Search Results - "Smolen, JE"

Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis by Serhan, C N, Radin, A, Smolen, J E, Korchak, H, Samuelsson, B, Weissmann, G

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L-Selectin Signaling of Neutrophil Adhesion and Degranulation Involves p38 Mitogen-activated Protein Kinase by Smolen, James E., Petersen, Thomas K., Koch, Cody, O'Keefe, Stephen J., Hanlon, William A., Seo, Scott, Pearson, David, Fossett, Milligan C., Simon, Scott I.

“…The adhesion molecules known as selectins mediate the capture of neutrophils from the bloodstream. We have previously reported that ligation and cross-linking…”
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Liposomes in the study of membrane fusion in neutrophils by Smolen, James E

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Identification of glyceraldehyde-3-phosphate dehydrogenase as a Ca2+-dependent fusogen in human neutrophil cytosol by Hessler, Ronald J., Blackwood, R. Alexander, Brock, Thomas G., Francis, Joseph W., Harsh, Donna M., Smolen, James E.

“…The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the…”
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Human neutrophil annexin I promotes granule aggregation and modulates Ca2+ -dependent membrane fusion by FRANCIS, J. W, BALAZOVICH, K. J, SMOLEN, J. E, MARGOLIS, D. I, BOXER, L. A

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Phospholipase D activity facilitates Ca2+-induced aggregation and fusion of complex liposomes by Blackwood, R A, Smolen, J E, Transue, A, Hessler, R J, Harsh, D M, Brower, R C, French, S

“…Phospholipase D (PLD) activation in stimulated neutrophils results in the conversion of membrane phosphatidylcholine (PC) to phosphatidic acid (PA). This…”
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Identification of glyceraldehyde-3-phosphate dehydrogenase as a Ca super(2+)-dependent fusogen in human neutrophil cytosol by Hessler, R J, Blackwood, R A, Brock, T G, Francis, J W, Harsh, D M, Smolen, JE

“…The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the…”
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Identification and cloning of the SNARE proteins VAMP-2 and syntaxin-4 from HL-60 cells and human neutrophils by Smolen, J E, Hessler, R J, Nauseef, W M, Goedken, M, Joe, Y

“…Degranulation and membrane fusion by neutrophils are essential to host defense. We sought homologues of neuron-specific fusion proteins in human neutrophils…”
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Release of inflammatory mediators from stimulated neutrophils by Weissmann, G, Smolen, J E, Korchak, H M

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Guanine nucleotides reduce the calcium requirement for granule enzyme secretion from permeabilized human neutrophils by Smolen, JE

“…Since guanine nucleotides have been shown to be intimately involved in stimulus-response coupling mechanism in neutrophils and other cell types, the authors…”
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The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils by Smolen, J E, Korchak, H M, Weissmann, G

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The fluorescence response of chlortetracycline-loaded human neutrophils is modulated by prostaglandin E sub(1), but not by cyclic nucleotides by Smolen, JE

“…Human neutrophils preloaded with chlortetracycline, commonly used as a probe of membrane-bound calcium, demonstrate a prompt decrease in fluorescence when…”
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PLA sub(2) promotes fusion between PMN-specific granules and complex liposomes by Blackwood, R A, Transue, A T, Harsh, D M, Brower, R C, Zacharek, S J, Smolen, JE, Hessler, R J

“…Neutrophil stimulation results in the activation of a variety of phospholipases, including phospholipase A sub(2) (PLA sub(2)), which releases arachidonic acid…”
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Neutrophil granule constituents and their release in health and disease by Boxer, L A, Smolen, J E

“…In this review of secretion by neutrophils, we have given a detailed description of the characteristics of the exocytotic responses of these cells to a variety…”
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Development of an aqueous-space mixing assay for fusion of granules and plasma membranes from human neutrophils by Blackwood, R A, Smolen, J E, Hessler, R J, Harsh, D M, Transue, A

“…Several models have been developed to study neutrophil degranulation. At the most basic level, phospholipid vesicles have been used to investigate the lipid…”
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Human neutrophils contain a protein kinase C-like enzyme that utilizes guanosine triphosphate as a phosphate donor. Cofactor requirements, kinetics, and endogenous acceptor proteins by Stoehr, SJ, Smolen, JE

“…Investigations of protein kinase C (PKC) activity have focussed on protein phosphorylation using adenosine triphosphate (ATP), not guanosine triphosphate…”
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Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor by Sklar, L A, Bokoch, G M, Button, D, Smolen, J E

“…Intact neutrophils exhibit interconverting active and inactive receptor states with half-times for dissociation of 10 s and 2 min, respectively. We examined…”
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Exposure of Human Neutrophils to Exogenous Nucleotides Causes Elevation in Intracellular Calcium, Transmembrane Calcium Fluxes, and an Alteration of a Cytosolic Factor Resulting in Enhanced Superoxide Production in Response to FMLP and Arachidonic Acid by Axtell, Richard A., Sandborg, Rebecca R., Smolen, James E., Ward, Peter A., Boxer, Laurence A.

“…Exposure of human neutrophils to micromolar concentrations of both hydrolyzable and nonhydrolyzable purine nucleotides caused the generation of transient rises…”
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Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation by Smolen, J E, Korchak, H M, Weissmann, G

“…Levels of cyclic AMP (cAMP) (but not cyclic GMP) in suspensions of human polymorphonuclear leukocytes (PMN) increased promptly after exposure of the cells to…”
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Modeling degranulation with liposomes : effect of lipid composition on membrane fusion by BROCK, T. G, NAGAPRAKASH, K, MARGOLIS, D. I, SMOLEN, J. E

“…Degranulation involves the regulated fusion of granule membrane with plasma membrane. To study the role of lipid composition in degranulation, large…”
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