Search Results - "Smits, Shannon M. A."

Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis by Rodenburg, Lisa W., Metzemaekers, Mieke, van der Windt, Isabelle S., Smits, Shannon M. A., den Hertog-Oosterhoff, Loes A., Kruisselbrink, Evelien, Brunsveld, Jesse E., Michel, Sabine, de Winter-de Groot, Karin M., van der Ent, Cornelis K., Stadhouders, Ralph, Beekman, Jeffrey M., Amatngalim, Gimano D.

“…The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies…”
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Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids by Rodenburg, Lisa W, Delpiano, Livia, Railean, Violeta, Centeio, Raquel, Pinto, Madalena C, Smits, Shannon M A, van der Windt, Isabelle S, van Hugten, Casper F J, van Beuningen, Sam F B, Rodenburg, Remco N P, van der Ent, Cornelis K, Amaral, Margarida D, Kunzelmann, Karl, Gray, Michael A, Beekman, Jeffrey M, Amatngalim, Gimano D

“…Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator…”
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Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay by Rodenburg, Lisa W., van der Windt, Isabelle S., Dreyer, Henriette H.M., Smits, Shannon M.A., den Hertog - Oosterhoff, Loes A., Aarts, Ellen M., Beekman, Jeffrey M., Amatngalim, Gimano D.

“…We present a protocol to generate organoids from air-liquid-interface (ALI)-differentiated nasal epithelia. We detail their application as cystic fibrosis (CF)…”
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