Search Results - "Smolkin, Matthew B"

Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer by Kozyreva, Varvara K, Kiseleva, Anna A, Ice, Ryan J, Jones, Brandon C, Loskutov, Yuriy V, Matalkah, Fatimah, Smolkin, Matthew B, Marinak, Kristina, Livengood, Ryan H, Salkeni, Mohamad A, Wen, Sijin, Hazard, Hannah W, Layne, Ginger P, Walsh, Callee M, Cantrell, Pamela S, Kilby, Greg W, Mahavadi, Sricharan, Shah, Neal, Pugacheva, Elena N

“…Recent findings suggest that the inhibition of Aurora A (AURKA) kinase may offer a novel treatment strategy against metastatic cancers. In the current study,…”
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NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner by Kozyreva, Varvara K, McLaughlin, Sarah L, Livengood, Ryan H, Calkins, Robin A, Kelley, Laura C, Rajulapati, Anuradha, Ice, Ryan J, Smolkin, Matthew B, Weed, Scott A, Pugacheva, Elena N

“…The prometastatic protein NEDD9 (neural precursor cell expressed, developmentally downregulated 9) is highly expressed in many cancers and is required for…”
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Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura by Boothe, James T., Budd, G. Thomas, Smolkin, Matthew B., Ma, Patrick C.

“…Solitary fibrous tumor of the pleura is a rare and usually benign primary neoplasm arising from mesenchymal cells of the submesothelial tissue. We present here…”
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Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma by Madan, Rashna, Smolkin, Matthew B., Cocker, Rubina, Fayyad, Rana, Oktay, Maja H.

“…Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells…”
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Nuclear Aurora-A kinase-induced hypoxia signaling drives early dissemination and metastasis in breast cancer: implications for detection of metastatic tumors by Whately, Kristina M., Voronkova, Maria A., Maskey, Abha, Gandhi, Jasleen, Loskutov, Juergen, Choi, Hyeran, Yanardag, Sila, Chen, Dongquan, Wen, Sijin, Margaryan, Naira V., Smolkin, Matthew B., Purazo, Marc L., Hu, Gangqing, Pugacheva, Elena N.

“…Metastatic breast cancer causes most breast cancer-associated deaths, especially in triple negative breast cancers (TNBC). The metastatic drivers of TNBCs are…”
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Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis by Addison, Joseph B, Voronkova, Maria A, Fugett, James H, Lin, Chen-Chung, Linville, Nathaniel C, Trinh, Brandon, Livengood, Ryan H, Smolkin, Matthew B, Schaller, Michael D, Ruppert, J Michael, Pugacheva, Elena N, Creighton, Chad J, Ivanov, Alexey V

“…Several master transcription factors (TF) can activate the epithelial-to-mesenchymal transition (EMT). However, their individual and combinatorial…”
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Hereditary Trichilemmal Cysts are Caused by Two Hits to the Same Copy of the Phospholipase C Delta 1 Gene (PLCD1) by Kolodney, Michael S., Coman, Garrett C., Smolkin, Matthew B., Hagen, Rachael, Katzman, Jacob A., Katzman, Steven N, Holliday, Alex C., Kolodney, Joanna A.

“…The autosomal dominant presentation of trichilemmal cysts is one of the most common single gene familial diseases in humans. However, the genetic basis for the…”
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Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior by Jones, Brandon C, Kelley, Laura C, Loskutov, Yuriy V, Marinak, Kristina M, Kozyreva, Varvara K, Smolkin, Matthew B, Pugacheva, Elena N

“…Commonly upregulated in human cancers, the scaffolding protein NEDD9/HEF1 is a known regulator of mesenchymal migration and cancer cell plasticity. However,…”
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The Stem Cell Phenotype of Aggressive Breast Cancer Cells by Margaryan, Naira V, Hazard-Jenkins, Hannah, Salkeni, Mohamad A, Smolkin, Matthew B, Coad, James A, Wen, Sijin, Seftor, Elisabeth A, Seftor, Richard E B, Hendrix, Mary J C

“…Aggressive cancer cells are characterized by their capacity to proliferate indefinitely and to propagate a heterogeneous tumor comprised of subpopulations with…”
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Trends in Lung Cancer Molecular Testing by Smolkin, Matthew B, Almubarak, Mohammed, Perrotta, Peter L

“…Molecular testing of non-small cell lung carcinomas (NSCLCC) with adenocarcinoma features has become commonplace with the development and use of targeted…”
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Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma : Report of a case of a challenging cytologic diagnosis by OKTAY, Maja H, SMOLKIN, Matthew B, WILLIAMS, Mark, CAJIGAS, Antonio

“…The probability of anaplastic transformation in a differentiated thyroid carcinoma (DTC) is <2%. Admixture of DTC and undifferentiated carcinoma can…”
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NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer by Loskutov, Y V, Kozyulina, P Y, Kozyreva, V K, Ice, R J, Jones, B C, Roston, T J, Smolkin, M B, Ivanov, A V, Wysolmerski, R B, Pugacheva, E N

“…NEDD9 is an established marker of invasive and metastatic cancers. NEDD9 downregulation has been shown to dramatically reduce cell invasion and metastasis in…”
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Metastatic Anaplastic Carcinoma of the Thyroid Mimicking Squamous Cell Carcinoma by Oktay, Maja H., Smolkin, Matthew B., Williams, Mark, Cajigas, Antonio

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Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura by Boothe, James T, Budd, G Thomas, Smolkin, Matthew B, Ma, Patrick C

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