOR, Karen J, WARD, Carol, KUSKE, Barbara, JIEQING ZHANG, MINGJUN SUN, JANCZAR, Szymon, HARRISON, David J, MUIR, Morwenna

“…Abstract The WW domain–containing oxidoreductase (WWOX) gene is located at FRA16D, a common fragile site involved in human cancer. Targeted deletion of Wwox in…”
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Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer by MACLEOD, Kenneth, MULLEN, Peter, SEWELL, Jane, RABIASZ, Genevieve, LAWRIE, Sandra, MILLER, Eric, SMYTH, John F, LANGDON, Simon P

“…The majority of ovarian cancer patients are treated with platinum-based chemotherapy, but the emergence of resistance to such chemotherapy severely limits its…”
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Estrogen receptor-α mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen by O’Donnell, Amanda J M, Macleod, Kenneth G, Burns, David J, Smyth, John F, Langdon, Simon P

“…Estrogens play a significant role in the development, growth, invasion and metastasis of ovarian tumors. The transcriptional program regulated by 17β-estradiol…”
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Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling by Mullen, Peter, Cameron, David A, Hasmann, Max, Smyth, John F, Langdon, Simon P

“…Pertuzumab (Omnitarg, rhuMab 2C4) is a humanized monoclonal antibody, which inhibits HER2 dimerization. Because it has shown some clinical activity in ovarian…”
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Insulin-like Growth Factor Binding Proteins IGFBP3, IGFBP4, and IGFBP5 Predict Endocrine Responsiveness in Patients with Ovarian Cancer by WALKER, Graeme, MACLEOD, Kenneth, WILLIAMS, Alistair R. W, CAMERON, David A, SMYTH, John F, LANGDON, Simon P

“…Purpose: This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian…”
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OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer by Sellar, Grant C, Gabra, Hani, Watt, Karen P, Rabiasz, Genevieve J, Stronach, Euan A, Li, Li, Miller, Eric P, Massie, Charles E, Miller, Jayne, Contreras-Moreira, Bruno, Scott, Diane, Brown, Iain, Williams, Alastair R, Bates, Paul A, Smyth, John F

“…Epithelial ovarian cancer (EOC), the leading cause of death from gynecological malignancy, is a poorly understood disease. The typically advanced presentation…”
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The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates by NTOUGKOS, Evangelos, RUSH, Robert, SCOTT, Diane, FRANKENBERG, Tobias, GABRA, Hani, SMYTH, John F, SELLAR, Grant C

“…Purpose: The IgLON family of cell adhesion molecules, comprising OPCML, HNT, LSAMP, and NEGR1, has recently been linked to cancer, through two of its members…”
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Phase I Clinical and Pharmacokinetic Study of Plitidepsin as a 1-Hour Weekly Intravenous Infusion in Patients with Advanced Solid Tumors by Miguel A. Izquierdo, Angela Bowman, Margarita García, Duncan Jodrell, Marisa Martinez, Beatriz Pardo, Javier Gómez, José A. López-Martin, José Jimeno, José R. Germá, John F. Smyth

“…Purpose: Plitidepsin, given as a 1-hour weekly i.v. infusion for 3 consecutive weeks during a 4-week treatment cycle, was investigated in patients with solid…”
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Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect by Hayward, Richard L, Macpherson, Janet S, Cummings, Jeff, Monia, Brett P, Smyth, John F, Jodrell, Duncan I

“…Oxaliplatin, licensed for colorectal cancer chemotherapy, damages DNA by generating intrastrand and interstrand cross-links and can induce apoptosis via a…”
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The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans by Charles, Kellie A, Kulbe, Hagen, Soper, Robin, Escorcio-Correia, Monica, Lawrence, Toby, Schultheis, Anne, Chakravarty, Probir, Thompson, Richard G, Kollias, George, Smyth, John F, Balkwill, Frances R, Hagemann, Thorsten

“…Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine…”
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Neuregulin Expression, Function, and Signaling in Human Ovarian Cancer Cells by GILMOUR, Lynn M. R, MACLEOD, Kenneth G, MCCAIG, Alison, SEWELL, Jane M, GULLICK, William J, SMYTH, John F, LANGDON, Simon P

“…Purpose: To investigate the expression and function of neuregulin (NRG) isoforms in ovarian cancer cell lines and tumor samples. Experimental Design:…”
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Antisense Bcl-xl Down-Regulation Switches the Response to Topoisomerase I Inhibition from Senescence to Apoptosis in Colorectal Cancer Cells, Enhancing Global Cytotoxicity by HAYWARD, Richard L, MACPHERSON, Janet S, CUMMINGS, Jeff, MONIA, Brett P, SMYTH, John F, JODRELL, Duncan I

“…Purpose: To identify determinants of the effect of antisense-mediated Bcl-xl down-regulation (Bcl-xl knockdown) on the response of colorectal cancer cells to…”
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The Old Order Changeth – A valedictory from the Editor-in-Chief by Smyth, John F

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Association of galectin-3 expression with melanoma progression and prognosis by Brown, Ewan R, Doig, Tamasin, Anderson, Niall, Brenn, Thomas, Doherty, Val, Xu, Yan, Bartlett, John M.S, Smyth, John F, Melton, David W

“…Abstract Aims Galectin-3 plays an important role in adhesion, proliferation, differentiation, angiogenesis and metastasis in multiple tumours. To investigate…”
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Endometrioid Epithelial Ovarian Cancer : 20 Years of Prospectively Collected Data From a Single Center by STOREY, Dawn J, RUSH, Robert, STEWART, Moira, RYE, Tzyvia, AL-NAFUSSI, Awatif, WILLIAMS, Alistair R, SMYTH, John F, GABRA, Hani

“…Clinicopathological features and outcome of women with endometrioid and serous ovarian adenocarcinoma were compared. Between 1984 and 2004, baseline and…”
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Communication as important as cure by Smyth, John F

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What to do after winning the Nobel Prize – Work harder by Smyth, John F

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Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer by Walker, Graeme, MacLeod, Kenneth, Williams, Alistair R.W, Cameron, David A, Smyth, John F, Langdon, Simon P

“…Abstract Objective To explore the predictive value of estrogen-regulated gene changes as indicators of sensitivity in ovarian cancer patients treated with the…”
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