Search Results - "Smyth, Brendan J."

Targeted Amelioration of Cisplatin-Induced Ototoxicity in Guinea Pigs by Mohan, Shaulnie, Smyth, Brendan J., Namin, Arya, Phillips, Grady, Gratton, Michael Anne

“…This pilot study compared otoprotection provided by trans-tympanic formulations and systemic intraperitoneal administration of L-N-acetylcysteine from…”
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Point-of-Care Glucose and Lipid Profile Measures Using a Human Point-of-Care Device in Mouse Models of Type 2 Diabetes Mellitus, Aging, and Alzheimer Disease by Smyth, Brendan J, Polaski, Rachel S, Safer, Anton, Boettcher, Flint A, Konrad-Martin, Dawn, Gratton, Michael A

“…A point-of-care (POC) device to measure mouse glucose and lipid profiles is an important unmet need for cost-effective, immediate decision making in research…”
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A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials by Young, Tina C., Srinivasan, Subasree, Vetter, Marion L., Sethuraman, Venkat, Bhagwagar, Zubin, Zwirtes, Ricardo, Narasimhan, Premkumar, Chuang, Tilda, Smyth, Brendan J.

“…A systematic review of the Bristol‐Myers Squibb normal healthy volunteers (NHVs) database identified phase 1 trials that included NHVs administered placebo…”
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A Multinational, Multicenter Study Mapping Models of Kidney Supportive Care Practice by Marsh, Seren, Varghese, Amanda, Snead, Charlotte M., Hole, Barnaby D., O’Hara, Daniel V., Agarwal, Neeru, Stallworthy, Elizabeth, Caskey, Fergus J., Smyth, Brendan J., Ducharlet, Kathryn

“…Kidney supportive care (KSC) integrates kidney and palliative care to improve quality of life for people with chronic kidney disease (CKD). Despite increasing…”
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A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis by Allen, Coburn H, Goldman, Ran D, Bhatt, Seema, Simon, Harold K, Gorelick, Marc H, Spandorfer, Philip R, Spiro, David M, Mace, Sharon E, Johnson, David W, Higginbotham, Eric A, Du, Hongyan, Smyth, Brendan J, Schermer, Carol R, Goldstein, Stuart L

“…Compare the efficacy and safety of Plasma-Lyte A (PLA) versus 0.9 % sodium chloride (NaCl) intravenous (IV) fluid replacement in children with moderate to…”
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Cisplatin: continuous versus bolus by Gratton, Michael Anne, Smyth, Brendan J

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Personal digital assistant-based drug reference software as tools to improve rational prescribing: Benchmark criteria and performance by Knollmann, Björn C., Smyth, Brendan J., Garnett, Christine E., Salesiotis, Anastasios N., Gvozdjan, Dragoslav M., Berry, N. Seth, Lee, Howard, Min, F. David

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Strial marginal cells play a role in basement membrane homeostasis: In vitro and in vivo evidence by Gratton, Michael Anne, Meehan, Daniel T, Smyth, Brendan J, Cosgrove, Dominic

“…The interaction of extracellular matrix and receptors plays a role in tissue homeostasis. The thickened strial capillary basement membrane (SCBM) reported in…”
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Point-of-Care Glucose and Lipid Profile Measures Using a Human Point-of-Care Device in Mouse Models of Type 2 Diabetes Mellitus, Aging, and Alzheimer Disease by Smyth, Brendan J, Polaski, Rachel S, Safer, Anton, Boettcher, Flint A, Konrad-Martin, Dawn, Gratton, Michael Anne

“…A point-of-care (POC) device to measure mouse glucose and lipid profiles is an important unmet need for cost-effective, immediate decision making in research…”
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A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials: Journal of Clinical Pharmacology by Young, Tina C., Srinivasan, Subasree, Vetter, Marion L., Sethuraman, Venkat, Bhagwagar, Zubin, Zwirtes, Ricardo, Narasimhan, Premkumar, Chuang, Tilda, Smyth, Brendan J.

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Aminoglycoside antibiotics alter the electrogenic transport properties of cultured human proximal tubule cells by Todd, J H, Sens, D A, Hazen-Martin, D J, Bylander, J E, Smyth, B J, Sens, M A

“…Monolayers of human proximal tubule (HPT) cells, when grown on permeable supports and mounted in Ussing chambers, spontaneously display a transepithelial…”
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Recent Advances in the Cell Biology of Polycystic Kidney Disease by Smyth, Brendan J, Snyder, Richard W, Balkovetz, Daniel F, Lipschutz, Joshua H

“…Autosomal dominant polycýstic kidney disease (ADPKD) is a significant familial disorder, crossing multiple ethnicities as well as organ systems. The goal of…”
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Electrical and Freeze-Fracture Analysis of the Effects of Ionic Cadmium on Cell Membranes of Human Proximal Tubule Cells by Hazen-Martin, Debra J., Todd, John H., Sens, Mary Ann, Khan, Wasil, Bylander, John E., Smyth, Brendan J., Sens, Donald A.

“…We previously reported that cell cultures of human proximal tubule (HPT) cells respond to ionic cadmium in a manner consistent with well-defined Cd2+-elicited…”
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Effect of postmortem autolysis on Na,K-ATPase activity and antigenicity in the gerbil cochlea by Vincent, Daniel A., Gratton, Michael Anne, Smyth, Brendan J., Schulte, Bradley A.

“…Alterations in the enzymatic activity and antigenicity of Na,K-ATPase as well as changes in cochlear morphology were assessed in gerbil inner ears harvested at…”
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Selective exposure of human proximal tubule cells to gentamicin provides evidence for a basolateral component of toxicity by Smyth, B J, Todd, J H, Bylander, J E, Sens, D A, Sens, M A

“…The goal of the present study was to determine if cultured human proximal tubule (HPT) cells could provide evidence for a basolateral component of gentamicin…”
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Variation in the Electrical Properties of Cultured Human Proximal Tubule Cells by Todd, John H., Sens, Mary Ann, Hazen-Martin, Debra J., Bylander, John E., Smyth, Brendan J., Sens, Donald A.

“…Monolayers of human proximal tubule (HPT) cells, when grown on permeable supports and mounted in Ussing chambers, spontaneously display a transepithelial…”
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Serum-Free Culture and Characterization of Renal Epithelial Cells Isolated from Human Fetal Kidneys of Varying Gestational Age by Hazen-Martin, Debra J., Betty I. Tarnowski, Todd, John H., Sens, Mary Ann, Bylander, John E., Smyth, Brendan J., Garvin, A. Julian, Sens, Donald A.

“…Cell cultures were initiated from seven human fetal kidneys that varied in gestational age from 90 days to newborn. The growth medium utilized was a 1:1…”
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