Search Results - "Smolka, Marcus"

Checkpoint Responses to DNA Double-Strand Breaks by Waterman, David P, Haber, James E, Smolka, Marcus B

“…Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell…”
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ATR takes a crack at the nuclear envelope by Smolka, Marcus B, Lammerding, Jan

“…In this issue, Joo et al. and Kovacs et al. report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing…”
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TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor by MacGurn, Jason A., Hsu, Pi-Chiang, Smolka, Marcus B., Emr, Scott D.

“…The TORC1 kinase signaling complex is a key determinant of cell growth that senses nutritional status and responds by coordinating diverse cellular processes…”
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Progranulin deficiency leads to reduced glucocerebrosidase activity by Zhou, Xiaolai, Paushter, Daniel H, Pagan, Mitchell D, Kim, Dongsung, Nunez Santos, Mariela, Lieberman, Raquel L, Overkleeft, Herman S, Sun, Ying, Smolka, Marcus B, Hu, Fenghua

“…Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in…”
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DNA-PKcs promotes fork reversal and chemoresistance by Dibitetto, Diego, Marshall, Shannon, Sanchi, Andrea, Liptay, Martin, Badar, Jumana, Lopes, Massimo, Rottenberg, Sven, Smolka, Marcus B.

“…The DNA-PKcs kinase mediates the repair of DNA double-strand breaks via classical non-homologous end joining (NHEJ). DNA-PKcs is also recruited to active…”
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In-depth and 3-dimensional exploration of the budding yeast phosphoproteome by Lanz, Michael C, Yugandhar, Kumar, Gupta, Shagun, Sanford, Ethan J, Faça, Vitor M, Vega, Stephanie, Joiner, Aaron M N, Fromme, J Christopher, Yu, Haiyuan, Smolka, Marcus B

“…Phosphorylation is one of the most dynamic and widespread post-translational modifications regulating virtually every aspect of eukaryotic cell biology. Here,…”
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ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells by Kim, Dongsung, Liu, Yi, Oberly, Susannah, Freire, Raimundo, Smolka, Marcus B

“…Abstract The ATR kinase is crucial for genome maintenance, but the mechanisms by which ATR controls the DNA repair machinery are not fully understood. Here, we…”
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Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin by Zhou, Xiaolai, Sun, Lirong, Bastos de Oliveira, Francisco, Qi, Xiaoyang, Brown, William J, Smolka, Marcus B, Sun, Ying, Hu, Fenghua

“…Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal…”
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Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation by Bai, Gongshi, Smolka, Marcus B, Schimenti, John C

“…Circumstances that compromise efficient DNA replication, such as disruptions to replication fork progression, cause a state known as DNA replication stress…”
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Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements by Xie, Bokun, Sanford, Ethan James, Hung, Shih-Hsun, Wagner, Mateusz, Heyer, Wolf-Dietrich, Smolka, Marcus B

“…The Mec1/ATR kinase is crucial for genome stability, yet the mechanism by which it prevents gross chromosomal rearrangements (GCRs) remains unknown. Here we…”
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The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice by Horan, Tegan S, Ascenção, Carolline F R, Mellor, Christopher, Wang, Meng, Smolka, Marcus B, Cohen, Paula E

“…Meiotic recombination between homologous chromosomes is initiated by the formation of hundreds of programmed double-strand breaks (DSBs). Approximately 10% of…”
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DNA damage kinase signaling: checkpoint and repair at 30 years by Lanz, Michael Charles, Dibitetto, Diego, Smolka, Marcus Bustamante

“…From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair pathways. In eukaryotes, kinases play a central role in coordinating the DNA…”
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Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells by Viswanatha, Raghuvir, Ohouo, Patrice Y, Smolka, Marcus B, Bretscher, Anthony

“…In this paper, we describe how a dynamic regulatory process is necessary to restrict microvilli to the apical aspect of polarized epithelial cells. We found…”
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Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases by Smolka, Marcus B, Albuquerque, Claudio P, Chen, Sheng-hong, Zhou, Huilin

“…Understanding the role of DNA damage checkpoint kinases in the cellular response to genotoxic stress requires the knowledge of their substrates. Here, we…”
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The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway by Sullivan, Peter M, Zhou, Xiaolai, Robins, Adam M, Paushter, Daniel H, Kim, Dongsung, Smolka, Marcus B, Hu, Fenghua

“…Hexanucleotide repeat expansion in the C9orf72 gene is a leading cause of frontotemporal lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS)…”
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Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain–containing Legionella effectors by Wan, Min, Sulpizio, Alan G., Akturk, Anil, Beck, Wendy H. J., Lanz, Michael, Faça, Vitor M., Smolka, Marcus B., Vogel, Joseph P., Mao, Yuxin

“…Posttranslational protein modification by ubiquitin (Ub) is a central eukaryotic mechanism that regulates a plethora of physiological processes. Recent studies…”
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A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis by Albuquerque, Claudio P., Smolka, Marcus B., Payne, Samuel H., Bafna, Vineet, Eng, Jimmy, Zhou, Huilin

“…Protein phosphorylation is a post-translational modification widely used to regulate cellular responses. Recent studies showed that global phosphorylation…”
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Structural basis of TRAPPIII‐mediated Rab1 activation by Joiner, Aaron MN, Phillips, Ben P, Yugandhar, Kumar, Sanford, Ethan J, Smolka, Marcus B, Yu, Haiyuan, Miller, Elizabeth A, Fromme, J Christopher

“…The GTPase Rab1 is a master regulator of the early secretory pathway and is critical for autophagy. Rab1 activation is controlled by its guanine nucleotide…”
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A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization by Cao, Xiaofu, Huang, Shiying, Wagner, Mateusz M., Cho, Yuan-Ting, Chiu, Din-Chi, Wartchow, Krista M., Lazarian, Artur, McIntire, Laura Beth, Smolka, Marcus B., Baskin, Jeremy M.

“…Tools for acute manipulation of protein localization enable elucidation of spatiotemporally defined functions, but their reliance on exogenous triggers can…”
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In-depth mapping of DNA-PKcs signaling uncovers noncanonical features of its kinase specificity by Marshall, Shannon, Navarro, Marcos V.A.S., Ascenҫão, Carolline F.R., Dibitetto, Diego, Smolka, Marcus B.

“…DNA-PKcs is a DNA damage sensor kinase with established roles in DNA double-strand break repair via nonhomologous end joining. Recent studies have revealed…”
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