Search Results - "Smyth, C D"

Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae by Brunaugh, Ashlee D, Seo, Hyojong, Warnken, Zachary, Ding, Li, Seo, Sang Heui, Smyth, Hugh D C

“…Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Though NIC is…”
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Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms by Armijo, Leisha M, Wawrzyniec, Stephen J, Kopciuch, Michael, Brandt, Yekaterina I, Rivera, Antonio C, Withers, Nathan J, Cook, Nathaniel C, Huber, Dale L, Monson, Todd C, Smyth, Hugh D C, Osiński, Marek

“…Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common…”
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Unique and shared inflammatory profiles of human brain endothelia and pericytes by Smyth, Leon C D, Rustenhoven, Justin, Park, Thomas I-H, Schweder, Patrick, Jansson, Deidre, Heppner, Peter A, O'Carroll, Simon J, Mee, Edward W, Faull, Richard L M, Curtis, Maurice, Dragunow, Mike

“…Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the…”
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Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders by Brunaugh, Ashlee D, Wu, Tian, Kanapuram, Sekhar R, Smyth, Hugh D. C

“…Pulmonary delivery of biopharmaceuticals may enable targeted local therapeutic effect and noninvasive systemic administration. Dry powder inhaler (DPI)…”
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Excipient-Free Pulmonary Delivery and Macrophage Targeting of Clofazimine via Air Jet Micronization by Brunaugh, Ashlee D, Jan, Syed Umer, Ferrati, Silvia, Smyth, Hugh D. C

“…Clofazimine (CFZ) is highly active against mycobacterium, including resistant Mycobacterium tuberculosis, but its therapeutic efficacy via the oral route is…”
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Connectosomes for Direct Molecular Delivery to the Cellular Cytoplasm by Gadok, Avinash K, Busch, David J, Ferrati, Silvia, Li, Brian, Smyth, Hugh D. C, Stachowiak, Jeanne C

“…Transport of biomolecules, drugs, and other reagents across the cell’s plasma membrane barrier is an inefficient and poorly controlled process, despite its…”
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Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease by Smyth, Leon C D, Murray, Helen C, Hill, Madison, van Leeuwen, Eve, Highet, Blake, Magon, Nicholas J, Osanlouy, Mahyar, Mathiesen, Sophie N, Mockett, Bruce, Singh-Bains, Malvindar K, Morris, Vanessa K, Clarkson, Andrew N, Curtis, Maurice A, Abraham, Wickliffe C, Hughes, Stephanie M, Faull, Richard L M, Kettle, Anthony J, Dragunow, Mike, Hampton, Mark B

“…Neutrophil accumulation is a well-established feature of Alzheimer's disease (AD) and has been linked to cognitive impairment by modulating disease-relevant…”
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Feasibility of a High-Dose Inhaled Indomethacin Dry Powder with Dual Deposition for Pulmonary and Oral Delivery by Spahn, Jamie E, Hefnawy, Amr, Zhang, Feng, Smyth, Hugh D C

“…In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically,…”
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Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress by Stevenson, Taylor J., Johnson, Rebecca H., Savistchenko, Jimmy, Rustenhoven, Justin, Woolf, Zoe, Smyth, Leon C. D., Murray, Helen C., Faull, Richard L. M., Correia, Jason, Schweder, Patrick, Heppner, Peter, Turner, Clinton, Melki, Ronald, Dieriks, Birger V., Curtis, Maurice A., Dragunow, Michael

“…Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn)…”
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Controlled Release Pulmonary Administration of Curcumin Using Swellable Biocompatible Microparticles by El-Sherbiny, Ibrahim M, Smyth, Hugh D. C

“…This study involves a promising approach to achieve sustained pulmonary drug delivery. Dry powder particulate carriers were engineered to allow simultaneous…”
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Externally controlled triggered-release of drug from PLGA micro and nanoparticles by Hua, Xin, Tan, Shengnan, Bandara, H M H N, Fu, Yujie, Liu, Siguo, Smyth, Hugh D C

“…Biofilm infections are extremely hard to eradicate and controlled, triggered and controlled drug release properties may prolong drug release time. In this…”
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Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis by Swanson, Molly E V, Scotter, Emma L, Smyth, Leon C D, Murray, Helen C, Ryan, Brigid, Turner, Clinton, Faull, Richard L M, Dragunow, Mike, Curtis, Maurice A

“…In Alzheimer's disease (AD), microglia are affected by disease processes, but may also drive pathogenesis. AD pathology-associated microglial populations have…”
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Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres by El-Sherbiny, Ibrahim M., Smyth, Hugh D.C.

“…Design of appropriate inhaled carriers with adequate aerodynamic properties, drug release, biodegradation and evasion of macrophage uptake is a major challenge…”
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The Display of Single-Domain Antibodies on the Surfaces of Connectosomes Enables Gap Junction-Mediated Drug Delivery to Specific Cell Populations by Gadok, Avinash K, Zhao, Chi, Meriwether, Amanda I, Ferrati, Silvia, Rowley, Tanner G, Zoldan, Janet, Smyth, Hugh D. C, Stachowiak, Jeanne C

“…Gap junctions, transmembrane protein channels that directly connect the cytoplasm of neighboring cells and enable the exchange of molecules between cells, are…”
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Precision Ocular Drug Delivery Via Aerosol Ring Vortices by Herpin, Matthew J., Smyth, Hugh D. C.

“…Purpose Despite being the most prominent dosage form for topical ocular delivery, eye-drops have several well-recognized drawbacks. Addressing these…”
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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease by Smyth, Leon C. D., Highet, Blake, Jansson, Deidre, Wu, Jane, Rustenhoven, Justin, Aalderink, Miranda, Tan, Adelie, Li, Susan, Johnson, Rebecca, Coppieters, Natacha, Handley, Renee, Narayan, Pritika, Singh-Bains, Malvindar K., Schweder, Patrick, Turner, Clinton, Mee, Edward W., Heppner, Peter, Correia, Jason, Park, Thomas I.-H., Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike

“…Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of…”
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Improved Biofilm Antimicrobial Activity of Polyethylene Glycol Conjugated Tobramycin Compared to Tobramycin in Pseudomonas aeruginosa Biofilms by Du, Ju, Bandara, H. M. H. N, Du, Ping, Huang, Hui, Hoang, Khang, Nguyen, Dang, Mogarala, Sri Vasudha, Smyth, Hugh D. C

“…The objective of this study was to develop a functionally enhanced antibiotic that would improve the therapeutic activity against bacterial biofilms…”
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Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments by Zhang, Hairui, Leal, Jasmim, Soto, Melissa R., Smyth, Hugh D. C., Ghosh, Debadyuti

“…Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and…”
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Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels by Mazzitelli, Jose A., Smyth, Leon C. D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan

“…It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull…”
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Formulation approaches to short interfering RNA and MicroRNA: challenges and implications by Guzman-Villanueva, Diana, El-Sherbiny, Ibrahim M, Herrera-Ruiz, Dea, Vlassov, Alexander V, Smyth, Hugh D C

“…RNA interference has emerged as a potentially powerful tool in the treatment of genetic and acquired diseases by delivering short interfering RNA (siRNA) or…”
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