Search Results - "Smoleński, Ryszard T"

Management of neurological symptoms in Lesch-Nyhan disease: A systematic review by Krajewski, Oliwier, Opiełka, Mikołaj, Urbanowicz, Krzysztof, Chojnowski, Karol, Kochany, Paweł, Pawłowski, Kacper, Tomaszewska, Jagoda, Peters, Godefridus J., Smoleński, Ryszard T., Bełdzińska, Maria Mazurkiewicz

“…Lesch-Nyhan Disease (LND) is an X-linked recessive genetic disorder arising from hypoxanthine phosphoribosyltransferase 1 gene mutations, leading to a complete…”
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Novel mass spectrometry-based assay for thymidylate synthase activity by Urbanowicz, Krzysztof, Turyn, Jacek, Smoleński, Ryszard T, Peters, Godefridus J

“…Thymidylate synthase (TS) is an enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), with the…”
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Blocking cholesterol formation and turnover improves cellular and mitochondria function in murine heart microvascular endothelial cells and cardiomyocytes by Braczko, Alicja, Harasim, Gabriela, Kawecka, Ada, Walczak, Iga, Kapusta, Małgorzata, Narajczyk, Magdalena, Stawarska, Klaudia, Smoleński, Ryszard T., Kutryb-Zając, Barbara

“…Background: Statins and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are cornerstones of therapy to prevent cardiovascular disease, acting…”
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Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington’s disease by Pierzynowska, Karolina, Podlacha, Magdalena, Łuszczek, Dorota, Rintz, Estera, Gaffke, Lidia, Szczudło, Zuzanna, Tomczyk, Marta, Smoleński, Ryszard T., Węgrzyn, Grzegorz

“…•Pelage is changed in the R61/ and R6/2 mouse models of Huntington’s disease (HD)•Hair dysmorphology, assessed by scanning electron microscopy, is evident in…”
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Effects of lactate dehydrogenase A and GLUT1 inhibition on human endothelial cell migration in relation to their intracellular nucleotide pool by Harasim, Gabriela, Frańczak, Marika A, Minutolo, Filippo, Granchi, Carlotta, Giovannetti, Elisa, Słomińska, Ewa M, Smoleński, Ryszard T, Peters, Godefridus J

“…The expression of both lactate dehydrogenase A (LDH-A) and glucose transporter type 1 (GLUT1) is high in pancreatic, thoracic and many other types of cancer…”
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Evaluation of the combination of gemcitabine, carboplatin, and lactate dehydrogenase A inhibitor on malignant mesothelioma by Frańczak, Marika A, Borea, Federica, Smoleński, Ryszard T, Granchi, Carlotta, Minutolo, Filippo, Giovannetti, Elisa, Peters, Godefridus J

“…Lactate dehydrogenase A (LDH-A) catalyzes the last step of glycolysis: supplying cells rapidly but inefficiently with ATP. Many tumors, including malignant…”
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Evaluation of N4-hydroxycytidine incorporation into nucleic acids of SARS-CoV-2-infected host cells by direct measurement with liquid chromatography-mass spectrometry by Urbanowicz, Krzysztof, Opielka, Mikolaj, Stegmann, Kim M, Dickmanns, Antje, Dobbelstein, Matthias, Peters, Godefridus J, Smoleński, Ryszard T

“…Molnupiravir, an orally administered prodrug of β-d-N4-hydroxycytidine (NHC), is incorporated into newly synthesized RNA by viral RNA-dependent RNA polymerase…”
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Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia by Czuba-Pakuła, Ewelina, Pelikant-Małecka, Iwona, Lietzau, Grażyna, Wójcik, Sławomir, Smoleński, Ryszard T., Kowiański, Przemysław

“…Hypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the context of…”
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Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID by Romanowska-Kocejko, Marzena, Jędrzejewska, Agata, Braczko, Alicja, Stawarska, Klaudia, Król, Oliwia, Frańczak, Marika, Harasim, Gabriela, Smoleński, Ryszard T, Hellmann, Marcin, Kutryb-Zając, Barbara

“…Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape…”
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Metabolism of 4-pyridone-3-carboxamide-1β-d-ribonucleoside (4PYR) in primary murine brain microvascular endothelial cells (mBMECs) by Pelikant-Małecka, Iwona, Smoleński, Ryszard T., Słomińska, Ewa M.

“…4-pyridone-3-carboxamide-1β-D-ribonucleoside (4PYR) is a derivative of nicotinamide found physiologically in human body fluids that can be metabolized to…”
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Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq44 mice by Czarnowska, Elżbieta, Bierła, Joanna B, Toczek, Marta, Tyrankiewicz, Urszula, Pająk, Beata, Domal-Kwiatkowska, Dorota, Ratajska, Anna, Smoleński, Ryszard T, Mende, Ulrike, Chłopicki, Stefan

“…The timing and consequences of alternations in substrate utilization in heart failure (HF) and their relationship with structural changes remain unclear. This…”
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4-Pyridone-3-Carboxamide-1β-D-Ribonucleoside Metabolism in Endothelial Cells and Its Impact on Cellular Energetic Balance by Pelikant-Małecka, Iwona, Sielicka, Alicja, Kaniewska, Ewa, Smoleński, Ryszard T., Słomińska, Ewa M.

“…4-Pyridone-3-carboxamide-1β-D-ribonucleoside (4PYR) is a naturally occurring compound related to nicotinamide that could be metabolized to mono-, di-, and…”
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1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages by Biedroń, Rafał, Ciszek, Marta, Tokarczyk, Marianna, Bobek, Małgorzata, Kurnyta, Maria, Słominska, Ewa M, Smoleński, Ryszard T, Marcinkiewicz, Janusz

“…Introduction: 1-Methylnicotinamide (MNA), a major metabolite of nicotinamide (NA), is known to exert anti-inflammatory effects in vivo. Treatment of…”
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Increased protein degradation as well as lactate and malate dehydrogenase activity in sterile and infected walled-off pancreatic necrosis by Rojek, Łukasz, Smoczyński, Marian, Stojek, Magdalena, Śledziński, Tomasz, Smoleński, Ryszard T, Adrych, Krystian

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Extracellular Adenine Nucleotide Catabolism in Heart Valves by Toczek, Marta, Kutryb-Zając, Barbara, Kapczyńska, Małgorzata, Lipiński, Marcin, Słomińska, Ewa M., Smoleński, Ryszard T.

“…Enzymes of extracellular nucleotide catabolism, such as ecto-nucleoside triphosphate diphosphohydrolase (eNTPD), ecto-5′-nucleotidase (e5NT) and ecto-adenosine…”
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Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases by Kutryb-Zajac, Barbara, Mierzejewska, Paulina, Slominska, Ewa M, Smolenski, Ryszard T

“…Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2'deoxyadenosine to 2'deoxyinosine. ADA is…”
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Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside by Mateuszuk, Łukasz, Campagna, Roberto, Kutryb-Zając, Barbara, Kuś, Kamil, Słominska, Ewa M., Smolenski, Ryszard T., Chlopicki, Stefan

“…[Display omitted] Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are effective substrates for NAD synthesis, which may act as vasoprotective…”
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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model by Konieczna-Wolska, Klaudia, Caratis, Fionä, Opiełka, Mikołaj, Biernacki, Karol, Urbanowicz, Krzysztof, Klimaszewska, Joanna, Pobiarzyn, Piotr, Krajewski, Oliwier, Demkowicz, Sebastian, Smoleński, Ryszard T., Karaszewski, Bartosz, Seuwen, Klaus, Rutkowska, Aleksandra

“…Research indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of…”
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Vitamin B12 Metabolism: A Network of Multi-Protein Mediated Processes by Mucha, Patryk, Kus, Filip, Cysewski, Dominik, Smolenski, Ryszard T., Tomczyk, Marta

“…The water-soluble vitamin, vitamin B12, also known as cobalamin, plays a crucial role in cellular metabolism, particularly in DNA synthesis, methylation, and…”
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Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer by Kutryb-Zajac, Barbara, Harasim, Gabriela, Jedrzejewska, Agata, Krol, Oliwia, Braczko, Alicja, Jablonska, Patrycja, Mierzejewska, Paulina, Zielinski, Jacek, Slominska, Ewa M, Smolenski, Ryszard T

“…Several lines of evidence suggest that altered adenosine deaminase (ADA) activity, especially its ADA2 iso-enzyme, is associated with malignant breast cancer…”
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