Search Results - "Smrcina, Martin"

Non-Symmetrically Substituted 1,1‘-Binaphthyls in Enantioselective Catalysis by Kocovsky, Pavel, Vyskocil, Stepan, Smrcina, Martin

“…Axial chirality was predicted by van't Hoff in his historical paper, which laid the foundations of stereochemistry. BINOL (1), one of the best known…”
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Synthesis of enantiomerically pure binaphthyl derivatives. Mechanism of the enantioselective, oxidative coupling of naphthols and designing a catalytic cycle by Smrcina, Martin, Polakova, Jana, Vyskocil, Stepan, Kocovsky, Pavel

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Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis by Houštecká, Radka, Hadzima, Martin, Fanfrlík, Jindřich, Brynda, Jiří, Pallová, Lenka, Hánová, Iva, Mertlíková-Kaiserová, Helena, Lepšík, Martin, Horn, Martin, Smrčina, Martin, Majer, Pavel, Mareš, Michael

“…Human cathepsin D (CatD), a pepsin-family aspartic protease, plays an important role in tumor progression and metastasis. Here, we report the development of…”
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Synthesis of enantiomerically pure 2,2'-dihydroxy-1,1'-binaphthyl, 2,2'-diamino-1,1'-binaphthyl, and 2-amino-2'-hydroxy-1,1'-binaphthyl. Comparison of processes operating as diastereoselective crystallization and as second order asymmetric transformation by Smrcina, Martin, Lorenc, Mirolsav, Hanus, Vladimir, Sedmera, Petr, Kocovsky, Pavel

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Selective Cross-Coupling of 2-Naphthol and 2-Naphthylamine Derivatives. A Facile Synthesis of 2,2',3-Trisubstituted and 2,2',3,3'-Tetrasubstituted 1,1'-Binaphthyls by Smrcina, Martin, Vyskocil, Stepan, Maca, Bohumil, Polasek, Miroslav, Claxton, Thomas A, Abbott, Andrew P, Kocovsky, Pavel

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Derivatives of 2-Amino-2‘-diphenylphosphino-1,1‘-binaphthyl (MAP) and Their Application in Asymmetric Palladium(0)-Catalyzed Allylic Substitution by Vyskočil, Štěpán, Smrčina, Martin, Hanuš, Vladimír, Polášek, Miroslav, Kočovský, Pavel

“…(R)-(+)-2-Amino-2‘-hydroxy-1,1‘-binaphthyl (NOBIN, 5) can be readily converted into a series of novel N,N-disubstituted aminophosphines 9 and 23−25. The…”
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Preparative Separation of Mixtures by Mass Spectrometry by Mayer, Philip S, Tureček, František, Lee, Hak-No, Scheidemann, Adi A, Olney, Terry N, Schumacher, Frank, Štrop, Petr, Smrčina, Martin, Pátek, Marcel, Schirlin, Daniel

“…A specially designed mass spectrometer which allows for preparative separation of mixtures is described. This mass spectrometer allows for large ion currents,…”
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Palladium(II) Complexes of 2-Dimethylamino-2‘- diphenylphosphino-1,1‘-binaphthyl (MAP) with Unique P,Cσ-Coordination and Their Catalytic Activity in Allylic Substitution, Hartwig−Buchwald Amination, and Suzuki Coupling by Kočovský, Pavel, Vyskočil, Štěpán, Císařová, Ivana, Sejbal, Jan, Tišlerová, Iva, Smrčina, Martin, Lloyd-Jones, Guy C, Stephen, Susanna C, Butts, Craig P, Murray, Martin, Langer, Vratislav

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Synthesis of N-Alkylated and N-Arylated Derivatives of 2-Amino-2‘-hydroxy-1,1‘-binaphthyl (NOBIN) and 2,2‘-Diamino-1,1‘-binaphthyl and Their Application in the Enantioselective Addition of Diethylzinc to Aromatic Aldehydes by Vyskočil, Štěpán, Jaracz, Stanislav, Smrčina, Martin, Štícha, Martin, Hanuš, Vladimír, Polášek, Miroslav, Kočovský, Pavel

“…High-yield reductive alkylation of (R)-(+)-1 and (R)-(+)-2 has been accomplished with a series of ketones (even as bulky as 2-adamantanone) and NaBH4/H2SO4 in…”
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Selectivity of N- Versus O-Alkylation in Mitsunobu Reactions with Various Quinolinols and Isoquinolinols by E. Hartung, Ryan, C. Wall, Mark, Lebreton, Sylvain, Smrcina, Martin, Patek, Marcel

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Copper(II)-Mediated Oxidative Coupling of 2-Aminonaphthalene Homologues. Competition between the Straight Dimerization and the Formation of Carbazoles by Vyskočil, Štěpán, Smrčina, Martin, Lorenc, Miroslav, Tišlerová, Iva, Brooks, Robin D, Kulagowski, Janusz J, Langer, Vratislav, Farrugia, Louis J, Kočovský, Pavel

“…Whereas the Cu(II)-mediated oxidative coupling of 2-aminonaphthalenes 7a and 7b results in the clean formation of 1,1‘-binaphthyls 13a and 13b, respectively,…”
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The SN2 Reaction in the Solid State. An Unusual, BAl2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in SN2 Substitution by Smrčina, Martin, Vyskočil, Štěpán, Hanuš, Vladimír, Polášek, Miroslav, Langer, Vratislav, Chew, Benjamin G. M, Zax, David B, Verrier, Hugh, Harper, Kevin, Claxton, Thomas A, Kočovský, Pavel

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Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids by Smrcina, Martin, Majer, Pavel, Majerová, Eva, Guerassina, Tatiana A., Eissenstat, Michael A.

“…A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete…”
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2D and 3D Spatially Addressed Arrays for High-Throughput Automated Synthesis of Combinatorial Libraries by Patek, Marcel, Safar, Pavel, Smrčina, Martin, Wegrzyniak, Eric, Bjergarde, Kirsten, Weichsel, Aleksandra, Strop, Peter

“…One of the key elements in the drug discovery process is the use of automation to synthesize libraries of compounds for biological screening. The…”
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Solid-Phase Synthesis of Substituted Guanidines Using a Novel Acid Labile Linker by Pátek, Marcel, Smrčina, Martin, Nakanishi, Eiji, Izawa, Hiroyuki

“…A novel acid labile linker for solid-phase synthesis of substituted guanidines has been developed. Its synthetic utility is exemplified by high-yielding…”
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Synthesis of 2-amino-2′-diphenylphosphino-1,1′-binaphthyl (MAP) and its accelerating effect on the Pd(0)-catalyzed N-arylation by Vyskočil, Štěpán, Smrčina, Martin, Kočovský, Pavel

“…The title compound 3, synthesized in four steps from NOBIN ( 1), has been found to exhibit a dramatic accelerating effect on the Pd(0)-catalyzed…”
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Corner attack on cyclopropane by thallium(III) ions. A highly stereospecific cleavage and skeletal rearrangement of 3.alpha.,5-cyclo-5.alpha.-cholestan-6.alpha.-ol by Kocovsky, Pavel, Pour, Milan, Gogoll, Adolf, Hanus, Vladimir, Smrcina, Martin

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Axially chiral 1,1′-binaphthyls with non-identical groups in 2,2′-positions. Synthesis of the enantiomerically pure 2-hydroxy-2′-thiol and substituted 2-amino-2′-thiols by Smrčina, Martin, Vyskočil, Štěpán, Polívková, Jana, Poláková, Jana, Sejbal, Jan, Hanus, Vladimír, Polášek, Miroslav, Verrier, Hugh, Kočovský, Pavel

“…Enantiomerically pure hydroxy thiol (S)-(+)- 6 , amino thiol (S)-(+)- 12 , and N, N-dimethylamino thiol (S)-(−)- 16 have been synthesized from BINOL (S)-(−)- 1…”
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Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl by Smrčina, Martin, Vyskočil, Štěpán, Polívková, Jana, Poláková, Jana, Kočovský, Pavel

“…The title compound 3 has been prepared via a highly selective, Cu(II)-mediated cross-coupling of 2-aminonaphthalene 1 and 2-naphthol 2 and resolved into…”
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The S N 2 Reaction in the Solid State. An Unusual, B Al 2 Aminolysis of an Ester Group in Crystalline (±)-2-Amino-2‘-hydroxy-3‘-(methoxycarbonyl)- 1,1‘-binaphthyl Elucidated by X-ray Diffraction and Isotopic Labeling. New Experimental Evidence for Linearity in S N 2 Substitution by Smrčina, Martin, Vyskočil, Štěpán, Hanuš, Vladimír, Polášek, Miroslav, Langer, Vratislav, Chew, Benjamin G. M., Zax, David B., Verrier, Hugh, Harper, Kevin, Claxton, Thomas A., Kočovský, Pavel

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