Search Results - "Smyllie, J"

Cell-autonomous clock of astrocytes drives circadian behavior in mammals by Brancaccio, Marco, Edwards, Mathew D, Patton, Andrew P, Smyllie, Nicola J, Chesham, Johanna E, Maywood, Elizabeth S, Hastings, Michael H

“…Circadian (~24-hour) rhythms depend on intracellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks…”
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Regulating the Suprachiasmatic Nucleus (SCN) Circadian Clockwork: Interplay between Cell-Autonomous and Circuit-Level Mechanisms by Herzog, Erik D, Hermanstyne, Tracey, Smyllie, Nicola J, Hastings, Michael H

“…The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing daily cycles of behavior and physiology. SCN neurons contain a…”
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Molecular-genetic Manipulation of the Suprachiasmatic Nucleus Circadian Clock by Hastings, Michael H., Smyllie, Nicola J., Patton, Andrew P.

“…Circadian (approximately daily) rhythms of physiology and behaviour adapt organisms to the alternating environments of day and night. The suprachiasmatic…”
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The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit by Patton, Andrew P., Edwards, Mathew D., Smyllie, Nicola J., Hamnett, Ryan, Chesham, Johanna E., Brancaccio, Marco, Maywood, Elizabeth S., Hastings, Michael H.

“…The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To…”
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Temporally chimeric mice reveal flexibility of circadian period-setting in the suprachiasmatic nucleus by Smyllie, Nicola J., Chesham, Johanna E., Hamnett, Ryan, Maywood, Elizabeth S., Hastings, Michael H.

“…The suprachiasmatic nucleus (SCN) is the master circadian clock controlling daily behavior in mammals. It consists of a heterogeneous network of neurons, in…”
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The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis by Parsons, Michael J., Brancaccio, Marco, Sethi, Siddharth, Maywood, Elizabeth S., Satija, Rahul, Edwards, Jessica K., Jagannath, Aarti, Couch, Yvonne, Finelli, Mattéa J., Smyllie, Nicola J., Esapa, Christopher, Butler, Rachel, Barnard, Alun R., Chesham, Johanna E., Saito, Shoko, Joynson, Greg, Wells, Sara, Foster, Russell G., Oliver, Peter L., Simon, Michelle M., Mallon, Ann-Marie, Hastings, Michael H., Nolan, Patrick M.

“…We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3Sci), which accelerates circadian locomotor…”
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Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2 by Smyllie, Nicola J., Pilorz, Violetta, Boyd, James, Meng, Qing-Jun, Saer, Ben, Chesham, Johanna E., Maywood, Elizabeth S., Krogager, Toke P., Spiller, David G., Boot-Handford, Raymond, White, Michael R.H., Hastings, Michael H., Loudon, Andrew S.I.

“…Transcriptional-translational feedback loops (TTFLs) are a conserved molecular motif of circadian clocks. The principal clock in mammals is the suprachiasmatic…”
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Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator by Yang, Nan, Smyllie, Nicola J, Morris, Honor, Gonçalves, Cátia F, Dudek, Michal, Pathiranage, Dharshika R J, Chesham, Johanna E, Adamson, Antony, Spiller, David G, Zindy, Egor, Bagnall, James, Humphreys, Neil, Hoyland, Judith, Loudon, Andrew S I, Hastings, Michael H, Meng, Qing-Jun

“…Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments…”
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Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock by Koch, Alex A, Bagnall, James S, Smyllie, Nicola J, Begley, Nicola, Adamson, Antony D, Fribourgh, Jennifer L, Spiller, David G, Meng, Qing-Jun, Partch, Carrie L, Strimmer, Korbinian, House, Thomas A, Hastings, Michael H, Loudon, Andrew S I

“…The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool…”
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Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse by Maywood, Elizabeth S., Drynan, Lesley, Chesham, Johanna E., Edwards, Mathew D., Dardente, Hugues, Fustin, Jean-Michel, Hazlerigg, David G., O'Neill, John S., Codner, Gemma F., Smyllie, Nicola J., Brancaccio, Marco, Hastings, Michael H.

“…The suprachiasmatic nucleus (SCN) coordinates circadian rhythms that adapt the individual to solar time. SCN pacemaking revolves around feedback loops in which…”
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Astrocytes Sustain Circadian Oscillation and Bidirectionally Determine Circadian Period, But Do Not Regulate Circadian Phase in the Suprachiasmatic Nucleus by Patton, Andrew P, Smyllie, Nicola J, Chesham, Johanna E, Hastings, Michael H

“…The suprachiasmatic nucleus (SCN) is the master circadian clock of mammals, generating and transmitting an internal representation of environmental time that…”
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Neuron-Astrocyte Interactions and Circadian Timekeeping in Mammals by Smyllie, Nicola J, Hastings, Michael H, Patton, Andrew P

“…Almost every facet of our behavior and physiology varies predictably over the course of day and night, anticipating and adapting us to their associated…”
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PERfect Day: reversible and dose‐dependent control of circadian time‐keeping in the mouse suprachiasmatic nucleus by translational switching of PERIOD2 protein expression by McManus, David, Patton, Andrew P., Smyllie, Nicola J., Chin, Jason W., Hastings, Michael H.

“…The biological clock of the suprachiasmatic nucleus (SCN) orchestrates circadian (approximately daily) rhythms of behaviour and physiology that underpin…”
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Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching by McManus, David, Polidarova, Lenka, Smyllie, Nicola J, Patton, Andrew P, Chesham, Johanna E, Maywood, Elizabeth S, Chin, Jason W, Hastings, Michael H

“…The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal clock driving circadian rhythms of physiology and behavior that adapt mammals to…”
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Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons by Smyllie, Nicola J, Bagnall, James, Koch, Alex A, Niranjan, Dhevahi, Polidarova, Lenka, Chesham, Johanna E, Chin, Jason W, Partch, Carrie L, Loudon, Andrew S I, Hastings, Michael H

“…The ∼20,000 cells of the suprachiasmatic nucleus (SCN), the master circadian clock of the mammalian brain, coordinate subordinate cellular clocks across the…”
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Differential roles for cryptochromes in the mammalian retinal clock by Wong, Jovi C. Y., Smyllie, Nicola J., Banks, Gareth T., Pothecary, Carina A., Barnard, Alun R., Maywood, Elizabeth S., Jagannath, Aarti, Hughes, Steven, Horst, Gijsbertus T. J., MacLaren, Robert E., Hankins, Mark W., Hastings, Michael H., Nolan, Patrick M., Foster, Russell G., Peirson, Stuart N.

“…Cryptochromes 1 and 2 (CRY1/2) are key components of the negative limb of the mammalian circadian clock. Like many peripheral tissues, Cry1 and ‐2 are…”
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Late potentials and ventricular enlargement after myocardial infarction : a new role for high-resolution electrocardiography ? by ZAMAN, A. G, MORRIS, J. L, SMYLLIE, J. H, COWAN, J. C

“…Arrhythmias are common in patients who have developed ventricular enlargement after myocardial infarction. A prospective study was undertaken to assess the…”
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Nitrates in myocardial infarction: influence on infarct size, reperfusion, and ventricular remodelling by Morris, J. L., Zaman, A. G., Smyllie, J. H., Cowan, J. C.

“…OBJECTIVE--To assess the possible benefits of intravenous isosorbide dinitrate in acute myocardial infarction and oral isosorbide mononitrate in subacute…”
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Ventricular dilation after anterior ST-elevation myocardial infarction in the thrombolytic era by Zaman, Azfar G., Helft, Gerard, Worthley, Stephen G., Morris, John L., Smyllie, John H.

“…Background The aim of this work was to study changes in end-diastolic volume 6 months after Q-wave and non-Q-wave anterior ST-elevation myocardial infarction…”
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Advantages of colour flow imaging in the diagnosis of left ventricular pseudoaneurysm by Sutherland, G R, Smyllie, J H, Roelandt, J R

“…Eleven cases of left ventricular pseudoaneurysm in nine patients were studied by cross sectional echocardiography, conventional Doppler echocardiography, and…”
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