Search Results - "Smoligovets, Alexander A"

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells by O'Donoghue, Geoff P, Pielak, Rafal M, Smoligovets, Alexander A, Lin, Jenny J, Groves, Jay T

“…T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions…”
Get full text

Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation by Yu, Yan, Fay, Nicole C, Smoligovets, Alexander A, Wu, Hung-Jen, Groves, Jay T

“…Activation of T cell receptor (TCR) by antigens occurs in concert with an elaborate multi-scale spatial reorganization of proteins at the immunological…”
Get full text

Ratiometric Imaging of the T-Cell Actin Cytoskeleton Reveals the Nature of Receptor-Induced Cytoskeletal Enrichment by Smoligovets, Alexander A., Smith, Adam W., Groves, Jay T.

“…The T-cell actin cytoskeleton mediates adaptive immune system responses to peptide antigens by physically directing the motion and clustering of T-cell…”
Get full text

Patterned Two-Photon Photoactivation Illuminates Spatial Reorganization in Live Cells by Smith, Adam W, Smoligovets, Alexander A, Groves, Jay T

“…Photoactivatable fluorescent proteins offer the possibility to optically tag and track the location of molecules in their bright state with high spatial and…”
Get full text

Modulation of T cell signaling by the actin cytoskeleton by Yu, Yan, Smoligovets, Alexander A, Groves, Jay T

“…The actin cytoskeleton provides a dynamic framework to support membrane organization and cellular signaling events. The importance of actin in T cell function…”
Get full text

Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells by Smoligovets, Alexander A, Smith, Adam W, Wu, Hung-Jen, Petit, Rebecca S, Groves, Jay T

“…T cell triggering through T-cell antigen receptors (TCRs) results in spatial assembly of the receptors on multiple length scales. This assembly is mediated by…”
Get full text

Non-Muscle Myosin IIA at the Immunological Synapse: Integration of Mechanical Regulation with T Cell Signaling by Yu, Yan, Fay, Nicole C., Smoligovets, Alexander A., Wu, Hung-Jen, Groves, Jay T.

Get full text