Search Results - "Smurnyy, Yegor"

Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells by Heffner, Garrett C., Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J., Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A., Garijo, Olivia, Torbett, Bruce E., Horton, Holly, Finer, Mitchell H., Gregory, Philip D., Veres, Gabor

“…Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34+ hematopoietic stem and progenitor cells (HSPCs)…”
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NMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic Interactions by Feeney, James, Birdsall, Berry, Kovalevskaya, Nadezhda V, Smurnyy, Yegor. D, Navarro Peran, Emna M, Polshakov, Vladimir I

“…In order to examine the origins of the large positive cooperativity (ΔG 0 coop = −2.9 kcal mol−1) of trimethoprim (TMP) binding to a bacterial dihydrofolate…”
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DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells by Smurnyy, Yegor, Cai, Mi, Wu, Hua, McWhinnie, Elizabeth, Tallarico, John A, Yang, Yi, Feng, Yan

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Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells by Lewis, Gretchen, Christiansen, Lauryn, McKenzie, Jessica, Luo, Min, Pasackow, Eli, Smurnyy, Yegor, Harrington, Sean, Gregory, Philip, Veres, Gabor, Negre, Olivier, Bonner, Melissa

“…Lentiviral vector (LVV)-mediated transduction of human CD34 hematopoietic stem and progenitor cells (HSPCs) holds tremendous promise for the treatment of…”
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Computer-assisted methods for molecular structure elucidation: realizing a spectroscopist's dream by Elyashberg, Mikhail, Blinov, Kirill, Molodtsov, Sergey, Smurnyy, Yegor, Williams, Antony J, Churanova, Tatiana

“…Background This article coincides with the 40 year anniversary of the first published works devoted to the creation of algorithms for computer-aided structure…”
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Exceptionally Facile CO Addition to a Saturated Ruthenium Complex by Bibal, Christine, Smurnyy, Yegor D, Pink, Maren, Caulton, Kenneth G

“…Synthesis and characterization of Cp*Ru[η3-HC(PPh2NPh)2], 1, reveals it to have a “piano stool” structure with the ligand bound to Ru(II) via two N and the…”
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Empirical and DFT GIAO quantum-mechanical methods of 13C chemical shifts prediction: competitors or collaborators? by Elyashberg, Mikhail, Blinov, Kirill, Smurnyy, Yegor, Churanova, Tatiana, Williams, Antony

“…The accuracy of 13C chemical shift prediction by both DFT GIAO quantum‐mechanical (QM) and empirical methods was compared using 205 structures for which…”
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Toward More Reliable 13C and 1H Chemical Shift Prediction:  A Systematic Comparison of Neural-Network and Least-Squares Regression Based Approaches by Smurnyy, Yegor D, Blinov, Kirill A, Churanova, Tatiana S, Elyashberg, Mikhail E, Williams, Antony J

“…The efficacy of neural network (NN) and partial least-squares (PLS) methods is compared for the prediction of NMR chemical shifts for both 1H and 13C nuclei…”
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Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH by Kovalevskaya, Nadezhda V, Smurnyy, Yegor D, Polshakov, Vladimir I, Birdsall, Berry, Bradbury, Alan F, Frenkiel, Tom, Feeney, James

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Multifunctional behavior by a Bis-(phosphinimino)methanide ligand: eta 2- vs eta 3-coordination vs Bronsted basicity by Bibal, Christine, Pink, Maren, Smurnyy, Yegor D, Tomaszewski, John, Caulton, Kenneth G

“…The reaction of [(Cymene)RuCl2]2 with the chelate LiHC(PPh2NPh)2 occurs to remove both chloride ligands, to furnish a cationic Ru(II) complex with the…”
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Multifunctional Behavior by a Bis-(phosphinimino)methanide Ligand:  η2- vs η3-coordination vs Bronsted Basicity by Bibal, Christine, Pink, Maren, Smurnyy, Yegor D, Tomaszewski, John, Caulton, Kenneth G

“…The reaction of [(Cymene)RuCl2]2 with the chelate LiHC(PPh2NPh)2 occurs to remove both chloride ligands, to furnish a cationic Ru(II) complex with the…”
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DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells by Smurnyy, Yegor, Cai, Mi, Wu, Hua, McWhinnie, Elizabeth, Tallarico, John A, Yang, Yi, Feng, Yan

“…Drug-resistance mutations provide a classical means to identify biological targets of small molecules. A combination of next-generation DNA sequencing with…”
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Prostaglandin E 2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells by Heffner, Garrett C, Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J, Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A, Garijo, Olivia, Torbett, Bruce E, Horton, Holly, Finer, Mitchell H, Gregory, Philip D, Veres, Gabor

“…Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34 hematopoietic stem and progenitor cells (HSPCs)…”
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Development of a fast and accurate method of 13C NMR chemical shift prediction by Blinov, Kirill A., Smurnyy, Yegor D., Churanova, Tatiana S., Elyashberg, Mikhail E., Williams, Antony J.

“…In this article we describe a fast and accurate method of 13C NMR chemical shift prediction. The high speed of chemical shift calculation described is achieved…”
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Knockout of CBLB Greatly Enhances Anti-Tumor Activity of CAR T Cells by Hooper, Kathryn, Havens, Kyle, Krostag, Anne-Rachel, Magee, Michael S, Martin, Unja, Gupta, Ankit, Smurnyy, Yegor, Pechilis, Lisa, Rode, Amanda, Chavkin, Andrew, Grande, Shannon, Morgan, Richard A., Jarjour, Jordan, Astrakhan, Alexander

“…Chimeric antigen receptor (CAR) T cell therapies continue to show excellent outcomes in hematological cancers. Achieving success in additional tumor…”
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Empirical and DFT GIAO quantum-mechanical methods of (13)C chemical shifts prediction: competitors or collaborators? by Elyashberg, Mikhail, Blinov, Kirill, Smurnyy, Yegor, Churanova, Tatiana, Williams, Antony

“…The accuracy of (13)C chemical shift prediction by both DFT GIAO quantum-mechanical (QM) and empirical methods was compared using 205 structures for which…”
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Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis by Eggert, Ulrike S, Castoreno, Adam B, Smurnyy, Yegor, Torres, Angelica D, Vokes, Martha S, Jones, Thouis R, Carpenter, Anne E

“…A new pathway screen for small molecules that suppress or enhance an RNAi phenotype in Drosophila cells was used to identify a collection of compounds that…”
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229. PGE2 Increases Lentiviral Vector Transduction Efficiency of Human HSC by Heffner, Garrett, Bonner, Melissa, Campbell, Dakota, Christiansen, Lauryn, Pierciey, F. John, Zhang, Wen, Lewis, Gretchen, Smurnyy, Yegor, Hamel, Amanda, Shah, Seema, Horton, Holly, Ryu, Byoung, Goss, Kendrick, Negre, Olivier, Veres, Gabor, Horvath, Christopher, Finer, Mitchell, Gregory, Philip

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Binucleine 2, an Isoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis by Smurnyy, Yegor, Toms, Angela V, Hickson, Gilles R, Eck, Michael J, Eggert, Ulrike S

“…Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor…”
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Empirical and DFT GIAO quantum‐mechanical methods of 13 C chemical shifts prediction: competitors or collaborators? by Elyashberg, Mikhail, Blinov, Kirill, Smurnyy, Yegor, Churanova, Tatiana, Williams, Antony

“…Abstract The accuracy of 13 C chemical shift prediction by both DFT GIAO quantum‐mechanical (QM) and empirical methods was compared using 205 structures for…”
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