Search Results - "Smyrk, Tom"

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states by Sarver, Aaron L, French, Amy J, Borralho, Pedro M, Thayanithy, Venugopal, Oberg, Ann L, Silverstein, Kevin A T, Morlan, Bruce W, Riska, Shaun M, Boardman, Lisa A, Cunningham, Julie M, Subramanian, Subbaya, Wang, Liang, Smyrk, Tom C, Rodrigues, Cecilia M P, Thibodeau, Stephen N, Steer, Clifford J

“…Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding…”
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Pathology Features in Bethesda Guidelines Predict Colorectal Cancer Microsatellite Instability: A Population-Based Study by Jenkins, Mark A, Hayashi, Shinichi, O’Shea, Anne-Marie, Burgart, Lawrence J, Smyrk, Tom C, Shimizu, David, Waring, Paul M, Ruszkiewicz, Andrew R, Pollett, Aaron F, Redston, Mark, Barker, Melissa A, Baron, John A, Casey, Graham R, Dowty, James G, Giles, Graham G, Limburg, Paul, Newcomb, Polly, Young, Joanne P, Walsh, Michael D, Thibodeau, Stephen N, Lindor, Noralane M, LeMarchand, Loïc, Gallinger, Steven, Haile, Robert W, Potter, John D, Hopper, John L, Jass, Jeremy R

“…Background & Aims: The revised Bethesda guidelines for Lynch syndrome recommend microsatellite instability (MSI) testing all colorectal cancers in patients…”
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Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant Hepatic Parenchymal Disease by Gleeson, Ferga C, Clayton, Amy C, Zhang, Lizhi, Clain, Jonathan E, Gores, Gregory J, Rajan, Elizabeth, Smyrk, Tom C, Topazian, Mark D, Wang, Kenneth K, Wiersema, Maurits J, Levy, Michael J

“…Background & Aims The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy have not been determined. Therefore, our aim was to determine…”
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Multiple jejunal cancers resulting from combination of germline APC and MLH1 mutations by Lindor, Noralane M., Smyrk, Tom C., Buehler, Sheila, Gunawardena, Shanaka R., Thomas, Brittany C., Limburg, Paul, Kirmani, Salman, Thibodeau, Stephen N.

“…Double heterozygotes for mutations in APC and a DNA mismatch repair gene are extremely rare. We report on an individual who had truncating mutations in APC and…”
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Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members by Watson, Patrice, Lin, Kevin M., Rodriguez‐Bigas, Miguel A., Smyrk, Tom, Lemon, Stephen, Shashidharan, M., Franklin, Barbara, Karr, Beth, Thorson, Alan, Lynch, Henry T.

“…BACKGROUND Patients with hereditary nonpolyposis colorectal carcinoma (HNPCC) reportedly have better prognoses than sporadic colorectal carcinoma (CRC)…”
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NSAID enteropathy: appearance at CT and MR enterography in the age of multi-modality imaging and treatment by Frye, Judson M, Hansel, Stephanie L, Dolan, Steven G, Fidler, Jeff L, Song, Louis M Wong Kee, Barlow, John M, Smyrk, Tom C, Flicek, Kristina T, Hara, Amy K, Bruining, David H, Fletcher, Joel G

“…CT and MR enterography and capsule endoscopy are increasingly used as routine diagnostic tests for patients with potential small bowel disorders and obscure…”
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Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma by Moskaluk, C A, Hruban, R H, Schutte, M, Lietman, A S, Smyrk, T, Fusaro, L, Fusaro, R, Lynch, J, Yeo, C J, Jackson, C E, Lynch, H T, Kern, S E

“…A first-degree relative with pancreatic cancer is found in 5% to 10% of patients with pancreatic carcinomas, suggesting an inherited predisposition for this…”
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The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival by Rahman, Meher K, Midtling, Emilie H, Svingen, Phyllis A, Xiong, Yuning, Bell, Michael P, Tung, Jeanne, Smyrk, Tom, Egan, Larry J, Faubion, Jr, William A

“…The expression of pathogen recognition receptors in human FOXP3+ T regulatory cells is established, yet the function of these receptors is currently obscure…”
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Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II) by Lynch, H T, Watson, P, Lanspa, S J, Marcus, J, Smyrk, T, Fitzgibbons, Jr, R J, Kriegler, M, Lynch, J F

“…Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical…”
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Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II) by Lynch, H T, Watson, P, Kriegler, M, Lynch, J F, Lanspa, S J, Marcus, J, Smyrk, T, Fitzgibbons, Jr, R J, Cristofaro, G

“…Increasing recognition of the statistical burden posed by HNPCC (5 to 6 percent of all colorectal cancer) mandates that physicians have a better understanding…”
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Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage by NYSTRÖM-LAHTI, M, PARSONS, R, CAVALIERI, J, LYNCH, J, LANSPA, S, SMYRK, T, LYNCH, P, DROUHARD, T, KINZLER, K. W, VOGELSTEIN, B, LYNCH, H. T, DE LA CHAPELLE, A, SISTONEN, P, PELTOMÄKI, P, PYLKKÄNEN, L, AALTONEN, L. A, LEACH, F. S, HAMILTON, S. R, WATSON, P, BRONSON, E, FUSARO, R

“…Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on…”
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Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux by WETSCHER, G. J, HINDER, R. A, SMYRK, T, PERDIKIS, G, ADRIAN, T. E, PROFANTER, C

“…Duodenogastric reflux (DGR) in rats causes growth stimulation of the foregut mucosa that is potentiated by gastric acid blockade. It was the aim of this study…”
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Experimental and clinical results with proximal end-to-end duodenojejunostomy for pathologic duodenogastric reflux by DEMEESTER, T. R, FUCHS, K. H, BALL, C. S, ALBERTUCCI, M, SMYRK, T. C, MARCUS, J. N

“…Existing Roux-en-Y bile diversion procedures for duodenogastric reflux coupled with distal gastric resection or antrectomy and vagotomy have varied success due…”
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A new intraluminal antigastroesophageal reflux procedure in baboons by Mason, Rodney J., Filipi, Charles J., DeMeester, Tom R., Peters, Jeffrey H., Lund, Richard J., Flake, Alan W., Hinder, Ronald A., Smyrk, Tom C., Bremner, Cedric G., Thompson, Suzanne

“…Background: A new endoscopic intraluminal procedure (valvuloplasty) was designed to provide a simple, easy approach to the cardia and to correct and augment…”
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Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade by WETSCHER, G. J, HINDER, R. A, KRETCHMAR, D, STINSON, R, PERDIKIS, G, SMYRK, T, KLINGLER, P. J, ADRIAN, T. E

“…We investigated whether duodenogastric reflux (DGR) together with gastroesophageal reflux causes growth stimulation of the foregut mucosa and if additional…”
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Novel germline p16INK4 allele (Asp145Cys) in a family with multiple pancreatic carcinomas by Moskaluk, Christopher A., Hruban, Ralph H., Lietman, Amanda, Smyrk, Tom, Fusaro, Lavonne, Fusaro, Ramon, Lynch, Jane, Yeo, Charles J., Jackson, Charles E., Lynch, Henry T., Kern, Scott E.

“…As part of a search for causative genes of familial pancreatic carcinoma, the p16 genes were sequenced in members of 21 families with a phenotype of familial…”
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Novel germline p16 [sup]INK4 allele (Asp145Cys) in a family with multiple pancreatic carcinomas by Moskaluk, Christopher A, Hruban, Ralph H, Lietman, Amanda, Smyrk, Tom, Fusaro, Lavonne, Fusaro, Ramon, Lynch, Jane, Yeo, Charles J, Jackson, Charles E, Lynch, Henry T, Kern, Scott E

“…As part of a search for causative genes of familial pancreatic carcinoma, the p16 genes were sequenced in members of 21 families with a phenotype of familial…”
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Flat adenomas in a colon cancer-prone kindred by Lynch, H T, Smyrk, T, Lanspa, S J, Marcus, J N, Kriegler, M, Lynch, J F, Appelman, H D

“…We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with…”
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Hereditary nonpolyposis colorectal cancer--Lynch syndromes I and II by Lynch, H T, Lanspa, S J, Boman, B M, Smyrk, T, Watson, P, Lynch, J F, Lynch, P M, Cristofaro, G, Bufo, P, Tauro, A V

“…HNPCC is an autosomal dominantly inherited disorder with proclivity to early onset colorectal cancer in the absence of multiple polyps of the colon. There is a…”
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Laryngeal carcinoma in a Lynch syndrome II kindred by Lynch, H T, Kriegler, M, Christiansen, T A, Smyrk, T, Lynch, J F, Watson, P

“…Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for about 4% to 6% of the total colorectal cancer burden. It is subdivided into Lynch syndrome I and…”
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